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H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt

H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt Structure
H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt structure
CAS No.
23815-89-6
Chemical Name:
H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt
Synonyms
RPPGF;1-5-Bradykinin;BRADYKININ (1-5);ARG-PRO-PRO-GLY-PHE;1-5-Bradykinin (9CI);Arg-Pro-Pro-Gly-Phe-OH;39: PN: WO0112656 SEQID;BRADYKININ FRAGMENT 1-5;H-Arg-Pro-Pro-Gly-Phe-OH;ARG-PRO-PRO-GLY-PHE ACETATE
CBNumber:
CB8420710
Molecular Formula:
C27H40N8O6
Molecular Weight:
572.66
MDL Number:
MFCD00076260
MOL File:
23815-89-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:43
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H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt Properties

Density 1.46±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO
pka 3.50±0.10(Predicted)
form Solid
color White to off-white
Sequence Arg-Pro-Pro-Gly-Phe
InChIKey USSUMSBPLJWFSZ-UHFFFAOYSA-N
SMILES NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(O)=O
UNSPSC Code 12352200
NACRES NA.32

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 11 - Combustible Solids

H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B1401 Bradykinin Fragment 1-5 ≥97% (HPLC) 23815-89-6 1mg $89.3 2026-04-30 Buy
Sigma-Aldrich B1401 Bradykinin Fragment 1-5 ≥97% (HPLC) 23815-89-6 5mg $314 2026-04-30 Buy
Biosynth PB16922 Bradykinin (1-5) 23815-89-6 1mg $150 2026-06-04 Buy
Biosynth PB16922 Bradykinin (1-5) 23815-89-6 10mg $150 2026-06-04 Buy
Biosynth PB16922 Bradykinin (1-5) 23815-89-6 100mg $241 2026-06-04 Buy
Product number Packaging Price Buy
B1401 1mg $89.3 Buy
B1401 5mg $314 Buy
PB16922 1mg $150 Buy
PB16922 10mg $150 Buy
PB16922 100mg $241 Buy

H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt Chemical Properties, Uses, Production

Uses

Biologically active fragment of bradykinin

Biochem/physiol Actions

The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.

in vivo

Bradykinin is a short-lived vasoactive peptide, with a reported half-life in vivo of 17 s, that is rapidly metabolized in the circulation to Bradykinin (1-5). Bradykinin (1-5), the product of two sequential cleavages of Bradykinin by ACE at the Pro7-Phe8 and Phe5-Ser6bonds, has been identified as the major stable metabolite of Bradykinin in vivo in human subjects, with a terminal half-life of minutes. Both Bradykinin and Bradykinin (1-5) inhibit α- and γ-thrombin-induced platelet aggregation (P<0.01 versus baseline). Bradykinin (1-5) inhibits γ-thrombin-induced platelet aggregation 50% at a calculated dose of 183±3 pmol/min. Neither Bradykinin nor Bradykinin (1-5) affects thrombin receptor-activating peptide-induced platelet aggregation, consistent with the hypothesis that Bradykinin and Bradykinin 1-5 inhibit thrombin-induced platelet aggregation by preventing cleavage of the thrombin receptor and liberation of thrombin receptor-activating peptide. Bradykinin (1-5) significantly attenuates α-thrombin-induced platelet aggregation but not TRAP 1-6-induced platelet aggregation. Bradykinin (1-5) potently inhibits γ-thrombin (500 nM)-induced platelet aggregation with an ED50 of 183±2 pmol/min[1].

H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt Preparation Products And Raw materials

Raw materials

Preparation Products

H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt Suppliers

Global Suppliers ( 119)
Supplier Tel Email Country ProdList Advantage
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9331 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Supplier Advantage
GL Biochem (Shanghai) Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
MedChemexpress LLC 58
Guangzhou Isun Pharmaceutical Co., Ltd 55
Bide Pharmatech Ltd. 60
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Finetech Industry Limited 58
Sigma-Aldrich 80

View Latest Price from H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bradykinin (1-5) pictures 2026-07-16 Bradykinin (1-5)
23815-89-6
 $42.00 10g TargetMol Chemicals Inc.
H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT pictures 2026-07-10 H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT
23815-89-6
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
ARG-PRO-PRO-GLY-PHE pictures 2020-02-17 ARG-PRO-PRO-GLY-PHE
23815-89-6
 $7.00 1KG 99% 100KG Career Henan Chemical Co

23815-89-6 (H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt) Related Search:

ANGIOTENSIN 1/2 + A (2 - 8) ANGIOTENSIN III, HUMAN (SAR1,ILE4,8)-ANGIOTENSIN II Angiogenin (108-122) TFA (DES-ASP1,ILE8)-ANGIOTENSIN II
Angiotensin acetate ANGIOTENSIN II, HUMAN Abz-Gly-4-nitro-Phe-Pro-OH H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-OH acetate salt Angiotensinogen (1-13) (human)
Angiotensin I/II (1-6) Bradykinin (1-6) Angiotensin I/II (3-7) Angiotensin I/II (4-8) H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH
Angiotensin I/II (1-5) Asp-Arg-Val-Tyr H-Met-Lys-Arg-Ser-Arg-Gly-Pro-Ser-Pro-Arg-Arg-OH

1of4

RPPGF ARG-PRO-PRO-GLY-PHE ARG-PRO-PRO-GLY-PHE ACETATE BRADYKININ (1-5) BRADYKININ FRAGMENT 1-5 H-ARG-PRO-PRO-GLY-PHE-OH TFA H-Arg-Pro-Pro-Gly-Phe-OH Arg-Pro-Pro-Gly-Phe-OH L-Arg-L-Pro-L-Pro-Gly-L-Phe-OH 1-5-Bradykinin 39: PN: WO0112656 SEQID Bradykinin (1-5) trifluoroacetate salt H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt Bradykinin Fragment 1-5, ≥97% (HPLC) N5-(Diaminomethylene)-L-ornithyl-L-prolyl-L-prolylglycyl-L-phenylalanine 1-5-Bradykinin (9CI) (S)-2-(2-((S)-1-((S)-1-((S)-2-Amino-5-guanidinopentanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamido)acetamido)-3-phenylpropanoic acid Bradykinin Fragment 1-5，TFA H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt 23815-89-6 C27H40N8O6 Bradykinins Amino Acids and Peptides Biochemicals and Reagents BioChemical Peptides Peptide