H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT

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H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT manufacturers

  • ARG-PRO-PRO-GLY-PHE
  • ARG-PRO-PRO-GLY-PHE pictures
  • $7.00
  • 2020-02-17
  • CAS:23815-89-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100KG
H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT Basic information
Product Name:H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT
Synonyms:RPPGF;ARG-PRO-PRO-GLY-PHE;ARG-PRO-PRO-GLY-PHE ACETATE;BRADYKININ (1-5);BRADYKININ FRAGMENT 1-5;H-ARG-PRO-PRO-GLY-PHE-OH TFA;H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT;H-Arg-Pro-Pro-Gly-Phe-OH
CAS:23815-89-6
MF:C27H40N8O6
MW:572.66
EINECS:
Product Categories:Peptide
Mol File:23815-89-6.mol
H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT Structure
H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT Chemical Properties
density 1.46±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO
pka3.50±0.10(Predicted)
form Solid
color White to off-white
SequenceArg-Pro-Pro-Gly-Phe
InChIKeyUSSUMSBPLJWFSZ-UHFFFAOYSA-N
SMILESNC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(O)=O
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
SigmaAldrich English
H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT Usage And Synthesis
UsesBiologically active fragment of bradykinin
Biochem/physiol ActionsThe bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.
in vivo

Bradykinin is a short-lived vasoactive peptide, with a reported half-life in vivo of 17 s, that is rapidly metabolized in the circulation to Bradykinin (1-5). Bradykinin (1-5), the product of two sequential cleavages of Bradykinin by ACE at the Pro7-Phe8 and Phe5-Ser6bonds, has been identified as the major stable metabolite of Bradykinin in vivo in human subjects, with a terminal half-life of minutes. Both Bradykinin and Bradykinin (1-5) inhibit α- and γ-thrombin-induced platelet aggregation (P<0.01 versus baseline). Bradykinin (1-5) inhibits γ-thrombin-induced platelet aggregation 50% at a calculated dose of 183±3 pmol/min. Neither Bradykinin nor Bradykinin (1-5) affects thrombin receptor-activating peptide-induced platelet aggregation, consistent with the hypothesis that Bradykinin and Bradykinin 1-5 inhibit thrombin-induced platelet aggregation by preventing cleavage of the thrombin receptor and liberation of thrombin receptor-activating peptide. Bradykinin (1-5) significantly attenuates α-thrombin-induced platelet aggregation but not TRAP 1-6-induced platelet aggregation. Bradykinin (1-5) potently inhibits γ-thrombin (500 nM)-induced platelet aggregation with an ED50 of 183±2 pmol/min[1].

H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT Preparation Products And Raw materials
Tag:H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT(23815-89-6) Related Product Information
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