FMF-04-159-2
- CAS No.
- 2364489-81-4
- Chemical Name:
- FMF-04-159-2
- Synonyms
- FMF-04-159-2;FMF041592,FMF 04 159 2;1H-Pyrazole-3-carboxamide, N-[1-[[3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]phenyl]sulfonyl]-4-piperidinyl]-4-[(2,4,6-trichlorobenzoyl)amino]-
- CBNumber:
- CB85540356
- Molecular Formula:
- C28H30Cl3N7O5S
- Molecular Weight:
- 683.01
- MDL Number:
- MFCD32182619
- MOL File:
- 2364489-81-4.mol
| Product description | Number | Pack Size | Price |
| FMF-04-159-2 ≥98% (HPLC) | SML3027 | 5 mg | $95.95 |
| FMF-04-159-2 ≥98% (HPLC) | SML3027 | 25 mg | $407 |
| FMF-04-159-2 ≥98%(HPLC) | 7158 | 10 | $249 |
| FMF-04-159-2 >98% | orb611957 | 10mg | $690.2 |
| FMF-04-159-2 99.34% | CS-0093104 | 25mg | $990 |
| Density | 1.53±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO: 250 mg/mL (366.03 mM) |
| pka | 10.39±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | HZPYSAHDRSBARR-QPJJXVBHSA-N |
| SMILES | O=C(C1=NNC=C1NC(C2=C(Cl)C=C(Cl)C=C2Cl)=O)NC3CCN(S(=O)(C4=CC=CC(NC(/C=C/CN(C)C)=O)=C4)=O)CC3 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
FMF-04-159-2 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3027 | FMF-04-159-2 ≥98% (HPLC) | 2364489-81-4 | 5 mg | $95.95 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML3027 | FMF-04-159-2 ≥98% (HPLC) | 2364489-81-4 | 25 mg | $407 | 2025-07-31 | Buy |
| Tocris | 7158 | FMF-04-159-2 ≥98%(HPLC) | 2364489-81-4 | 10 | $249 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611957 | FMF-04-159-2 >98% | 2364489-81-4 | 10mg | $690.2 | 2021-12-16 | Buy |
| ChemScene | CS-0093104 | FMF-04-159-2 99.34% | 2364489-81-4 | 25mg | $990 | 2021-12-16 | Buy |
FMF-04-159-2 Chemical Properties,Uses,Production
Uses
FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively[1].
Biological Activity
FMF-04-159-2 is a specific and potent covalent inhibitor Cyclin-dependent kinase 14 (CDK14) in cells th at targets CDK14 at C218. FMF-04-159-2 reversibly inhibits CDK2, CDK10, and other TAIRE kinases (CDK15, CDK16, CDK17, and CDK18) with comparable potency to each other. It exhibits mild antiproliferative effects.
IC 50
CDK14/Cyclin Y: 39.6 nM (IC50, in NanoBRET assay); CDK2: 256 nM (IC50, in NanoBRET assay)
storage
Store at -20°C
References
[1] Ferguson FM, et al. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019 Mar 11. pii: S2451-9456(19)30070-4. DOI:10.1016/j.chembiol.2019.02.015
FMF-04-159-2 Preparation Products And Raw materials
Raw materials
Preparation Products
FMF-04-159-2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13913916777; | info@chemlin.com.cn | China | 15724 | 64 |
| Guangzhou Zhiya Chemdrugs Co.,Ltd | 18122150900 | sculk28@163.com | China | 646 | 55 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2495 | 55 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4023 | 58 |
