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LOXO-195

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Company Name: Changzhou Fulangke Chemical Technology Co., Ltd.  Gold
Tel: 13776872728
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Company Name: TargetMol Chemicals Inc.  Gold
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Company Name: Dalian Meilun Biotech Co., Ltd.  
Tel: 0411-62910999 13889544652
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Company Name: Shanghai Topbiochem Technology Co., Ltd  
Tel: 021-58170097
Email: info@topbiochem.com

LOXO-195 manufacturers

  • LOXO-195 USP/EP/BP
  • LOXO-195 USP/EP/BP pictures
  • $1.10
  • 2026-08-20
  • CAS:2097002-61-2
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons min
  • Selitrectinib
  • Selitrectinib pictures
  • $34.00
  • 2026-07-14
  • CAS:2097002-61-2
  • Purity: 99.97%
  • Supply Ability: 10g
  • LOXO-195
  • LOXO-195 pictures
  • 2026-07-06
  • CAS:2097002-61-2
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1000kg
LOXO-195 Basic information
Product Name:LOXO-195
Synonyms:(3aR,10R)-5-Fluoro-1,2,3,3a,8,9,10,11-octahydro-10-methyl-12H-15,17-ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-12-one;selitrectinib（LOXO-195）;CS-2800;LOXO-195;LOXO195;LOXO 195(Selitrectinib);Selitrectinib (Synonyms: LOXO-195);12H-15,17-Ethenopyrazolo[3,4-d]pyrido[2,3-k]pyrrolo[2,1-m][1,3,7]triazacyclotridecin-12-one, 5-fluoro-1,2,3,3a,8,9,10,11-octahydro-10-methyl-, (3aR,10R)-;LOXO-195 USP/EP/BP
CAS:2097002-61-2
MF:C20H21FN6O
MW:380.42
EINECS:
Product Categories:
Mol File:2097002-61-2.mol
LOXO-195 Structure
LOXO-195 Chemical Properties
density 1.51±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:62.5(Max Conc. mg/mL);164.29(Max Conc. mM)
form A crystalline solid
pka11.44±0.40(Predicted)
color White to yellow
InChIInChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17-/m1/s1
InChIKeyOEBIHOVSAMBXIB-SJKOYZFVSA-N
SMILESN12CCC[C@]1([H])C1=CC(F)=CN=C1CC[C@@H](C)NC(=O)C1C=NN3C=CC2=NC=13
Safety Information
HS Code 2933998090
MSDS Information
LOXO-195 Usage And Synthesis
UsesLOXO-195 (Selitrectinib) is a second-generation TRK kinase inhibitor that targets TRK fusion-positive tumors and is used to treat tumor patients who are resistant to first-generation TRK inhibitors.
in vivo

Stably transfected NIH-3T3 ΔTRKA and ΔTRKA-G595R cells are implanted subcutaneously into the flanks of nude mice. Both larotrectinib and Selitrectinib (LOXO-195) are effective at reducing phosphorylated TRKA in tumors driven by ΔTRKA. In contrast, only Selitrectinib (LOXO-195) strongly suppresses phospho-TRKA in ΔTRKA-G595R cells in a dose-dependent manner. Selitrectinib (LOXO-195) also causes inhibition of tumor growth relative to vehicle at all doses in four TRKA-dependent tumor models (ΔTRKA, ΔTRKA-G595R, ΔTRKAG667C, and TPM3-NTRK1 fusion-positive KM12 colorectal cancer cells. Larotrectinib inhibits KM12 and NIH 3T3-ΔTRKA tumors to a similar degree. Group mean body weight loss does not exceed 5% for any agent. Selitrectinib (LOXO-195) displays high selectivity for the TRK proteins[1]

IC 50TrkA: 0.6 nM (IC50); TrkC: <2.5 nM (IC50)
LOXO-195 Preparation Products And Raw materials
Tag:LOXO-195(2097002-61-2) Related Product Information
Selpercatinib Repotrectinib Entrectinib LOXO-195 Buparlisib Hydrochloride Crizotinib Lorlatinib