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N-Methyldiethanolamine

CAS No.
105-59-9
Chemical Name:
N-Methyldiethanolamine
Synonyms
MDEA;METHYL DIETHANOLAMINE;Methyldiethanolamin;Methyliminodiethanol;N-Methyldiethanolamin;2-[2-hydroxyethyl(methyl)amino]ethanol;FC MDEA;usafdo-52;USAF DO-52;Mdea (diol)
CBNumber:
CB3260193
Molecular Formula:
C5H13NO2
Molecular Weight:
119.16
MDL Number:
MFCD00002848
MOL File:
105-59-9.mol
MSDS File:
SDS
Last updated:2026-08-06 08:00:44
Product description Number Pack Size Price
N-Methyl-2,2′-iminodiethanol for synthesis 8.05851 100ML $37.7
N-Methyl-2,2′-iminodiethanol for synthesis 8.05851 1L $75.4
N-Methyldiethanolamine ≥99% 471828 2l $101
N-Methyldiethanolamine ≥99% 471828 18l $582
N-Methyldiethanolamine TRC-M301625-10ML 10mL $65
More product size

N-Methyldiethanolamine Properties

Melting point -21 °C
Boiling point 246-248 °C(lit.)
Density 1.038 g/mL at 25 °C(lit.)
vapor density 4 (vs air)
vapor pressure 0.01 mm Hg ( 20 °C)
refractive index n20/D 1.469(lit.)
Flash point 260 °F
storage temp. Store below +30°C.
solubility Chloroform (Slightly), Methanol (Slightly)
form Liquid
pka 14.41±0.10(Predicted)
color Clear colorless to light yellow
Odor Ammonical
PH Range 11.5 at 100 g/l at 20 °C
PH 11.5 (100g/l, H2O, 20℃)
explosive limit 0.9-8.4%(V)
Viscosity 99.05mm2/s
Water Solubility MISCIBLE
BRN 1734441
Henry's Law Constant 3.3×103 mol/(m3Pa) at 25℃, Du et al. (2017)
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions FILM FORMING
InChI 1S/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3
InChIKey CRVGTESFCCXCTH-UHFFFAOYSA-N
SMILES N(CCO)(CCO)C
LogP -1.16 at 23℃
Surface tension 33.5 mN/m at 303.15K
Indirect Additives used in Food Contact Substances N-METHYLDIETHANOLAMINE
FDA 21 CFR 175.105; 176.170
CAS DataBase Reference 105-59-9(CAS DataBase Reference)
FDA UNII 3IG3K131QJ
NIST Chemistry Reference Methyldiethanolamine(105-59-9)
EPA Substance Registry System N-Methyldiethanolamine (105-59-9)
UNSPSC Code 12352104
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
Hazard Codes  Xi
Risk Statements  36
Safety Statements  24
RIDADR  2735
WGK Germany  1
RTECS  KL7525000
Autoignition Temperature 770 °F
TSCA  TSCA listed
HS Code  2922 17 00
HazardClass  8
PackingGroup  II
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Hazardous Substances Data 105-59-9(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 4680 mg/kg
REACH Registrations Active
NFPA 704
1
1 0

N-Methyldiethanolamine price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.05851 N-Methyl-2,2′-iminodiethanol for synthesis 105-59-9 100ML $37.7 2026-04-30 Buy
Sigma-Aldrich 8.05851 N-Methyl-2,2′-iminodiethanol for synthesis 105-59-9 1L $75.4 2026-04-30 Buy
Sigma-Aldrich 471828 N-Methyldiethanolamine ≥99% 105-59-9 2l $101 2026-04-30 Buy
Sigma-Aldrich 471828 N-Methyldiethanolamine ≥99% 105-59-9 18l $582 2026-04-30 Buy
TRC TRC-M301625-10ML N-Methyldiethanolamine 105-59-9 10mL $65 2026-06-03 Buy
Product number Packaging Price Buy
8.05851 100ML $37.7 Buy
8.05851 1L $75.4 Buy
471828 2l $101 Buy
471828 18l $582 Buy
TRC-M301625-10ML 10mL $65 Buy

N-Methyldiethanolamine Chemical Properties,Uses,Production

Chemical Properties

N-Methyldiethanolamine (MDEA) is a colorless to yellow viscous liquid with an ammonia-like odor. It is completely soluble in water. N-Methyldiethanolamine is an alkyl alkanolamine.It combines the chemical characteristics of both amines and alcohols so that it is capable of undergoing reactions typical of both alcohols and amines: forming quaternary amine salts, soaps, and esters.

Uses

N-methyldiethanolamine is used as an intermediate in the synthesis of numerous products. Its unique chemistry has resulted in its use in diverse areas, including coatings, textile lubricants, polishes, detergents, pesticides, personal-care products, pharmaceuticals, urethane catalysts, and water-treatment chemicals. It is also used in absorption of acidic gases, catalyst for polyurethane foams, pH control agent.

Uses

N-Methyldiethanolamine is a reagent used for protection of boronic acids as N-methyl-O,O-diethanolamine esters.

Preparation

N-methyldiethanolamine is produced by the reaction between ethylene oxide and methylamine.
Preparation of N-methyldiethanolamine

Synthesis Reference(s)

Journal of the American Chemical Society, 107, p. 6659, 1985 DOI: 10.1021/ja00309a039

General Description

Colorless liquid.

Air & Water Reactions

Very water soluble .

Reactivity Profile

N-Methyldiethanolamine is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. N-Methyldiethanolamine may react with oxidizing materials.

Health Hazard

Exposure can cause irritation of eyes, nose and throat.

Fire Hazard

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as nitrogen oxides and carbon monoxide, may be formed when involved in fire.

Flammability and Explosibility

Non flammable

Environmental Fate

N-methyldiethanolamine is readily biodegradable, and its bioconcentration potential is low. Releases to the environment would not persist and would degrade rapidly. The potential for mobility in soil is very high. It is slightly toxic to aquatic organisms on an acute basis.

storage

N-methyldiethanolamine is stable under normal storage and use conditions, but elevated temperatures can cause it to decompose. Decomposition products depend upon temperature, air supply, and the presence of other materials. Avoid contact with nitrites, strong acids, and strong oxidizers. Avoid unintended contact with halogenated hydrocarbons. N-methyldiethanolamine can react with halogenated organics, resulting in temperature and/or pressure increases. It is corrosive when wet. Heating above 60°C (140°F) in the presence of aluminum can result in corrosion and generation of flammable hydrogen gas.

Toxics Screening Level

The updated initial threshold screening level (ITSL) for methyldiethanolamine is 6 μg/m3 based on an annual averaging time.

N-Methyldiethanolamine Preparation Products And Raw materials

Global( 482)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd
+86-17392712779 1097@dideu.com China 3989 58
Qingdao RENAS Polymer Material Co., Ltd.
+86-0532-86867058 +86-18562606086 sales@qdrenas.com China 1066 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2984 55
SHANDONG ZHI SHANG CHEMICAL CO.LTD
0531-68652808 18953170293 sales@sdzschem.com China 2921 58
Lotusland Life Sciences
+8615821988213 info@longyupharma.com China 2411 58
CONIER CHEM AND PHARMA LIMITED
sales@conier.com China 49906 58
career henan chemical co
+86-0371-86658258 factory@coreychem.com China 29780 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +86-189 4982 3763 sales@tnjchem.com China 34526 58
Zhuoer Chemical Co., Ltd
02120970332; sales@zhuoerchem.com China 2901 58
Guangzhou TongYi biochemistry technology Co.,LTD
tongyibiochem@163.com China 2988 58

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