APRINDINE HCL
- CAS No.
- 33237-74-0
- Chemical Name:
- APRINDINE HCL
- Synonyms
- APRINDINE HYDROCHLORIDE;ms-5075;fiboran;aspenon;Fibocil;Amidonal;Aprindina;APRINDINE HCL;Compound 83846;APRINDINE HCL ISO 9001：2015 REACH
- CBNumber:
- CB8440044
- Molecular Formula:
- C22H31ClN2
- Molecular Weight:
- 358.95
- MDL Number:
- MFCD01698392
- MOL File:
- 33237-74-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 120-121° |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: >10mg/mL |
| form | solid |
| color | Light Brown to Brown |
| Water Solubility | H2O: >10mg/mL |
| Stability | Hygroscopic |
| InChI | InChI=1S/C22H30N2.ClH/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22;/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3;1H |
| InChIKey | KIPFVRHNAAZJOD-UHFFFAOYSA-N |
| SMILES | C1(CC2C=CC=CC=2C1)N(CCCN(CC)CC)C1C=CC=CC=1.Cl |
| FDA UNII | PB5EKT7Q2V |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| RTECS | TX7386000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
APRINDINE HCL price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A7606 | Aprindine hydrochloride ≥98% (HPLC), solid | 33237-74-0 | 10mg | $206 | 2026-04-30 | Buy |
| Sigma-Aldrich | A7606 | Aprindine hydrochloride ≥98% (HPLC), solid | 33237-74-0 | 50mg | $811 | 2026-04-30 | Buy |
| Usbiological | 162668 | Aprindine Hydrochloride ≥98% | 33237-74-0 | 50mg | $701 | 2026-06-03 | Buy |
| Axon Medchem | Axon4014 | Aprindine hydrochloride | 33237-74-0 | 10mg | $108.9 | 2026-05-19 | Buy |
| Axon Medchem | Axon4014 | Aprindine hydrochloride | 33237-74-0 | 50mg | $363 | 2026-05-19 | Buy |
APRINDINE HCL Chemical Properties, Uses, Production
Originator
Amidonal,Madaus,W. Germany,1976
Uses
Aprindine is a long-acting antiarrhythmic agent, effective when administered orally or intravenously in the treatment of ventricular arrhythmias of varying etiologies.
Definition
ChEBI: Aprindine hydrochloride is a member of indanes.
Manufacturing Process
104.6 g (0.5 mol) N-phenyl-2-aminoindane and 2.5 liters benzene are
introduced into a reaction vessel of 5 liters, under an atmosphere of nitrogen.
37 g (0.95 mol) sodium amide are added and the mixture is stirred during 3
hours at room temperature.
119.7 g (0.8 mol) of γ-chloropropyl diethylamine are then quickly added. After
agitation during 1 hour at room temperature, the reaction mixture is refluxed
and stirred under nitrogen during 21 hours. The mixture is then allowed to
cool and poured onto ice. The obtained aqueous phase is extracted by means
of 500 cm3 of benzene. The benzene extract is washed two times with 200
cm3 of water and the benzene is then evaporated.
The residue is treated with 500 cm3 of hydrochloric acid (2 N). The obtained
solution is evaporated to dryness and the oily residue is recrystallized from
ethanol. 176.9 g (yield 89.4%) of dihydrochloride of N-phenyl-Ndiethylaminopropyl-
2-aminoindane are obtained, MP 208° to 210°C.
The dihydrochloride is converted into monohydrochloride by dissolving 26.36 g
(0.066 mol) of dihydrochloride into 158 cm3 of water, adding drop by drop a
suitable amount (0.066 mol) of caustic soda (1 N), evaporating the aqueous
solution to dryness, drying by means of benzene, filtering the formed sodium
chloride (3.8 g) and crystallizing the cooled obtained benzene solution. 22.6 g
(95%) of monohydrochloride are obtained, MP 120° to 121°C.
brand name
Fibocil (Lilly).
Therapeutic Function
Antiarrhythmic
Biological Activity
Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3μ:5μ-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity.
APRINDINE HCL Preparation Products And Raw materials
APRINDINE HCL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin central pharmaceutical co., LTD. | -- | China | 17 | 60 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Boen pharm | 86 512-62572107 62962707 | China | 799 | 58 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Wuhan FengyaoTonghui Chemical Products Co., Ltd. | 027-87466105 15377573527 | 2678564200@qq.com | China | 17968 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
View Latest Price from APRINDINE HCL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | APRINDINE HCL
33237-74-0
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-04-20 | Aprindine hydrochloride
33237-74-0
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- APRINDINE HCL
33237-74-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Aprindine hydrochloride
33237-74-0
- $1520.00-2500.00
- TargetMol Chemicals Inc.
