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Azido-PEG3-Val-Cit-PAB-PNP

Azido-PEG3-Val-Cit-PAB-PNP Structure
Azido-PEG3-Val-Cit-PAB-PNP structure
CAS No.
2055047-18-0
Chemical Name:
Azido-PEG3-Val-Cit-PAB-PNP
Synonyms
4-((14S,17S)-1-Azido-14-isopropyl-12,15-dioxo-17-(3-ureidopropyl)-3,6,9-trioxa-13,16-diazaoctadecan-18-amido)benzyl (4-nitrophenyl) carbonate;Azido-PEG3-Val-Cit-PAB-PNP
CBNumber:
CB83373570
Molecular Formula:
C34H47N9O12
Molecular Weight:
773.8
MDL Number:
MFCD30527416
MOL File:
2055047-18-0.mol
MSDS File:
SDS
Last updated:2026-07-16 07:06:08
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Azido-PEG3-Val-Cit-PAB-PNP Properties

solubility Soluble in DMSO, DMF
form Solid
color White to light yellow
InChIKey HLBCDJANEWKOSX-XIKWSGLJNA-N
SMILES [C@@H](CCCNC(=O)N)(NC(=O)[C@H](C(C)C)NC(=O)CCOCCOCCOCCN=[N+]=[N-])C(=O)NC1C=CC(COC(=O)OC2C=CC(N(=O)=O)=CC=2)=CC=1 |&1:0,11,r|

Azido-PEG3-Val-Cit-PAB-PNP price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0114400 Azido-PEG3-Val-Cit-PAB-PNP ≥98% 2055047-18-0 50mg $539 2026-06-04 Buy
ChemScene CS-0114400 Azido-PEG3-Val-Cit-PAB-PNP ≥98% 2055047-18-0 100mg $950 2026-06-04 Buy
BroadPharm bp-23368 Azido-PEG3-Val-Cit-PAB-PNP 98% 2055047-18-0 50MG $750 2026-05-24 Buy
BroadPharm bp-23368 Azido-PEG3-Val-Cit-PAB-PNP 98% 2055047-18-0 100MG $1200 2026-05-24 Buy
BroadPharm bp-23368 Azido-PEG3-Val-Cit-PAB-PNP 98% 2055047-18-0 250MG $2300 2026-05-24 Buy
Product number Packaging Price Buy
CS-0114400 50mg $539 Buy
CS-0114400 100mg $950 Buy
bp-23368 50MG $750 Buy
bp-23368 100MG $1200 Buy
bp-23368 250MG $2300 Buy

Azido-PEG3-Val-Cit-PAB-PNP Chemical Properties, Uses, Production

Description

Azido-PEG3-Val-Cit-PAB-PNP is a cleavable peptide ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. PNP groupg is a good leaving group when treating with aminebearing payload. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility.

Uses

Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs; Protease Cleavable Linker; Cleavable Linker

References

[1] Dan N, et al. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel). 2018 Apr 9;11(2). pii: E32. DOI:10.3390/ph11020032
[2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

Azido-PEG3-Val-Cit-PAB-PNP Preparation Products And Raw materials

Raw materials

Preparation Products

Azido-PEG3-Val-Cit-PAB-PNP Suppliers

Global Suppliers ( 34)
Supplier Tel Email Country ProdList Advantage
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 0431-80534353 19917294565 et@chemextension.com China 3904 55
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4229 58
Abydos Scientific 18936879710 18851749494 sales@abydoscientific.com China 1000 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Hangzhou Huarong Pharm Co., Ltd. 571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3147 58
Shaanxi Xinyan Bomei Biotechnology Co., Ltd. 13892832556 2440688701@qq.com China 1978 58
Nanchang Tianzhen Biotechnology Co., Ltd 13758194781 13173652190 522013271@qq.com China 2447 58
Shanghai Haohong Pharmaceutical Co., Ltd. 400-8210725 4008210725 malulu@leyan.com China 39999 58
Supplier Advantage
Bide Pharmatech Ltd. 60
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 55
Xi'an Confluore Biological Technology Co., Ltd. 58
Abydos Scientific 58
Shanghai Hongye Biotechnology Co. Ltd 58
TargetMol Chemicals Inc. 58
Hangzhou Huarong Pharm Co., Ltd. 58
Shaanxi Xinyan Bomei Biotechnology Co., Ltd. 58
Nanchang Tianzhen Biotechnology Co., Ltd 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58

View Latest Price from Azido-PEG3-Val-Cit-PAB-PNP manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Azido-PEG3-Val-Cit-PAB-PNP pictures 2026-07-15 Azido-PEG3-Val-Cit-PAB-PNP
2055047-18-0
 $86.00 10g TargetMol Chemicals Inc.
Azido-PEG3-Val-Cit-PAB-PNP pictures 2025-06-07 Azido-PEG3-Val-Cit-PAB-PNP
2055047-18-0
 100mg >98.00% 100mg Xian confluore Biological Technology Co., Ltd.

2055047-18-0 (Azido-PEG3-Val-Cit-PAB-PNP) Related Search:

Azido-PEG3-S-PEG4-t-butyl ester Azido-PEG3-S-PEG4-propargyl Azdo-PEG3-S-PEG3-Azide Azido-PEG4-NHBoc Azido-PEG3-Val-Cit-PAB-OH
Boc-Val-Cit-PAB-PNP

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Azido-PEG3-Val-Cit-PAB-PNP 4-((14S,17S)-1-Azido-14-isopropyl-12,15-dioxo-17-(3-ureidopropyl)-3,6,9-trioxa-13,16-diazaoctadecan-18-amido)benzyl (4-nitrophenyl) carbonate 2055047-18-0 ADC LINKER