Azido-PEG3-Val-Cit-PAB-PNP manufacturers
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| | Azido-PEG3-Val-Cit-PAB-PNP Basic information |
| | Azido-PEG3-Val-Cit-PAB-PNP Chemical Properties |
| solubility | Soluble in DMSO, DMF | | form | Solid | | color | White to light yellow | | InChIKey | HLBCDJANEWKOSX-XIKWSGLJNA-N | | SMILES | [C@@H](CCCNC(=O)N)(NC(=O)[C@H](C(C)C)NC(=O)CCOCCOCCOCCN=[N+]=[N-])C(=O)NC1C=CC(COC(=O)OC2C=CC(N(=O)=O)=CC=2)=CC=1 |&1:0,11,r| |
| | Azido-PEG3-Val-Cit-PAB-PNP Usage And Synthesis |
| Description | Azido-PEG3-Val-Cit-PAB-PNP is a cleavable peptide ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. PNP groupg is a good leaving group when treating with aminebearing payload. Azido group will react with DBCO, BCN or other Alkyne group through click chemistry, PEG spacer increases aqueous solubility. | | Uses | Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs; Protease Cleavable Linker; Cleavable Linker | | References | [1] Dan N, et al. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel). 2018 Apr 9;11(2). pii: E32. DOI:10.3390/ph11020032
[2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG3-Val-Cit-PAB-PNP Preparation Products And Raw materials |
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