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3-O-Ethyl-L-ascorbic acid

3-O-Ethyl-L-ascorbic acid structure

CAS No.: 86404-04-8

Chemical Name:: 3-O-Ethyl-L-ascorbic acid

Synonyms: ETHYL ASCORBIC ACID;VCE;vitaMin C ethyl ether;3-O-Ethyl Ascorbyl Ether;3-0-Ethyl Ascorbic acid;VC ethyl ether;Ethyl ascorbyl ether;C8H12O6;ETHYL ASCORBIC;Ethyl Vitamin C

CBNumber:: CB8511566

Molecular Formula:: C8H12O6

Molecular Weight:: 204.18

MDL Number:: MFCD09261382

MOL File:: 86404-04-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-10 14:34:02

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3-O-Ethyl-L-ascorbic acid Properties

Melting point	112.0 to 116.0 °C
Boiling point	551.5±50.0 °C(Predicted)
Density	1.46±0.1 g/cm3(Predicted)
vapor pressure	0-0Pa at 20-25℃
storage temp.	Sealed in dry,2-8°C
solubility	Methanol (Slightly), Water (Slightly)
form	Solid
pka	8.89±0.40(Predicted)
color	White to Off-White
optical activity	46.1°(C=0.01 g/mL, MeOH, 20°C, 589nm)
Cosmetics Ingredients Functions	SKIN CONDITIONING
InChI	InChI=1S/C8H12O6/c1-2-13-7-5(11)8(12)14-6(7)4(10)3-9/h4,6,9-11H,2-3H2,1H3/t4-,6+/m0/s1
InChIKey	ZGSCRDSBTNQPMS-UJURSFKZSA-N
SMILES	O(CC)C1=C(O)C(=O)O[C@@H]1[C@H](CO)O
LogP	-0.8--0.64 at 20-25℃ and pH7
Surface tension	69-72.4mN/m at 1g/L and 20℃
EWG's Food Scores	1
FDA UNII	6MW60CB71P
UNSPSC Code	12352205
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H332-H335

Precautionary statements

P261-P280-P305+P351+P338

WGK Germany

WGK 3

HS Code

2936.27.0000

Storage Class

11 - Combustible Solids

REACH Registrations

Active

NFPA 704

	0
2		0

3-O-Ethyl-L-ascorbic acid price More Price(79)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	CDS009203	3-o-Ethyl-L-ascorbic acid Aldrich^CPR	86404-04-8	100 mg	$121	2026-04-30	Buy
TCI Chemical	E0926	3-O-Ethyl-L-ascorbic Acid >98.0%(HPLC)(T)	86404-04-8	5g	$38	2026-04-30	Buy
TCI Chemical	E0926	3-O-Ethyl-L-ascorbic Acid >98.0%(HPLC)(T)	86404-04-8	25g	$130	2026-04-30	Buy
Cayman Chemical	34139	3-O-ethyl-L-Ascorbic Acid ≥98%	86404-04-8	5g	$44	2026-04-30	Buy
Cayman Chemical	34139	3-O-ethyl-L-Ascorbic Acid ≥98%	86404-04-8	10g	$80	2026-04-30	Buy

Product number	Packaging	Price	Buy
CDS009203	100 mg	$121	Buy
E0926	5g	$38	Buy
E0926	25g	$130	Buy
34139	5g	$44	Buy
34139	10g	$80	Buy

3-O-Ethyl-L-ascorbic acid Chemical Properties, Uses, Production

Description

3-O-Ethyl-L-ascorbic acid is a product of ascorbic acid-3-O-ethylation. It has a simple molecular structure and is easily absorbed by the skin. After entering the dermis through the stratum corneum of the skin, it is easily decomposed by the biological enzymes in the human body. The effect of ascorbic acid effectively solves the fat solubility problem of ascorbic acid, and is widely used in cosmetics as a whitening agent and antioxidant.

Uses

3-O-Ethyl-L-ascorbic Acid could be a useful stabilizing agent for a para-hydroxyacetophenone solution. It could be a useful stabilizing agent for a para-hydroxyacetophenone solution.

Definition

ChEBI: 3-O-ethyl-l-ascorbic acid (EA) is a butenolide. It is an l-ascorbic acid derivative with an ethyl group at the third carbon position.

Health effects

3-O-ethyl-L-ascorbic acid improves the molecules' stability and its transportation efficacy to the skin, being absorbed faster and better. Additionally, it is less irritating to the skin. Cosmetic case studies demonstrate that they have skin brightening, collagen stimulating, and antioxidant properties.

Mechanism of action

VC ethyl ether penetrates the stratum corneum to reach the melanocytes in the basal layer, inhibits tyrosinase activity, inhibits the formation of melanin, and restores melanin to colorless, thereby effectively whitening the skin. And Chemicalbook and VC ethyl ether can directly participate in the synthesis of collagen and repair skin cell activity after entering the dermis, increasing collagen, so that the skin becomes full and elastic, making the skin delicate and smooth.

Synthesis

Synthesis_86404-04-8
The above 3-O-ethyl-5,6-O-isopropylideneascorbic acid 40g dissolved in 200ml of ethanol. 10g of cation-exchange resin was added and was refluxed for 2 hours. The catalyst was removed by an ion exchange resin and concentrated under reduced pressure. After drying, with ethyl acetate: hexane (3: 1) crystallization. After drying, obtained 33.3g 3-O-ethylascorbic acid, yield 94%. It was recrystallized in 100mL ethyl acetate giving 30.6g, yield 87%, mp: 112-114C.

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 9, p. 1618 - 1623
[2] Patent: CN105367524, 2016, A. Location in patent: Paragraph 0035; 0038
[3] Patent: WO2008/44809, 2008, A1. Location in patent: Page/Page column 10
[4] Patent: US2010/56809, 2010, A1. Location in patent: Page/Page column 3
[5] Patent: WO2008/44809, 2008, A1. Location in patent: Page/Page column 10-11

3-O-Ethyl-L-ascorbic acid synthesis

Synthesis of 3-O-Ethyl-L-ascorbic acid from L-Ascorbic acid, 3-O-ethyl-5,6-O-(1-methylethylidene)-

3-O-Ethyl-L-ascorbic acid Preparation Products And Raw materials

Raw materials

L-Ascorbic acid, 3-O-ethyl-5,6-O-(1-methylethylidene)- Bromoethane Ascorbic Acid D-erythro-Hex-2-enonic acid, γ-lactone, sodium salt (1:2) Ethanol

CationExchangeResin

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Preparation Products

3-O-Ethyl-L-ascorbic acid Suppliers

Global Suppliers ( 795)

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Jiate Catalytic Materials Co., Ltd	13953312886	370667338@qq.com	China	1	58
Beri Pharma Co., Ltd.	13427714006	sales@zhberi.com	China	19	58
Shandong Lierbang New Material Co. LTD	15553337722 13964392203	1135818881@qq.com	China	49	58
Shanghai CoachChem Co., Ltd.	+86-21-67299971；+86-21-67290723 18117322963	marketing@coachchem.com	China	96	62
Xi'an Kono chem co., Ltd.	029-84385017-8006 15891391030	info@konochemical.com	China	642	58
TINAMEN	15607209205	tianmenzhengyi@qq.com	China	12	58
Lihe Biotechnology (Shandong) Co., Ltd	13176691201 15588824841	lhswsd@126.com	China	32	58
Jinan Yunding Biotechnology Co., Ltd	15662712965	1013429786@qq.com	China	31	58
Hubei Yushenghe Biotechnology Co, Ltd	13307209205	13307209205@163.cn	China	15	58
Hangzhou Invertin Biopharm Co.,Ltd	18957272103 18957272103	chenxiaoman@hz-invertin.cn	China	86	58

Supplier	Advantage
Shandong Jiate Catalytic Materials Co., Ltd	58
Beri Pharma Co., Ltd.	58
Shandong Lierbang New Material Co. LTD	58
Shanghai CoachChem Co., Ltd.	62
Xi'an Kono chem co., Ltd.	58
TINAMEN	58
Lihe Biotechnology (Shandong) Co., Ltd	58
Jinan Yunding Biotechnology Co., Ltd	58
Hubei Yushenghe Biotechnology Co, Ltd	58
Hangzhou Invertin Biopharm Co.,Ltd	58

3-O-Ethyl-L-ascorbic acid: Benefits and Side effects
3-O-Ethyl-L-ascorbic acid is a water-soluble antioxidant that has been used in personal care formulations for many years.
Dec 13,2023

Application of 3-O-ethyl-L-ascorbic acid
3-O-ethyl-l-ascorbic acid (EA) is an l-ascorbic acid derivative with an ethyl group at the third carbon position.
Jun 15,2022

View Latest Price from 3-O-Ethyl-L-ascorbic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	3-O-Ethyl-L-ascorbic acid 86404-04-8		1kg	99.99%	1kg/5kg25kg	HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD
2026-09-15	3-O-Ethyl Ascorbic Acid 86404-04-8	$1.00	300g	99.8%	20 TONS	.GZ HONESTCHEM CO.,LTD
2026-09-15	3-O-Ethyl-L-ascorbic acid 86404-04-8	$10.00	1ASSAYS	99%	10 ton	RongNa Biotechnology Co.,Ltd

3-O-Ethyl-L-ascorbic acid
86404-04-8
$0.00
99.99%
HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD

3-O-Ethyl Ascorbic Acid
86404-04-8
$1.00
99.8%
.GZ HONESTCHEM CO.,LTD

3-O-Ethyl-L-ascorbic acid
86404-04-8
$10.00
99%
RongNa Biotechnology Co.,Ltd

3-O-Ethyl-L-ascorbic acid Spectrum

3-O-Ethyl-L-ascorbic acid(86404-04-8)¹HNMR

86404-04-8 (3-O-Ethyl-L-ascorbic acid) Related Search:

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1-Hydroxyethylidene-1,1-diphosphonic acid Ethoxyquin Ethyl acetate acetic acid, triethoxy-, ethyl ester Ascorbic Acid

Ethanol Chlorophosphonazo III Diethyl sulfide

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3-O-Ethyl-L-ascorbic Acid 3-o-ethyl-l-ascorbic acid (5R,1'S)-5-(1,2-Dihydroxy-ethyl)-4-ethoxy-3-hydroxy-5H-furan-2-one (5r)-5-[(1s)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxy-5h-furan-2-one (R)-5-((S)-1,2-dihydroxyethyl)-4-ethoxy-3-hydroxyfuran-2(5H)-one (5R)-5-(1,2-dihydroxyethyl)-4-ethoxy-3-hydroxy-2,5-dihydrofuran-2-one (5R)-5-[(1S)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxyfuran-2(5H)-one (non-preferred naMe) (5R,1'S)-5-(1,2-Dihydroxy-ethyl)-4-e 3-O-Ethyl-L-ascorbic acid VC ethyl ether Nano Liposomal 3-o-ETHYL ASCORBICACID 3-O-Ethyl-L-ascorbic Only VCE 3-O-Ethyl-Lascorbicaci 3-O-Ethyl-L-ascorbic Acid, >=99% 3-O-Ethylascorbate LGB-VCE 3-o-EthyL 3-O-Ethyl-L-ascorbicAcid> L-Ascorbic acid, 3-O-ethyl- 3-O-ethyl-l-ascorbic acid?(EA) 3-o-ETHHYL ASCORBIC ACID Skin Whitening VCE 3-O-Ethyl-L-ascorbic acid USP/EP/BP 3-O-Ethyl-L-ascorbic acid cas 86404-04-8 High Quality 3-O-Ethyl-L-Ascorbic Acid API with CAS: 86404-04-8 3-0-Ethyl-L-ascorbic acid Ethyl Ascorbic Acid (VCE) Ethyl VC 3-O-Ethyl-L-ascorbic acid(VCE) Ethyl Ascorbic Acid Powder Ethyl Ascorbic Acid 3-O-Ethyl ascorbic acid ether Vitamin C Impurity 32 3-O-Ethyl Ascorbyl Ether|Ethyl Ascorbic Acid (5R)-5-[(1S)-1,2-Dihydroxyethyl]-4-ethoxy-3-hydroxyfuran-2(5H)-one Ethyl ether of vitamin C 3-o-Ethyl-L-ascorbic acid 3-O-Ethyl-L-ascorbic acid VC Ethyl ascorbic acid 99% 3-O-Ethyl Ascorbic Acid Ether VCE ( 3-O-Ethyl-L-ascorbic acid ) 3-O-Ethyl-L-ascorbic acid (Standard) 3-0-Ethyl Ascorbic acid 3-O-ETHYLASCORBICACID 3-O-Ethyl vitaMin C ester 3-O-Ethyl Ascorbyl Ether C8H12O6 ETHYL ASCORBIC Ethyl Vitamin C Ethyl ascorbate ether ETHYL ASCORBIC ACID Ethyl ascorbyl ether VC ethyl ether vitaMin C ethyl ether VCE Ascorbyl Ethyl Ether Dipalmitate Ethyl ascorbic acid (3-O-Ethyl-L-ascorbic acid) Ethyl Ascorbic Acid (VC Ethyl Ether) (2R)-2-[(1S)-1,2-dihydroxyethyl]-3-ethoxy-4-hydroxy-2H-furan-5-one