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2,4-Difluoro-5-nitrobenzonitrile

2,4-Difluoro-5-nitrobenzonitrile Structure
2,4-Difluoro-5-nitrobenzonitrile structure
CAS No.
67152-20-9
Chemical Name:
2,4-Difluoro-5-nitrobenzonitrile
Synonyms
2,4-Difluoro-5-ntirobenzonitrile;5-Cyano-2,4-difluoronitrobenzene;2,4-Difluoro-5-nitrobenzonitrile;2,4-difluoro-5-nitrobenzene nitrile;Benzonitrile, 2,4-difluoro-5-nitro-
CBNumber:
CB8665841
Molecular Formula:
C7H2F2N2O2
Molecular Weight:
184.1
MDL Number:
MFCD07772030
MOL File:
67152-20-9.mol
MSDS File:
SDS
Last updated:2026-09-12 18:55:49
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2,4-Difluoro-5-nitrobenzonitrile Properties

Boiling point 271.5±40.0 °C(Predicted)
Density 1.51±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
Appearance Off-white to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Hazard Codes  Xi
Hazard Note  Irritant
HS Code  2926907090

2,4-Difluoro-5-nitrobenzonitrile price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 273206 2,4-Difluoro-5-nitrobenzonitrile Asreported 67152-20-9 1g $345 2026-06-03 Buy
Usbiological 273206 2,4-Difluoro-5-nitrobenzonitrile Asreported 67152-20-9 2g $468 2026-06-03 Buy
Usbiological 273206 2,4-Difluoro-5-nitrobenzonitrile Asreported 67152-20-9 5g $649 2026-06-03 Buy
Usbiological 273206 2,4-Difluoro-5-nitrobenzonitrile Asreported 67152-20-9 10g $832 2026-06-03 Buy
Usbiological 273206 2,4-Difluoro-5-nitrobenzonitrile Asreported 67152-20-9 25g $1274 2026-06-03 Buy
Product number Packaging Price Buy
273206 1g $345 Buy
273206 2g $468 Buy
273206 5g $649 Buy
273206 10g $832 Buy
273206 25g $1274 Buy

2,4-Difluoro-5-nitrobenzonitrile Chemical Properties,Uses,Production

Chemical Properties

white powder

Uses

2,4-Difluoro-5-nitrobenzonitrile is used in the synthesis of potent and selective tankyrase inhbitors used in the inhibition of tumorigenesis.

Synthesis

2,4-Difluorobenzonitrile

3939-09-1

2,4-DIFLUORO-5-NITROBENZONITRILE

67152-20-9

General procedure for the synthesis of 2,4-difluoro-5-nitrobenzonitrile from 2,4-difluorobenzonitrile: Potassium nitrate (16.4 g, 147.4 mmol) was slowly added to concentrated sulfuric acid (85 ml, 1582 mmol) at 0 °C, followed by 2,4-difluorobenzonitrile (11.0 g, 79.1 mmol) dropwise. The reaction mixture was stirred at this temperature for 4 hours. Upon completion of the reaction, the mixture was quenched by pouring into ice/water (800 mL). The precipitated solid product was collected by filtration and dried to give 2,4-difluoro-5-nitrobenzonitrile (13.8 g, 95% yield) as a white solid. The product was confirmed by NMR hydrogen spectrum (400 MHz, CDCl3): δ 8.48 (m, 1H), 7.24 (m, 1H).

References

[1] Patent: WO2006/87530, 2006, A1. Location in patent: Page/Page column 59
[2] Patent: WO2005/103010, 2005, A2. Location in patent: Page/Page column 40
[3] Patent: CN106854165, 2017, A. Location in patent: Paragraph 0106; 0107; 0138; 0139
[4] Journal of Medicinal Chemistry, 1994, vol. 37, # 4, p. 467 - 475
[5] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 15, p. 2019 - 2022

2,4-Difluoro-5-nitrobenzonitrile Preparation Products And Raw materials

Raw materials

2,4-Difluorobenzonitrile

Preparation Products

2,4-Difluoro-5-nitrobenzonitrile Suppliers

Global( 113)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Sphchem Co., Ltd. 021-56491756 13512199871 2819742715@qq.com China 3994 55
Suzhou Sibian Chemical Technology Co.,Ltd. 0512-65617459 18915409046 sales@sibian-chem.com China 1917 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Jia Xing Isenchem Co.,Ltd 66
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Sphchem Co., Ltd. 55
Suzhou Sibian Chemical Technology Co.,Ltd. 55
9ding chemical ( Shanghai) Limited 56

View Lastest Price from 2,4-Difluoro-5-nitrobenzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-DIFLUORO-5-NITROBENZONITRILE pictures 2019-12-26 2,4-DIFLUORO-5-NITROBENZONITRILE
67152-20-9
 $1.00 1KG 99% 100KG Career Henan Chemical Co

2,4-Difluoro-5-nitrobenzonitrile Spectrum

2,4-DIFLUORO-5-NITROBENZONITRILE(67152-20-9)1HNMR

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5-Cyano-2,4-difluoronitrobenzene 2,4-Difluoro-5-ntirobenzonitrile Benzonitrile, 2,4-difluoro-5-nitro- 2,4-difluoro-5-nitrobenzene nitrile 2,4-Difluoro-5-nitrobenzonitrile 67152-20-9 Aromatic Nitriles