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Leu-enkephalin amide

Leu-enkephalin amide structure

CAS No.: 60117-24-0

Chemical Name:: Leu-enkephalin amide

Synonyms: YGGFL-NH2;NSC 351912;LEU-ENKEPHALIN NH2;enkephalinamide-leu;Leu-enkephalin amide;TYR-GLY-GLY-PHE-LEU-NH2;[LEU5]-ENKEPHALIN AMIDE;DYNORPHIN A (1-5) AMIDE;leucine enkephalinamide;H-TYR-GLY-GLY-PHE-LEU-NH2

CBNumber:: CB8373676

Molecular Formula:: C28H38N6O6

Molecular Weight:: 554.64

MDL Number:: MFCD00076407

MOL File:: 60117-24-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:55:42

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Leu-enkephalin amide Properties

Melting point	123-126 °C
Boiling point	1012.8±65.0 °C(Predicted)
Density	1.254±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	Soluble in DMSO
pka	9.97±0.15(Predicted)
form	Solid
color	White to off-white
Sequence	Tyr-Gly-Gly-Phe-Leu-NH2

SAFETY

Risk and Safety Statements

WGK Germany	3

Leu-enkephalin amide price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	FL108764	Leu-Enkephalin amide acetate salt	60117-24-0	100mg	$900	2026-06-04	Buy
Biosynth	FL108764	Leu-Enkephalin amide acetate salt	60117-24-0	50mg	$900	2026-06-04	Buy
Biosynth	FL108764	Leu-Enkephalin amide acetate salt	60117-24-0	25mg	$900	2026-06-04	Buy
Biosynth	FL108764	Leu-Enkephalin amide acetate salt	60117-24-0	250mg	$1480	2026-06-04	Buy
Biosynth	FL108764	Leu-Enkephalin amide acetate salt	60117-24-0	500mg	$2570	2026-06-04	Buy

Product number	Packaging	Price	Buy
FL108764	100mg	$900	Buy
FL108764	50mg	$900	Buy
FL108764	25mg	$900	Buy
FL108764	250mg	$1480	Buy
FL108764	500mg	$2570	Buy

Leu-enkephalin amide Chemical Properties, Uses, Production

Uses

[Leu5]-Enkephalin, amide is a δ opioid receptor agonist.

in vivo

Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05)^[1].

References

[1] Hurley RW, et al. Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci. 2001 Apr 1;21(7):2536-45. DOI:10.1523/JNEUROSCI.21-07-02536.2001
[2] Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8. DOI:10.1111/j.1476-5381.1987.tb11323.x

Leu-enkephalin amide Preparation Products And Raw materials

Raw materials

Preparation Products

Leu-enkephalin amide Suppliers

Global Suppliers ( 77)

Supplier	Tel	Email	Country	ProdList	Advantage
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632;	sales@reading-chemicals.com	China	15165	58
Creative Peptides		info@creative-peptides.com	United States	6083	56
Beijing Solarbio Science & Tecnology Co., Ltd.	17801761073 18101056239	3193328036@qq.com	China	28150	68
Nanjing Leon Biological Technology Co., Ltd.	025-84523390 -127; 17705183659	sales@njleonbiotech.com	China	5501	55
Nanjing Peptide Biotech Ltd.	025-58361106-805 15951641583	zhao.xu@njpeptide.com	China	9976	55
Chengdu Youngshe Chemical Co., Ltd.	+86-17380623303	Caroline@youngshechem.com	China	4725	58
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919 15967184799	Eric@peptidego.com	China	7872	58

Supplier	Advantage
GL Biochem (Shanghai) Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58
Creative Peptides	56
Beijing Solarbio Science & Tecnology Co., Ltd.	68
Nanjing Leon Biological Technology Co., Ltd.	55
Nanjing Peptide Biotech Ltd.	55
Chengdu Youngshe Chemical Co., Ltd.	58
Hangzhou Peptidego Biotech Co.,Ltd.	58

View Latest Price from Leu-enkephalin amide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-19	LEU-ENKEPHALIN AMIDE 60117-24-0	$7.00	1KG	99%	100kg	Career Henan Chemical Co

LEU-ENKEPHALIN AMIDE
60117-24-0
$7.00
99%
Career Henan Chemical Co

60117-24-0 (Leu-enkephalin amide) Related Search:

Met-enkephalinamide PACAP (1-27), human, ovine, rat (TFA) MM 54 CYT-1010 H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-OH

H-Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2 Bay 55-9837 Dynorphin A (1-13) Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2 [LEU5]-ENKEPHALIN

DYNORPHIN B Beta-Neoendorphin Tyr-Gly-Gly-Phe-Leu-Arg-Phe-NH2 H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-OH Leu-enkephalin-Arg-Phe

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1of4

ALPHA-NEOENDORPHIN (1-5) AMIDE leucine enkephalinamide acetate DYNORPHIN A (1-5) AMIDE DYNORPHIN A (1-5) AMIDE ACETATE SALT H-TYR-GLY-GLY-PHE-LEU-NH2 H-TYR-GLY-GLY-PHE-LEU-NH2 ACETATE SALT LEU-ENKEPHALIN NH2 [LEU5]-ENKEPHALIN AMIDE enkephalinamide-leu YGGFL-NH2 TYR-GLY-GLY-PHE-LEU-NH2 leucine enkephalinamide 4-Hydroxy-L-Phe-Gly-Gly-Phe-Leu-NH2 L-Tyr-Gly-Gly-L-Phe-L-Leu-NH2 a-Neoendorphin (1-5) aMide, Dynorphin A (1-5) aMide Leu-Enkephalin amide,α-Neoendorphin (1-5) amide Leu-Enkephalin amide acetate salt L-Leucinamide, L-tyrosylglycylglycyl-L-phenylalanyl- NSC 351912 Leu-Enkephalin amide acetate salt H-Tyr-Gly-Gly-Phe-Leu-NH2 acetate salt Leu-enkephalin amide 60117-24-0 C28H38N6O6 Biochemicals and Reagents Amino Acids and Peptides BioChemical Enkephalins Peptides Opioid Peptides