3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde
- CAS No.
- 19881-70-0
- Chemical Name:
- 3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde
- Synonyms
- 104523;Windorphen;SALOR-INT L161004-1EA;Windorphen >=98% (HPLC);Windorphen, 10 mM in DMSO;Windorphen, Inactive Control;Windorphen - CAS 19881-70-0 - Calbiochem;3-CHLORO-2,3-DI(4-METHOXYPHENYL)ACRYLALDEHYDE;(Z)-3-chloro-2,3-bis(4-methoxyphenyl)acrolein;3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde
- CBNumber:
- CB8372871
- Molecular Formula:
- C17H15ClO3
- Molecular Weight:
- 302.75
- MDL Number:
- MFCD26940341
- MOL File:
- 19881-70-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 160-163°C |
|---|---|
| Boiling point | 468.1±45.0 °C(Predicted) |
| Density | 1.198±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| form | powder |
| color | white to beige |
| InChI | 1S/C17H15ClO3/c1-20-14-7-3-12(4-8-14)16(11-19)17(18)13-5-9-15(21-2)10-6-13/h3-11H,1-2H3/b17-16- |
| InChIKey | VNRALGZMXHFBPG-MSUUIHNZSA-N |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| WGK Germany | 3 |
|---|---|
| HazardClass | IRRITANT |
| Storage Class | 11 - Combustible Solids |
3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.09164 | Windorphen - CAS 19881-70-0 - Calbiochem | 19881-70-0 | 25mg | $225 | 2023-01-07 | Buy |
| Sigma-Aldrich | SML0899 | Windorphen ≥98% (HPLC) | 19881-70-0 | 5mg | $111 | 2022-05-15 | Buy |
| ChemScene | CS-0087500 | Windorphen 99.75% | 19881-70-0 | 5mg | $54 | 2026-06-04 | Buy |
| ChemScene | CS-0087500 | Windorphen 99.75% | 19881-70-0 | 10mg | $81 | 2026-06-04 | Buy |
| ChemScene | CS-0087500 | Windorphen 99.75% | 19881-70-0 | 25mg | $141 | 2026-06-04 | Buy |
3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde Chemical Properties, Uses, Production
Uses
Windorphen is a selective inhibitor of p300 histone acetyltransferase, a coactivator that associates withβ-catenin,blocking the Wnt signal required for ventral development.
Biological Activity
windorphen is a wnt inhibitor that selectively abrogates the wnt signaling for ventral development.wnt protein is a family of signaling proteins that interacts on the wnt/β-catenin pathways during embryotic development, cell proliferation, migration and adult tissue homeostasis.in canonical wnt/β-catenin reporter cell line stf293, windorphen dose-dependently inhibits wnt3a-inducible topflash-luciferase activity (ic50 of 1.5 mm). in human colon adenocarcinomasw480 cells with defective apc gene that constitutively activates wnt signaling, 72 h treatment of windorphen causes a wide spread apoptosis. [1]in zebrafish embryos, windorphen leads to apparent expansion of the dorsal markers (pax2.1) and marker of rhombomeres 3 and 5 at the six-somite stage (krox0). windorphen selectively inhibits wnt signaling in ventral and lateral regions of the 50% epiboly stage embryo (5.3 hpf). in addition, windoprhen treatment rescues the telencephalon/eye phenotype in the mbl mutant zebrafish (i.e. a defective axin1/β-catenin destruction complex causes abnormal activation of wnt signaling and the loss of telencephalon and eyes.) [1]
References
1. hao j, ao a, zhou l et al. selective small molecule targeting β-catenin function discovered by invivo chemical genetic screen. cell rep. 2013 sep 12;4(5):898-904.
3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| ChemShuttle, Inc. | 0510-83588313-811 18800520310 | sales@chemshuttle.com | China | 2999 | 62 |
| Wuhan Kaymke Chemical Co., Ltd., | 027-87342388 18086026008 | sales@kaymke.com | China | 3537 | 55 |
| Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd. | 0515-89701588 13770166955 | orgunion@orgunion.com | China | 620 | 55 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Zhengzhou Alfachem Co., Ltd. | 0371-53765687 18937137882 | 3969243885@qq.com | China | 7734 | 55 |
| Yancheng KangdiSen Pharmaceutical Co., Ltd. | 13812573443;18052965989 | tongbenwan22@163.com | China | 1975 | 55 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2308 | 55 |
View Latest Price from 3-Chloro-2,3-bis(4-methoxyphenyl)acrylaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-06 | Windorphen
19881-70-0
|
$36.00-95.00 | 99.96% | 10g | TargetMol Chemicals Inc. |
-
- Windorphen
19881-70-0
- $36.00-95.00
- 99.96%
- TargetMol Chemicals Inc.
