ChemicalBook >> CAS DataBase List >>1-(2-Chloro-pyridin-4-yl)-ethanone

1-(2-Chloro-pyridin-4-yl)-ethanone

1-(2-Chloro-pyridin-4-yl)-ethanone structure

CAS No.: 23794-15-2

Chemical Name:: 1-(2-Chloro-pyridin-4-yl)-ethanone

Synonyms: 1-(2-Chloropyridin-4-yl)ethan-1-one;4-ACETYL-2-CHLOROPYRIDINE;4-Acetyl-2-chloropyridine,97%;1-(2-Chloro-4-pyridyl)ethanone;1-(2-Chloro-4-pyridinyl)ethanone;1-(2-chloropyridine-4-yl)ethanone;1-(2-Chloro-pyridin-4-yl)-ethanone;Ethanone, 1-(2-chloro-4-pyridinyl)-;1-(2-chloro-4-pyridinyl)-1-ethanone;1-(2-Chloropyridin-4-yl)ethanone ,97%

CBNumber:: CB8478610

Molecular Formula:: C7H6ClNO

Molecular Weight:: 155.58

MDL Number:: MFCD07699406

MOL File:: 23794-15-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:55:45

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1-(2-Chloro-pyridin-4-yl)-ethanone Properties

Melting point	36.5 °C
Boiling point	270.2±25.0 °C(Predicted)
Density	1.233±0.06 g/cm3(Predicted)
Flash point	>110℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	solid
pka	-1.55±0.10(Predicted)
color	Off white to brown
InChI	1S/C7H6ClNO/c1-5(10)6-2-3-9-7(8)4-6/h2-4H,1H3
InChIKey	ZJCGPQZERFBGSM-UHFFFAOYSA-N
SMILES	CC(=O)c1ccnc(Cl)c1
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

target organs

Respiratory system

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

RIDADR

UN2811

WGK Germany

Hazard Note

Harmful

HazardClass

IRRITANT-HARMFUL

HazardClass

6.1

HS Code

2933399990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

1-(2-Chloro-pyridin-4-yl)-ethanone price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	734918	4-Acetyl-2-chloropyridine 97%	23794-15-2	1g	$119	2023-06-20	Buy
Apolloscientific	OR8761	4-Acetyl-2-chloropyridine 95%	23794-15-2	1g	$21	2026-06-04	Buy
Activate Scientific	AS22752	2-Chloro-4-acetylpyridine 97%	23794-15-2	1g	$27	2026-06-04	Buy
Activate Scientific	AS22752	2-Chloro-4-acetylpyridine 97%	23794-15-2	5g	$47	2026-06-04	Buy
Activate Scientific	AS22752	2-Chloro-4-acetylpyridine 97%	23794-15-2	25g	$158	2026-06-04	Buy

Product number	Packaging	Price	Buy
734918	1g	$119	Buy
OR8761	1g	$21	Buy
AS22752	1g	$27	Buy
AS22752	5g	$47	Buy
AS22752	25g	$158	Buy

1-(2-Chloro-pyridin-4-yl)-ethanone Chemical Properties, Uses, Production

Uses

1-(2-Chloro-4-pyridinyl)ethanone is used for the synthesis of pyrimidine derivatives as hSMG-1 inhibitors in the treatment of cancer.

Synthesis

2-Chloro-N-methoxy-N-methylisonicotinamide

250263-39-9

75-16-1

23794-15-2

Step 2: Synthesis of 1-(2-chloropyridin-4-yl)ethanone To a solution of 2-chloro-N-methoxy-N-methylisonicotinamide (10.0 g, 50 mmol) in anhydrous tetrahydrofuran (50 mL) was slowly added 3M methylmagnesium bromide solution in tetrahydrofuran (50 mL, 150 mmol) at 0 °C, keeping stirring. After addition, the reaction mixture was gradually warmed to room temperature and stirring was continued overnight. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution, followed by extraction of the organic phase with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 1-(2-chloropyridin-4-yl)ethanone (7.5 g, 96% yield). Mass spectrometric analysis (ESI) showed m/z: 156.0 [M + H]+.

References

[1] Patent: EP2952510, 2015, A1. Location in patent: Paragraph 0106
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 21, p. 6636 - 6641,6
[3] Patent: WO2016/97351, 2016, A1. Location in patent: Page/Page column 11-12
[4] Patent: WO2004/78682, 2004, A2. Location in patent: Page 17-18
[5] Patent: US2012/225876, 2012, A1. Location in patent: Page/Page column 50

1-(2-Chloro-pyridin-4-yl)-ethanone Preparation Products And Raw materials

Raw materials

Tetrahydrofuran 2-Chloro-4-cyanopyridine Methyl bromide Magnesium 2-Chloro-N-methoxy-N-methylisonicotinamide

Methylmagnesium Bromide Ammonium chloride

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Preparation Products

2-Chloro-4-(1,1-difluoroethyl)pyridine 1-(2-Chloropyridin-4-yl)ethanol

1-(2-Chloro-pyridin-4-yl)-ethanone Suppliers

Global Suppliers ( 156)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Yangzhou Siyu Chemical Co.,Ltd.	0514-87325867	sales@siyuchem.com	China	370	55
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Shangchem Co., Ltd.	+86-21-68182121		China	881	52
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Jinan Trio PharmaTech Co., Ltd.	0531-88811783	sales@trio-pharmatech.com	China	1856	62

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Yangzhou Siyu Chemical Co.,Ltd.	55
Alfa Aesar	84
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Shangchem Co., Ltd.	52
Accela ChemBio Co.,Ltd.	64
Nanjing Chemlin Chemical Co., Ltd	64
Jinan Trio PharmaTech Co., Ltd.	62

View Latest Price from 1-(2-Chloro-pyridin-4-yl)-ethanone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE 23794-15-2	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2024-09-06	4-Acetyl-2-chloropyridine 23794-15-2	$2190.00	1Kg	98	500 Kg	R&D Scientific Inc.
2019-07-10	1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE 23794-15-2	$8.80	1KG	97%-99%	100kg	Career Henan Chemical Co

1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE
23794-15-2
$1.10
99.00%
Dideu Industries Group Limited

4-Acetyl-2-chloropyridine
23794-15-2
$2190.00
98
R&D Scientific Inc.

1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE
23794-15-2
$8.80
97%-99%
Career Henan Chemical Co

1-(2-Chloro-pyridin-4-yl)-ethanone Spectrum

1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE(23794-15-2)¹HNMR

23794-15-2 (1-(2-Chloro-pyridin-4-yl)-ethanone) Related Search:

1-(3-Amino-2-chloro-pyridin-4-yl)-ethanone 1-(2-Chloro-pyridin-4-yl)-ethanone 3-Amino-2-chloro-isonicotinic acid methyl ester 4-Acetylpyridine 2-Chloro-5-acetylpyridine

2-Chloro-4-heptanoylpyridine 2-Chloro-4-octanoylpyridine 2-Chloro-4-hexanoylpyridine 2-Chloro-4-butyrylpyridine 2-Chloro-4-propionylpyridine

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1-(2-chloro-4-pyridinyl)ethanone(SALTDATA: FREE) Ethanone, 1-(2-chloro-4-pyridinyl)- 1-(2-Chloro-4-pyridinyl)ethanone 1-(2-Chloro-4-pyridyl)ethanone 4-ACETYL-2-CHLOROPYRIDINE 1-(2-chloro-4-pyridinyl)-1-ethanone 1-(2-chloropyridine-4-yl)ethanone 1-(2-Chloropyridin-4-yl)ethanone ,97% 4-Acetyl-2-chloropyridine,97% 1-(2-CHLORO-PYRIDIN-4-YL)-ETHANONE ISO 9001：2015 REACH 1-(2-Chloropyridin-4-yl)ethan-1-one 1-(2-Chloro-pyridin-4-yl)-ethanone 23794-15-2 Pyridines Pyridine series