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HEMICHOLINIUM-3

HEMICHOLINIUM-3 structure

CAS No.: 312-45-8

Chemical Name:: HEMICHOLINIUM-3

Synonyms: hc-3;Dibromide;hemicholine;hemicholiniumbromide;hemicholinium-3bromide;hemicholiniumdibromide;hemicholinium-3dibromide;Hemicholinium 3, 10 mM in DMSO;2,2'-(4,4'-biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium) dibromide;2,2’-(4,4’-biphenylylene)bis(2-hydroxy-4,4-dimethyl-morpholiniudibromide

CBNumber:: CB8497048

Molecular Formula:: C24H34N2O4.2Br

Molecular Weight:: 574.351

MDL Number:: MFCD00011978

MOL File:: 312-45-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-22 18:57:36

Product description	Number	Pack Size	Price
Hemicholinium-3 solid, ≥95% (HPLC)	H108	100mg	$104
Hemicholinium-3 solid, ≥95% (HPLC)	H108	500mg	$425
Hemicholinium-3	H245658	10mg	$80
HEMICHOLINIUM-3 95.00%	INB0004498	100MG	$597.77
HEMICHOLINIUM-3 95.00%	INB0004498	500MG	$725.22

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HEMICHOLINIUM-3 Properties

Melting point	180°; mp 226- 228° (dec)
storage temp.	Store at -20°C
solubility	ethanol: 1.3 mg/mL
form	solid
color	white
Water Solubility	Water : 33.33 mg/mL (58.03 mM; Need ultrasonic)
Merck	13,4660
BRN	5704458
InChI	1S/C24H34N2O4.2BrH/c1-25(2)13-15-29-23(27,17-25)21-9-5-19(6-10-21)20-7-11-22(12-8-20)24(28)18-26(3,4)14-16-30-24;;/h5-12,27-28H,13-18H2,1-4H3;2*1H/q+2;;/p-2
InChIKey	OPYKHUMNFAMIBL-UHFFFAOYSA-L
SMILES	[Br-].[Br-].C[N+]1(C)CCOC(O)(C1)c2ccc(cc2)-c3ccc(cc3)C4(O)C[N+](C)(C)CCO4
FDA UNII	65NY3I7ZD0
EPA Substance Registry System	Morpholinium, 2,2'-[1,1'-biphenyl]-4,4'-diylbis[2-hydroxy-4,4-dimethyl-, dibromide (312-45-8)
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301+H311+H331-H315-H319-H335
Precautionary statements	P261-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338
target organs	Respiratory system
PPE	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes	T
Risk Statements	23/24/25-36/37/38
Safety Statements	26-36/37/39-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	QF2450000
TSCA	TSCA listed
HazardClass	6.1(b)
PackingGroup	III
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3
Toxicity	LD50 i.p. in female mice: 0.048-0.082 mg/kg (DiAugustine, Haarstad)

HEMICHOLINIUM-3 price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H108	Hemicholinium-3 solid, ≥95% (HPLC)	312-45-8	100mg	$104	2026-04-30	Buy
Sigma-Aldrich	H108	Hemicholinium-3 solid, ≥95% (HPLC)	312-45-8	500mg	$425	2026-04-30	Buy
TRC	H245658	Hemicholinium-3	312-45-8	10mg	$80	2021-12-16	Buy
American Custom Chemicals Corporation	INB0004498	HEMICHOLINIUM-3 95.00%	312-45-8	100MG	$597.77	2021-12-16	Buy
American Custom Chemicals Corporation	INB0004498	HEMICHOLINIUM-3 95.00%	312-45-8	500MG	$725.22	2021-12-16	Buy

Product number	Packaging	Price	Buy
H108	100mg	$104	Buy
H108	500mg	$425	Buy
H245658	10mg	$80	Buy
INB0004498	100MG	$597.77	Buy
INB0004498	500MG	$725.22	Buy

HEMICHOLINIUM-3 Chemical Properties,Uses,Production

Uses

Acetylcholine stores depletor

Uses

Research tool as cholinergic probe, to deplete acetylcholine stores.

Uses

Hemicholinium-3 has been used in the preparation of Krebs-HC-3 buffer to study its effects on choline uptake and choline acetyltransferase activity in differentiated human neuroblastoma (SK-N-SH) cells.

Biochem/physiol Actions

Hemicholinium-3 plays a role in blocking the neuronal choline uptake thereby inhibiting acetylcholine synthesis in the brain.

in vivo

Hemicholinium-3 impairs spatial learning. Hemicholinium-3 (2.5, 5.0 μg/rat/ICV; 1 h before training) dose dependently impairs spatial learning^[5].

HEMICHOLINIUM-3 Preparation Products And Raw materials

Raw materials

Preparation Products

HEMICHOLINIUM-3 Suppliers

Global( 39)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53802	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	26718	65
Shanghai Macklin Biochemical Co.,Ltd.	15221275939; 15221275939	shenlinxing@macklin.cn	China	15781	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9803	58
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	89689	60
Shanghai Chaolan Chemical Technology Center	021-QQ：65489617 15618227136	Sales@ATKchemical.com	China	9550	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
HANGZHOU LEAP CHEM CO., LTD.	58
Aladdin Scientific	58
DAYANG CHEM (HANGZHOU) CO.,LTD	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
Shanghai Macklin Biochemical Co.,Ltd.	55
Sigma-Aldrich	80
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
Shanghai Chaolan Chemical Technology Center	58

View Lastest Price from HEMICHOLINIUM-3 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-22	Hemicholinium 3 312-45-8	US $41.00-148.00 / mg		99.95%	10g	TargetMol Chemicals Inc.

Hemicholinium 3
312-45-8
US $41.00-148.00 / mg
99.95%
TargetMol Chemicals Inc.

HEMICHOLINIUM-3 Spectrum

HEMICHOLINIUM-3(312-45-8)¹HNMR HEMICHOLINIUM-3(312-45-8)¹³CNMR HEMICHOLINIUM-3(312-45-8)IR1 HEMICHOLINIUM-3(312-45-8)IR2 HEMICHOLINIUM-3(312-45-8)Raman

312-45-8(HEMICHOLINIUM-3)Related Search:

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4,4'-Dimethylbiphenyl 4-Methylphenethylamine 1-(4-Methylphenyl)ethanol DL-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL N-Methyldiethanolamine

2-(BENZYLOXY)-ETHYLAMINE 4,4'-Bis(methoxymethyl)-1,1'-biphenyl 1-(4-BIPHENYLYL)ETHANOL CHOLINE BROMIDE N,N-Dimethylphenethylamine

BIPHENYLENE 4,4'-DIETHYLBIPHENYL 2-PHENYLMORPHOLINE

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2,2’-(1,1’-biphenyl)-4,4’-diylbis(2-hydroxy-4,4-dimethyl-morpholinium)dibrom 2,2’-(4,4’-biphenylylene)bis(2-hydroxy-4,4-dimethyl-morpholiniudibromide hc-3 hemicholine hemicholinium-3bromide hemicholinium-3dibromide hemicholiniumbromide hemicholiniumdibromide 2,2'-(4,4'-biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium) dibromide 2-[4-[4-(2-hydroxy-4,4-dimethyl-morpholin-4-ium-2-yl)phenyl]phenyl]-4,4-dimethyl-morpholin-4-ium-2-ol dibromide 2-[4-[4-(2-hydroxy-4,4-dimethylmorpholin-4-ium-2-yl)phenyl]phenyl]-4,4-dimethylmorpholin-4-ium-2-ol dibromide Dibromide HACU,Choline,receptor,system,Hemicholinium dibromide,Inhibitor,transporter,ACh,Nicotinic,Hemicholinium 3,Hemicholinium3,inhibit,nervous,Enteric,neuromuscular,acetylcholine,Cholinesterase (ChE) 2,2'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-hydroxy-4,4-dimethylmorpholin-4-ium) bromide Hemicholinium 3, 10 mM in DMSO 2,2'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-hydroxy-4,4-dimethylmorpholin-4-ium) bromide 312-45-8 C24H34N2O42Br Br2C24H34N2O4 C24H34Br2N2O4