BMS-986195
- CAS No.
- 1912445-55-6
- Chemical Name:
- BMS-986195
- Synonyms
- CPD1640;BMS-986195;BMS-986195 USP/EP/BP;BMS-986195 (BMS986195);Branebrutinib (BMS-986195);Branebrutinib, 10 mM in DMSO;BMS-986195; BMS986195; BMS986195;Branebrutinib (BMS-986195) ，S8832;Inhibitor,BMS-986195,Btk,inhibit,BMS 986195,Bruton tyrosine kinase,Branebrutinib;(S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide
- CBNumber:
- CB83385380
- Molecular Formula:
- C20H23FN4O2
- Molecular Weight:
- 370.42
- MDL Number:
- MFCD31631584
- MOL File:
- 1912445-55-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.32±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility |
DMSO:87.0(Max Conc. mg/mL);234.86(Max Conc. mM) Ethanol:38.0(Max Conc. mg/mL);102.58(Max Conc. mM) |
| form | A crystalline solid |
| pka | 11.91±0.20(Predicted) |
| color | White to off-white |
| InChI | InChI=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18-17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/t13-/m0/s1 |
| InChIKey | VJPPLCNBDLZIFG-ZDUSSCGKSA-N |
| SMILES | N1C2=C(C(N3CCC[C@H](NC(=O)C#CC)C3)=C(F)C=C2C(N)=O)C(C)=C1C |
| FDA UNII | 7LBRZUYSHU |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
BMS-986195 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 33462 | Branebrutinib ≥98% | 1912445-55-6 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 33462 | Branebrutinib ≥98% | 1912445-55-6 | 5mg | $135 | 2026-04-30 | Buy |
| Cayman Chemical | 33462 | Branebrutinib ≥98% | 1912445-55-6 | 10mg | $253 | 2026-04-30 | Buy |
| Cayman Chemical | 33462 | Branebrutinib ≥98% | 1912445-55-6 | 25mg | $420 | 2026-04-30 | Buy |
| ChemScene | CS-0043577 | Branebrutinib 99.78% | 1912445-55-6 | 5mg | $146 | 2026-06-04 | Buy |
BMS-986195 Chemical Properties, Uses, Production
Uses
Branebrutinib (BMS-986195) is a potent inhibitor of BTK with IC50 values of 0.1 nM, 0.9 nM, 1.5 nM, 5 nM for BTK, TEC, BMX, TXK, respectively.
Uses
Branebrutinib (BMS-986195) is a highly potent, selective covalent, irreversible inhibitor of Bruton’s tyrosine kinase (BTK), with an IC50 of 0.1 nM[1][2]. Branebrutinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo
In mice, BMS-986195 demonstrates robust efficacy in murine models of RA including CIA and CAIA, protecting against clinically evident disease, histologic joint damage and bone mineral density loss. In both mice and monkeys, maximal efficacy is observed at doses ≤0.5 mg/kg PO QD, which achieves ≥95% inactivation of BTK in vivo. At similar doses, BMS-986195 is also highly protective against nephritis in the NZB/W mouse model of lupus. To investigate the dynamics of BTK inactivation and resynthesis of BTK, cynomolgus monkeys are given single or multiple doses of BMS-986195. 100% peak inactivation of BTK is obtained with a single administration of BMS-986195 at 0.5 mg/kg PO[1].
References
[1] JR Burke, et al. BMS-986195 Is a Highly Selective and Rapidly Acting Covalent Inhibitor of Bruton’s Tyrosine Kinase with Robust Efficacy at Low Doses in Preclinical Models of RA and Lupus Nephritis. 2017 ACR/ARHP Annual Meeting, September 18, 2017.
[2] Watterson SH, et al. Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK). J Med Chem. 2019 Apr 11;62(7):3228-3250. DOI:10.1021/acs.jmedchem.9b00167
BMS-986195 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 15000803246 18149758185 | sales-cpd@caerulumpharma.com | China | 478 | 58 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4865 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 87240 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2958 | 58 |
View Latest Price from BMS-986195 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-03 | Branebrutinib
1912445-55-6
|
$108.00-355.00 | 99.39% | 10g | TargetMol Chemicals Inc. |
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- Branebrutinib
1912445-55-6
- $108.00-355.00
- 99.39%
- TargetMol Chemicals Inc.
