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ChemicalBook >> CAS DataBase List >>(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid

(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid

(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid Structure
(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid structure
CAS No.
261165-05-3
Chemical Name:
(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid
Synonyms
BOC-(1S,3R)-3-Aminocyclopentanecarboxylic acid;(+)-(1S,3R)-N-Boc-b-homocycloleucine;(+)-(1S,3R)-N-Boc-β-Homocycloleucine;(+)-(1S,3R)-N-BOC-BETA-HOMOCYCLOLEUCINE;(1S,3R)-Boc-3-aminocyclopentane-1carboxylicaci;(1S,3R)-Boc-3-aminocyclopentane-1 carboxylic acid;(1R,3S)-N-BOC-1-AMINOCYCLOPENTANE-3-CARBOXYLIC ACID;(1S,3R)-3-[N-BOC-Amino]cyclopentane-carboxylic acid;(1S,3R)-(+)-3-(BOC-AMINO)CYCLOPENTANECARBOXYLIC ACID;(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid
CBNumber:
CB8441571
Molecular Formula:
C11H19NO4
Molecular Weight:
229.27
MDL Number:
MFCD01320857
MOL File:
261165-05-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:43
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(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid Properties

Melting point 35-49 °C
Boiling point 371.18°C (rough estimate)
Density 1.1482 (rough estimate)
refractive index 1.4490 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility slightly sol. in Methanol
pka 4.62±0.40(Predicted)
form Powder or Chunks
color White
optical activity [α]/D +16.0±1°, c = 1% in methanol
Major Application peptide synthesis
InChI InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-8-5-4-7(6-8)9(13)14/h7-8H,4-6H2,1-3H3,(H,12,15)(H,13,14)/t7-,8+/m0/s1
InChIKey RNJQBGXOSAQQDG-JGVFFNPUSA-N
SMILES [C@H]1(C(O)=O)CC[C@@H](NC(OC(C)(C)C)=O)C1
UNSPSC Code 12352202
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Safety Statements  22-24/25
WGK Germany  3
HazardClass  IRRITANT
HS Code  29223900
Storage Class 13 - Non Combustible Solids
NFPA 704
0
0 0

(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid price More Price(76)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B4397 (1S,3R)-3-(tert-Butoxycarbonylamino)cyclopentanecarboxylic Acid >95.0%(GC)(T) 261165-05-3 200mg $105 2024-03-01 Buy
Cayman Chemical 11406 BOC-(1S,3R)-3-Aminocyclopentanecarboxylic acid ≥95% 261165-05-3 50mg $94 2026-04-30 Buy
Usbiological 412591 (-)-(1R,3S)-N-Boc-1-Aminocyclopentane-3-carboxylic Acid 261165-05-3 50mg $319 2026-06-03 Buy
Usbiological 412591 (-)-(1R,3S)-N-Boc-1-Aminocyclopentane-3-carboxylic Acid 261165-05-3 100mg $425 2026-06-03 Buy
Usbiological 266646 (+)-(1S,3R)-N-Boc-3-aminocyclopentane carboxylic acid Asreported 261165-05-3 100mg $373 2026-06-03 Buy
Product number Packaging Price Buy
B4397 200mg $105 Buy
11406 50mg $94 Buy
412591 50mg $319 Buy
412591 100mg $425 Buy
266646 100mg $373 Buy

(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid Chemical Properties,Uses,Production

Chemical Properties

white powder or chunks

Uses

(-)-(1R,3S)-N-Boc-1-Aminocyclopentane-3-carboxylic Acid is a reagent used in the synthesis of 3-substituted aminocyclopentanes as potent NR2B subtype-sellective NMDA antagonists in the treatment of neuropathic pain and Parkinson’s.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

(+)-(1R,4S)-N-BOC-4-AMINOCYCLOPENT-2-ENECARBOXYLIC ACID

151907-80-1

(+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID

261165-05-3

The general procedure for the synthesis of (1S,3R)-3-((tert-butoxycarbonyl)amino)cyclopent-2-enecarboxylic acid using (1R,4S)-4-((tert-butoxycarbonyl)amino)cyclopent-2-enecarboxylic acid as a starting material was as follows: (1R,4S)-4-((tert-butoxycarbonyl)amino)cyclopent-2-enecarboxylic acid (230 g, 1.0 mol) prepared in step A was hydrogenated with 10% Pd/ C catalyst (5.0 g) in 500 mL of methanol and hydrogenated on a Parr shaker at 50 psi hydrogen pressure for 1 hour. Upon completion of the reaction, the catalyst was removed by filtration followed by evaporation of the filtrate to remove the solvent. The resulting residue was dissolved in dichloromethane and dried by adding anhydrous sodium sulfate. After filtration again, the filtrate was evaporated and dried under vacuum to afford (1S,3R)-3-((tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid as a light yellow solid (230 g, 99% yield). Analyzed by LC-MS, the calculated value of [M+H+] for C11H19NO4 was 230 and the measured value was 230, which was as expected.

References

[1] Patent: WO2004/76411, 2004, A2. Location in patent: Page 28
[2] Patent: WO2003/93231, 2003, A2. Location in patent: Page/Page column 56
[3] Patent: US2007/155731, 2007, A1. Location in patent: Page/Page column 27; 36
[4] Patent: WO2005/110409, 2005, A2. Location in patent: Page/Page column 30
[5] Patent: WO2005/75426, 2005, A1. Location in patent: Page/Page column 28

(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid synthesis

24424-99-5
71830-07-4
261165-05-3
Synthesis of (+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid from Di-tert-butyl dicarbonate and (1S,3R)-3-Aminocyclopentanecarboxylic acid

(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid Preparation Products And Raw materials

Raw materials

2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 3-oxo-, 1,1-dimethylethyl ester, (1R,4S)- (1S,4R)-tert-butyl 3-oxo-2-azabicyclo[2.2.1]hept-5-ene-2-carboxylate 2-Azabicyclo[2.2.1]heptan-3-one (1R,4S)-4-Aminocyclopent-2-enecarboxylic acid (1S,3R)-Methyl 3-[(tert-butoxycarbonyl)-amino]cyclopentanecarboxylate
(1S,3R)-3-Aminocyclopentanecarboxylic acid (+)-(1R,4S)-N-Boc-4-aminocyclopent-2-enecarboxylic acid Di-tert-butyl dicarbonate 2-Azabicyclo[2.2.1]hept-5-en-3-one Acetic anhydride

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Preparation Products

(-)-(1R,3S)-N-Boc-3-Aminocyclopentanecarboxylic acid methyl (1R,3R)-3-{[(tert-butoxy)carbonyl]amino}cyclopentane-1-carboxylate

(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid Suppliers

Global( 147)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai HC Biotech Co., Ltd 021-20227858 sale@hcbiotech.com.cn China 1173 55
TaiChem Taizhou Limited 052386810091 zcwy9518@yeah.net China 3917 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Supplier Advantage
Shanghai HC Biotech Co., Ltd 55
TaiChem Taizhou Limited 58
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Wuhan Chemwish Technology Co., Ltd 56
Jia Xing Isenchem Co.,Ltd 66
Nanjing Chemlin Chemical Co., Ltd 64
Chemsky（shanghai）International Co.,Ltd. 50
China DongFan Chemical Co.,LTD 66

View Lastest Price from (+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID pictures 2026-07-02 (+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID
261165-05-3
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
(+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID pictures 2019-08-02 (+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID
261165-05-3
 $1.00 1KG 95-99% 500kg/month Career Henan Chemical Co

(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid Spectrum

(+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID(261165-05-3)1HNMR(+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID(261165-05-3)1HNMR

261165-05-3((+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid)Related Search:

(-)-(1S,4R)-N-Boc-4-aminocyclopent-2-enecarboxylic acid Boc-1,3-cis-achc-OH Boc-3-aminocyclopentanecarboxylic acid (1R,2R,4S)-N-Boc-1-amino-2-hydroxycyclo-pentane-4-carboxylic acid methyl ester (1R,3R)-N-Boc-3-aminocyclopentanecarboxylic acid 95% (98% e.e.)
C(1S,2S,3R,4R)-3-(1-acetylamino-2-ethylbuyl)-4-tuboxycarbonyl-amino-2-methylcyclopentane carboxylic acid methyl ester 4-[(tert-Butoxycarbonyl)amino]bicyclo[2.1.1]hexane-1-carboxylic acid (1R,2S,4S)-N-Boc-1-amino-2-hydroxycyclopentane-4-carboxylic acid methyl ester 3-Aminocyclopentanecarboxylic acid (+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid
BOC-1-AMINOCYCLOPENTANECARBOXYLIC ACID (-)-(1R,3S)-N-Boc-3-Aminocyclopentanecarboxylic acid

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Cyclopentanecarboxylicacid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-, (1S,3R)- (+)-(1S,3R)-N-BOC-BETA-HOMOCYCLOLEUCINE (1S,3R)-(+)-3-(BOC-AMINO)CYCLOPENTANECARBOXYLIC ACID (1R,3S)-N-TERT-BUTOXYCARBONYL-1-AMINOCYCLOPENTANE-3-CARBOXYLIC ACID (-)-(1R,3S)-N-ALPHA-T-BUTOXYCARBONYL-1-AMINOCYCLOPENTANE-3-CARBOXYLIC ACID (+)-(1R,3S)-N-BOC-1-AMINOCYCLOPENTANE-3-CARBOXYLIC ACID (1R,3S)-N-BOC-1-AMINOCYCLOPENTANE-3-CARBOXYLIC ACID (1R,3S)-N-boc-1-Aminocyclopentane-3-carboxylicacid(e.e.) (1S,3R)-(+)-3-Aminocyclopentanecarboxylic acid, N-BOC protected Cis-3-(N-Tert-Butoxycarbonylamino)Cyclopentanecarboxylic Acid (+)-(1S,3R)-N-Boc-b-homocycloleucine (1R,3s)-N-Boc-1-aminocyclopentane-3-carboxylic acid, 95%, ee:98% (1R,3S)-N-BOC-1-Aminocyclopentane-3-carboxylic acid, 98% ee (1R,3S)-N-BOC-1-Aminocyclopentane-3-carboxylic acid,95%,98% ee (1R,3S)-N-BOC-1-Aminocyclopentane-3-carboxylic acid(1R,3S)-N-tert-Butoxycarbonyl-1-aminocyclopentane-3-carboxylic acid (1S,3R)-Boc-3-aminocyclopentane-1 carboxylic acid (1S,3R)-(+)-3-[(tert-Butoxycarbonyl)amino]cyclopentane-1-carboxylic acid (1S,3R)-(+)-3-Aminocyclopentane-1-carboxylic acid, N-BOC protected (+)-(1S,3R)-N-Boc-3-aMinocyclopentanecarboxylic acidacid (1S,3R)-3-((tert-Butoxycarbonyl)aMino)cyclopentanecarboxylic acid Cis(1S,3R)-3-((tert-butoxycarbonyl)aMino) cyclopentanecarboxylic acid (1S,3R)-(+)-3-(Boc-amino)cyclopentanecarboxylic acid >=96.0% (HPLC) (+)-(1S,3R)-N-(Tert-Butoxy)Carbonyl 3-Aminocyclopentanecarboxylic acid BOC-(1S,3R)-3-Aminocyclopentanecarboxylic acid (1S,3R)-3-(tert-Butoxycarbonylamino)cyclopentanecarboxylic Acid (1S,3R)-(+)-3-Aminocyclopentane-1-carboxylic acid, N-BOC protected 97% (1S,3R)-3-(tert-Butoxycarbonylamino)cyclopentanecarboxylic Acid > (1S,3R)-(+)-3-(Boc-amino)cyclopentanecarboxylicacid,95% (1S,3R)-Boc-3-aminocyclopentane-1carboxylicaci (+)-(1S,3R)-N-BOC-3-AMINOCYCLOPENTANECARBOXYLIC ACID USP/EP/BP (+)-(1S,3R)-3-[(t-Butoxycarbonyl)amino]cyclopentanecarboxylic acid (+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylicacidacid (-)-(1R,3s)-n-boc-1-aminocyclopentane-3-carboxylic acid (+)-(1S,3R)-N-Boc-β-Homocycloleucine (1S,3R)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclopentanecarboxylic acid (+)-(1S,3R)-N-Fmoc3-aminocyclopentanecarboxylicacidacid (1S,3R)-(+)-3-(Boc-amino)cyclopentanecarboxylic acid (1S,3R)-3-[N-BOC-Amino]cyclopentane-carboxylic acid (+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid (+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid 261165-05-3 Beta-Amino Acids Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives Unnatural Amino Acid Derivatives Unusual amino acids API intermediates Beta-Amino Acids Peptide Synthesis