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1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE

1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE structure

CAS No.

Chemical Name:: 1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE

Synonyms: INHIBITOR I;Z-L-NHNHCONHNH-LF-NH2;CATHEPSIN K INHIBITOR III;1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE

CBNumber:: CB8346744

Molecular Formula:: C30H43N7O6

Molecular Weight:: 597.71

MDL Number:: MFCD06411403

MOL File:: Mol file

Last updated:2026-01-13 13:16:59

Request For Quotation

1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Properties

storage temp.	-20°C
solubility	DMSO: 1mg/mL
form	lyophilized solid
color	white
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	WGK 1
Storage Class	11 - Combustible Solids

1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	INB0002517	1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE 95.00%		5MG	$505.79	2021-12-16	Buy

Product number	Packaging	Price	Buy
INB0002517	5MG	$505.79	Buy

1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Chemical Properties,Uses,Production

Uses

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (K_i,app = 9.7 nM). At higher concentrations, also inhibits the activities of cathepsin L, cathepsin B, and papain (K_i,app = 120 nM, 5.1 µM, and 2.3 µM, respectively). Completely blocks cathepsin K activity in primary human synovial fibroblast cultures at 1 µM.
A cell-permeable, potent, selective, reversible inhibitor of cathepsin K (K_i,app = 9.7 nM). At higher concentrations also inhibits the activities of cathepsin L, cathepsin B, and papain (K_i,app = 120 nM, 5.1 mM, and 2.3 µM, respectively). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM.

Biological Activity

Cell permeable: yes', 'Primary Target
Cathepsin K', 'Product does not compete with ATP.', 'Reversible: yes', 'Target Ki: 9.7 nM against cathepsin K

1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Preparation Products And Raw materials

Raw materials

Preparation Products

1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Merck KGaA	--	ordercn@merckgroup.com	China	6376	58
EMD Biosciences, Inc.	--	technical@calbiochem.com	United States	6527	66

Supplier	Advantage
Merck KGaA	58
EMD Biosciences, Inc.	66

(1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE)Related Search:

Carbohydrazide

1-(N-BENZYLOXYCARBONYL-LEUCYL)-5-(PHENYLALANYL-LEUCYL)CARBOHYDRAZIDE CATHEPSIN K INHIBITOR III INHIBITOR I Z-L-NHNHCONHNH-LF-NH2