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Leu-enkephalin amide

Leu-enkephalin amide Structure
Leu-enkephalin amide structure
CAS No.
60117-24-0
Chemical Name:
Leu-enkephalin amide
Synonyms
YGGFL-NH2;NSC 351912;LEU-ENKEPHALIN NH2;enkephalinamide-leu;Leu-enkephalin amide;TYR-GLY-GLY-PHE-LEU-NH2;[LEU5]-ENKEPHALIN AMIDE;DYNORPHIN A (1-5) AMIDE;leucine enkephalinamide;H-TYR-GLY-GLY-PHE-LEU-NH2
CBNumber:
CB8373676
Molecular Formula:
C28H38N6O6
Molecular Weight:
554.64
MDL Number:
MFCD00076407
MOL File:
60117-24-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:42
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Leu-enkephalin amide Properties

Melting point 123-126 °C
Boiling point 1012.8±65.0 °C(Predicted)
Density 1.254±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility Soluble in DMSO
pka 9.97±0.15(Predicted)
form Solid
color White to off-white
Sequence Tyr-Gly-Gly-Phe-Leu-NH2

SAFETY

Risk and Safety Statements

WGK Germany  3

Leu-enkephalin amide price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FL108764 Leu-Enkephalin amide acetate salt 60117-24-0 100mg $900 2026-06-04 Buy
Biosynth FL108764 Leu-Enkephalin amide acetate salt 60117-24-0 50mg $900 2026-06-04 Buy
Biosynth FL108764 Leu-Enkephalin amide acetate salt 60117-24-0 25mg $900 2026-06-04 Buy
Biosynth FL108764 Leu-Enkephalin amide acetate salt 60117-24-0 250mg $1480 2026-06-04 Buy
Biosynth FL108764 Leu-Enkephalin amide acetate salt 60117-24-0 500mg $2570 2026-06-04 Buy
Product number Packaging Price Buy
FL108764 100mg $900 Buy
FL108764 50mg $900 Buy
FL108764 25mg $900 Buy
FL108764 250mg $1480 Buy
FL108764 500mg $2570 Buy

Leu-enkephalin amide Chemical Properties, Uses, Production

Uses

[Leu5]-Enkephalin, amide is a δ opioid receptor agonist.

in vivo

Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05)[1].

References

[1] Hurley RW, et al. Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci. 2001 Apr 1;21(7):2536-45. DOI:10.1523/JNEUROSCI.21-07-02536.2001
[2] Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8. DOI:10.1111/j.1476-5381.1987.tb11323.x

Leu-enkephalin amide Preparation Products And Raw materials

Raw materials

Preparation Products

Leu-enkephalin amide Suppliers

Global Suppliers ( 76)
Supplier Tel Email Country ProdList Advantage
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Creative Peptides info@creative-peptides.com United States 6083 56
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 28150 68
Nanjing Leon Biological Technology Co., Ltd. 025-84523390 -127; 17705183659 sales@njleonbiotech.com China 5501 55
Nanjing Peptide Biotech Ltd. 025-58361106-805 15951641583 zhao.xu@njpeptide.com China 9976 55
Chengdu Youngshe Chemical Co., Ltd. +86-17380623303 Caroline@youngshechem.com China 4725 58
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 15967184799 Eric@peptidego.com China 7872 58
Supplier Advantage
GL Biochem (Shanghai) Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Creative Peptides 56
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Nanjing Leon Biological Technology Co., Ltd. 55
Nanjing Peptide Biotech Ltd. 55
Chengdu Youngshe Chemical Co., Ltd. 58
Hangzhou Peptidego Biotech Co.,Ltd. 58

View Latest Price from Leu-enkephalin amide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
LEU-ENKEPHALIN AMIDE pictures 2020-02-19 LEU-ENKEPHALIN AMIDE
60117-24-0
 $7.00 1KG 99% 100kg Career Henan Chemical Co

60117-24-0 (Leu-enkephalin amide) Related Search:

Met-enkephalinamide PACAP (1-27), human, ovine, rat (TFA) MM 54 CYT-1010 H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-OH
H-Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2 Bay 55-9837 Dynorphin A (1-13) Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH2 [LEU5]-ENKEPHALIN
DYNORPHIN B Beta-Neoendorphin Tyr-Gly-Gly-Phe-Leu-Arg-Phe-NH2 H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-OH Leu-enkephalin-Arg-Phe
Dynorphin a (1-10) amide Leu-enkephalin-Arg H-Tyr-Gly-Gly-Phe-Leu-D-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH

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ALPHA-NEOENDORPHIN (1-5) AMIDE leucine enkephalinamide acetate DYNORPHIN A (1-5) AMIDE DYNORPHIN A (1-5) AMIDE ACETATE SALT H-TYR-GLY-GLY-PHE-LEU-NH2 H-TYR-GLY-GLY-PHE-LEU-NH2 ACETATE SALT LEU-ENKEPHALIN NH2 [LEU5]-ENKEPHALIN AMIDE enkephalinamide-leu YGGFL-NH2 TYR-GLY-GLY-PHE-LEU-NH2 leucine enkephalinamide 4-Hydroxy-L-Phe-Gly-Gly-Phe-Leu-NH2 L-Tyr-Gly-Gly-L-Phe-L-Leu-NH2 a-Neoendorphin (1-5) aMide, Dynorphin A (1-5) aMide Leu-Enkephalin amide,α-Neoendorphin (1-5) amide Leu-Enkephalin amide acetate salt L-Leucinamide, L-tyrosylglycylglycyl-L-phenylalanyl- NSC 351912 Leu-Enkephalin amide acetate salt H-Tyr-Gly-Gly-Phe-Leu-NH2 acetate salt Leu-enkephalin amide 60117-24-0 C28H38N6O6 Biochemicals and Reagents Amino Acids and Peptides BioChemical Enkephalins Peptides Opioid Peptides