Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>BETd-260

BETd-260

BETd-260 Structure
BETd-260 structure
CAS No.
2093388-62-4
Chemical Name:
BETd-260
Synonyms
ZBC260;BETd-260;BETd-260/ZBC260;4-[(3-Cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide;9H-Pyrimido[4,5-b]indole-2-carboxamide, 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-6-methoxy-;4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-N-{5-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]pentyl}-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide
CBNumber:
CB84667623
Molecular Formula:
C43H46N10O6
Molecular Weight:
798.89
MDL Number:
MFCD31563593
MOL File:
2093388-62-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
Request For Quotation

BETd-260 Properties

Density 1.52±0.1 g/cm3(Predicted)
storage temp. -80°C, protect from light, stored under nitrogen
solubility DMSO : 25 mg/mL (31.29 mM);Water : < 0.1 mg/mL (insoluble)
form Solid
pka 10.73±0.40(Predicted)
color Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

BETd-260 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0021622 BETd-260 ≥98% 2093388-62-4 5mg $433 2026-06-04 Buy
ChemScene CS-0021622 BETd-260 ≥98% 2093388-62-4 10mg $650 2026-06-04 Buy
ChemScene CS-0021622 BETd-260 ≥98% 2093388-62-4 25mg $1051 2026-06-04 Buy
ChemScene CS-0021622 BETd-260 ≥98% 2093388-62-4 50mg $1560 2026-06-04 Buy
ApexBio Technology BA2875 BETd-260 2093388-62-4 1mg $180 2026-05-06 Buy
Product number Packaging Price Buy
CS-0021622 5mg $433 Buy
CS-0021622 10mg $650 Buy
CS-0021622 25mg $1051 Buy
CS-0021622 50mg $1560 Buy
BA2875 1mg $180 Buy

BETd-260 Chemical Properties, Uses, Production

Description

BETd-260 is a PROTAC connected by ligands for Cereblon and BET. It potently suppresses cell viability and induces apoptosis in hepatocellular carcinomca (HCC) cells.

Uses

BETd-260 (ZBC 260) is a PROTAC connected by ligands for Cereblon and BET, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line[1]. BETd-260 potently suppresses cell viability and robustly induces apoptosis in hepatocellular carcinoma (HCC) cells[2].

in vivo

BETd-260 (5 mg/kg, i.v., every other day, thrice a week for 3 weeks) causes rapid tumor regression with a maximum of >90% regression in mice bearing RS4;11 xenograft tumors, and with no body weight loss or other signs of toxicity in mice. BETd-260 (5 mg/kg, i.v.) degrades the BRD2, BRD3, and BRD4 proteins for more than 24 h, with robust cleavage of PARP and caspase-3, and strong down-regulation of c-Myc protein in RS4;11 xenograft mice model[1].

IC 50

BRD4: <30 pM (IC50); BRD2: 30-100 pM (IC50); BRD3: 30-100 pM (IC50)

References

[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
[2] Zhang H, et al. Targeting BET Proteins With a PROTAC Molecule Elicits Potent Anticancer Activity in HCC Cells. Front Oncol. 2020;9:1471. Published 2020 Jan 14. DOI:10.3389/fonc.2019.01471

BETd-260 Preparation Products And Raw materials

Raw materials

Preparation Products

BETd-260 Suppliers

Global Suppliers ( 44)
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4865 55
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977 wj520wjxby@126.com China 1941 55
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1644 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 sales@sarms4muscle.com China 10378 58
Changzhou Chenhong Biotechnology Co., Ltd. +86-0519-85788828 +86-13775037613 sales@chemrenpharm.com China 4082 58
BOC Sciences +1-631-485-4226 inquiry@bocsci.com United States 19935 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5123 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Chuzhou KeMail Chemical Technology Co., Ltd 55
Fan De(Beijing) Biotechnology Co., Ltd. 58
Jilin Province Woda Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
Changzhou Chenhong Biotechnology Co., Ltd. 58
BOC Sciences 58
Shanghai hongqu biomedical technology co. LTD 58

View Latest Price from BETd-260 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BETd-260 pictures 2026-07-15 BETd-260
2093388-62-4
 $132.00-496.00 97.88% 10g TargetMol Chemicals Inc.
BETd-260 pictures 2026-07-15 BETd-260
2093388-62-4
 $132.00-496.00 97.88% 10g TargetMol Chemicals Inc.
  • BETd-260 pictures
  • BETd-260
    2093388-62-4
  • $132.00-496.00
  • 97.88%
  • TargetMol Chemicals Inc.
  • BETd-260 pictures
  • BETd-260
    2093388-62-4
  • $132.00-496.00
  • 97.88%
  • TargetMol Chemicals Inc.

BETd-260 Spectrum

BETd-260(2093388-62-4)1HNMR

2093388-62-4 (BETd-260) Related Search:

KT474 Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-(difluoromethyl)-1-[trans-4-[[4-[[3-[1-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-4-yl]-2-propyn-1-yl]oxy]-1-piperidinyl]methyl]cyclohexyl]-1H-pyrazol-4-yl]-5-(1R,4R)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl-, hydrochloride (1:1) dBET6 dBET1 ARV-825
1,2,3,4,5,6,7,8,9-Nonachlorodecane

1of2

BETd-260 ZBC260 9H-Pyrimido[4,5-b]indole-2-carboxamide, 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-6-methoxy- BETd-260/ZBC260 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-N-{5-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]pentyl}-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide 4-[(3-Cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]pentyl]-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide 2093388-62-4 C43H46N10O6