4-Piperidinoaniline
- CAS No.
- 2359-60-6
- Chemical Name:
- 4-Piperidinoaniline
- Synonyms
- 4-(1-Piperidinyl)aniline;AKOS B033030;AKOS BB-8563;ASISCHEM V33555;BUTTPARK 97\12-13;TIMTEC-BB SBB010087;4-PIPERIDINOANILINE;4-(1-pieridino)aniline;LABOTEST-BB LT00455366;4-Piperidinoaniline,98%
- CBNumber:
- CB8397993
- Molecular Formula:
- C11H16N2
- Molecular Weight:
- 176.26
- MDL Number:
- MFCD00051688
- MOL File:
- 2359-60-6.mol
- MSDS File:
- SDS
| Melting point | 26-29 °C(lit.) |
|---|---|
| Boiling point | 140-142°C 1mm |
| Density | 1.074±0.06 g/cm3(Predicted) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| pka | 7.79±0.10(Predicted) |
| form | low melting solid |
| color | Brown to black |
| BRN | 139525 |
| InChI | 1S/C11H16N2/c12-10-4-6-11(7-5-10)13-8-2-1-3-9-13/h4-7H,1-3,8-9,12H2 |
| InChIKey | TVOSOIXYPHKEAR-UHFFFAOYSA-N |
| SMILES | Nc1ccc(cc1)N2CCCCC2 |
| CAS DataBase Reference | 2359-60-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-36/37-20/21/22 | |||||||||
| Safety Statements | 26-36-36/37/39-22 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Piperidinoaniline price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 556629 | N-(4-Aminophenyl)piperidine 97% | 2359-60-6 | 1g | $53.2 | 2023-06-20 | Buy |
| Activate Scientific | AS20277-A | 4-Piperidinoaniline 97% | 2359-60-6 | 1g | $27 | 2026-06-04 | Buy |
| Activate Scientific | AS20277-A | 4-Piperidinoaniline 97% | 2359-60-6 | 5g | $57 | 2026-06-04 | Buy |
| Activate Scientific | AS20277-A | 4-Piperidinoaniline 97% | 2359-60-6 | 25g | $86 | 2026-06-04 | Buy |
| Matrix Scientific | 051251 | 4-(1-Piperidinyl)aniline | 2359-60-6 | 500.00mg | $237 | 2026-05-18 | Buy |
4-Piperidinoaniline Chemical Properties, Uses, Production
Uses
Reactant for synthesis of:
- Amino acid arylamides
- Selective interleukin-2 inducible T-cell inhibitors
- Antimalarial drugs
- Aglycoristocetin derivatives for anti-influenza virus activity
- IRAK-4 inhibitors
- 9-Aminoacridines with antiprion activity
Synthesis
6574-15-8
2359-60-6
The general procedure for the synthesis of 1-(4-nitrophenyl)piperidine was as follows: first, 4-fluoronitrobenzene (323 mg, 2.3 mmol) was dissolved in DMSO (5 mL), followed by the addition of potassium carbonate (475 mg, 3.5 mmol) and piperidine (460 μL, 4.6 mmol). The reaction mixture was stirred at 90 °C for 9 hours. After completion of the reaction, water was added to the reaction solution and extracted twice with ethyl acetate. The organic layers were combined and washed twice with saturated aqueous NaCl followed by drying with anhydrous Na2CO3. The solvent was evaporated under reduced pressure to give 1-(4-nitrophenyl)piperidine (Y197, yield: 472 mg, 100%). Next, Y197 (472 mg) was dissolved in ethyl acetate (20 mL), Pd/C (186 mg) was added, and the reaction was stirred for 3 h at room temperature under hydrogen atmosphere. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: chloroform:methanol = 40:1) to afford 1-(4-aminophenyl)piperidine (Y222, yield: 394 mg, quantitative). Finally, Y491 (80 mg, 0.18 mmol) was dissolved in dichloromethane (2 mL), Y222 (100 mg, 0.58 mmol) was added and stirred at room temperature for 5 hours. After the reaction was completed, the solvent was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: chloroform:methanol = 35:1) to afford the target product 1-(p-aminophenyl)piperidine (yield: 68 mg, 64%). The structure of the product was confirmed by 1H NMR, 13C NMR and HRMS.1H NMR (500 MHz, CDCl3) δ 8.40 (s, 1H), 8.0 (d, 1H, J = 8.0 Hz), 7.70 (d, 1H, J = 8.5 Hz), 7.52 (dd, 1H, J = 8.0, 7.5 Hz), 6.92 (dd, 2H, J = 9.0, 3.5 Hz), 6.92 (dd, 2H, J = 9.0, 3.5 Hz). = 9.0, 3.5 Hz), 6.77 (dd, 2H, J = 9.0, 6.5 Hz), 5.33 (t, 1H, J = 6.0 Hz), 4.07 (bs, 2H), 3.11-3.09 (m, 4H), 2.79-2.64 (m, 4H), 1.69-1.53 (m, 10H), 1.43 (s, 9H), 1.09-1.01 (m, 9H) 1.09-1.01 (m, 2H).13C NMR (125 MHz, CDCl3) δ 154.9, 141.6, 140.8, 131.4, 130.9, 129.8, 125.8, 125.7, 79.7, 77.4, 48.7, 36.6, 29.6, 28.6, 25.7, 24.2.HRMS ( FAB-) m/z: [M-H]- calculated value C28H39N4O6S2, 591.2311; measured value, 591.2324.
References
[1] Patent: US2013/45977, 2013, A1. Location in patent: Paragraph 0211; 0212; 0213; 0214
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 15, p. 3057 - 3061
[3] Patent: US2009/239848, 2009, A1. Location in patent: Page/Page column 25
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 12, p. 4849 - 4859
[5] Patent: CN105503775, 2016, A. Location in patent: Paragraph 0042
