XIAP (D2Z8W) Rabbit mAb
- CAS No.
- Chemical Name:
- XIAP (D2Z8W) Rabbit mAb
- Synonyms
- XIAP (D2Z8W) Rabbit mAb
- CBNumber:
- CB85705221
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
XIAP (D2Z8W) Rabbit mAb Chemical Properties,Uses,Production
Source
Rabbit
Reactivity
Human;Monkey
Background
The inhibitor of apoptosis protein family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR domain. Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression. In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9. In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase.
References
[1] Deveraux, Q.L. and Reed, J.C. (1999) Genes Dev 13, 239-52.
[2] Deveraux, Q.L. et al. (1998) EMBO J 17, 2215-23.
[3] Altieri, D.C. et al. (1999) Lab Invest 79, 1327-33.
[4] Tamm, I. et al. (2000) Clin Cancer Res 6, 1796-803.
[5] Kasof, G.M. and Gomes, B.C. (2001) J Biol Chem 276, 3238-46.
[6] Deveraux, Q.L. et al. (1997) Nature 388, 300-4.
XIAP (D2Z8W) Rabbit mAb Preparation Products And Raw materials
Raw materials
Preparation Products
XIAP (D2Z8W) Rabbit mAb Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Universal Biotech Co.,Ltd | 58 |
