1,6-NAPHTHYRIDINE
- CAS No.
- 253-72-5
- Chemical Name:
- 1,6-NAPHTHYRIDINE
- Synonyms
- Naphthyridine;6-Naphthyridine;1,6-PHTHYRIDINE;1,6-naphthhydrine;1,6-NAPHTHYRIDINE;1,6-Pyridopyridine;1,6-Naphthylridine;1,6-DIAZANAPHTHALENE;PYRIDO[4,3-B]PYRIDINE;1,6-NAPHTHYRIDINE 96+%
- CBNumber:
- CB8404040
- Molecular Formula:
- C8H6N2
- Molecular Weight:
- 130.15
- MDL Number:
- MFCD00059750
- MOL File:
- 253-72-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| [1,6]Naphthyridine Aldrich | ADE000839 | 1g | $463 |
| 1,6-Naphthyridine >97.0%(T) | N0462 | 100mg | $49 |
| 1,6-Naphthyridine >97.0%(T) | N0462 | 1g | $291 |
| 1,6-Naphthyridine | W4869 | 500mg | $299 |
| [1,6]Naphthyridine 95% | 3H32-1-29 | 1g | $376 |
| More product size | |||
| Melting point | 231-233°C |
|---|---|
| Boiling point | 267.3±13.0 °C(Predicted) |
| Density | 1.183±0.06 g/cm3(Predicted) |
| Flash point | 35 °C |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.70±0.10(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| CAS DataBase Reference | 253-72-5(CAS DataBase Reference) |
| FDA UNII | S1T14P7OW7 |
| EPA Substance Registry System | 1,6-Naphthyridine (253-72-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
1,6-NAPHTHYRIDINE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000839 | [1,6]Naphthyridine Aldrich | 253-72-5 | 1g | $463 | 2023-01-07 | Buy |
| TCI Chemical | N0462 | 1,6-Naphthyridine >97.0%(T) | 253-72-5 | 100mg | $49 | 2025-07-31 | Buy |
| TCI Chemical | N0462 | 1,6-Naphthyridine >97.0%(T) | 253-72-5 | 1g | $291 | 2025-07-31 | Buy |
| AK Scientific | W4869 | 1,6-Naphthyridine | 253-72-5 | 500mg | $299 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H32-1-29 | [1,6]Naphthyridine 95% | 253-72-5 | 1g | $376 | 2021-12-16 | Buy |
1,6-NAPHTHYRIDINE Chemical Properties,Uses,Production
Uses
1,5-Diazonaphthalene is a pharmaceutical intermediate that can be prepared from 4-aminopyridine as a starting material and can be used to prepare CXCR4 inhibitors.
Definition
ChEBI: 1,6-naphthyridine is a naphthyridine.
Synthesis
504-24-5
107-21-1
253-72-5
The general procedure for the synthesis of 1,6-naphthyridine from 4-aminopyridine and ethylene glycol was as follows: first, a sulfuric acid solution was prepared by slowly adding 100 mL of concentrated sulfuric acid to 57 mL of water cooled in an ice bath. Subsequently, 33 mL of glycerol (457 mmol), 48 g of m-nitrobenzenesulfonic acid sodium salt (212 mmol), and 10 g of 4-aminopyridine (106 mmol) were sequentially added to this solution. The reaction mixture was heated to reflux at 135 °C for 4 hours. Upon completion of the reaction, the cooled reaction mixture was alkalized with 500 mL of 2.5 N sodium hydroxide solution and cooled in an ice bath. Subsequently, extraction was performed with dichloromethane (3 x 200 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give an oil. The oily substance was purified by column chromatography (5% methanol/dichloromethane as eluent) to give 5.04 g (36% yield) of dark orange oily product. For the preparation of analytical samples, the product was converted to HCl salt and recrystallized from ethyl acetate to give an orange low melting point solid. Mass spectrometry analysis showed a molecular ion peak m/z 130 (M+). Ref: Chem Pharm Bull. 1971, 19, 9, 1751-1755.
References
[1] Patent: EP1147083, 2004, B1. Location in patent: Page 47
1,6-NAPHTHYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14343 | 58 |
View Lastest Price from 1,6-NAPHTHYRIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 1,6-NAPHTHYRIDINE
253-72-5
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-02-17 | 1,6-naphthyridine
253-72-5
|
US $1.00 / KG | 1KG | 98% HPLC | 10 tons | Career Henan Chemical Co |
-
- 1,6-NAPHTHYRIDINE
253-72-5
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 1,6-naphthyridine
253-72-5
- US $1.00 / KG
- 98% HPLC
- Career Henan Chemical Co
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