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2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride

2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride Structure
2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride structure
CAS No.
84050-22-6
Chemical Name:
2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride
Synonyms
Terazosin-004-HCl;DPQ (hydrochloride);Terazosin Impurity5;2-PADQZ hydrochloride;Terazosin Impurity 6 HCl;Terazosin Impurity 3 HCl;2PADQZ hydrochloride,2 PADQZ hydrochloride;2-PIPERAZINYL-4-AMINO-6,7-DIMETHOXYQUINAZOLINEHCL;2-Piperazine-4-amino-6,7-dimethoxy quinazoline HCl;Piperazine amino dimethoxy quinaoline hydrochloride
CBNumber:
CB8686460
Molecular Formula:
C14H20ClN5O2
Molecular Weight:
325.79
MDL Number:
MFCD03840840
MOL File:
84050-22-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:51
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2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride Properties

CAS DataBase Reference 84050-22-6(CAS DataBase Reference)

2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA00G2MZ 2-PADQZ Hydrochloride 84050-22-6 1mg $95 2026-05-28 Buy
aablocks AA00G2MZ 2-PADQZ Hydrochloride 84050-22-6 5mg $194 2026-05-28 Buy
aablocks AA00G2MZ 2-PADQZ Hydrochloride 84050-22-6 10mg $279 2026-05-28 Buy
aablocks AA00G2MZ 2-PADQZ Hydrochloride 84050-22-6 25mg $436 2026-05-28 Buy
aablocks AA00G2MZ 2-PADQZ Hydrochloride 84050-22-6 50mg $585 2026-05-28 Buy
Product number Packaging Price Buy
AA00G2MZ 1mg $95 Buy
AA00G2MZ 5mg $194 Buy
AA00G2MZ 10mg $279 Buy
AA00G2MZ 25mg $436 Buy
AA00G2MZ 50mg $585 Buy

2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride Chemical Properties, Uses, Production

Uses

DPQ hydrochloride is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD+/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ hydrochloride inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ hydrochloride can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases[1][2][3].

in vivo

DPQ hydrochloride (10 mg/kg; intraperitoneal injection; single dose; 6 h) significantly attenuates lung inflammation, neutrophil infiltration, and vascular leakage in LPS-induced acute lung injury model of C57BL/6 mice, inhibiting NF-κB pathway activation[2].
DPQ hydrochloride (10 mg/kg; intraperitoneal injection; single dose; 4 weeks) improves cardiac function and reduced apoptosis and oxidative stress in myocardial infarction model of Wistar rats[3].

Animal Model:LPS-Induced Acute Lung Injury Model in C57BL/6 mice (male, 8-10 weeks old)[2]
Dosage:10 μg/kg (dissolved in 0.01% DMSO (PBS)
Administration:Intraperitoneal injection, 30 min after LPS chanllenge (7.5 mg/kg; ip; single dose)
Result:Reduced neutrophil infiltration (50% decrease), MPO activity (40% decrease), and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) in lungs. Restored vascular permeability (Evans blue extravasation reduced by 35%), and inhibited apoptotic cell death (TUNEL-positive cells decreased by 45%).
Suppressed NF-κB activation with reduced IkB-α degradation and p65 phosphorylation.
Animal Model:Wistar rats (male, 4 months old) + MI via coronary artery ligation[3]
Dosage:10 mg/kg (dissolved in DMSO)
Administration:Intraperitoneal injection, single dose immediately after MI induction
Result:Improved cardiac function (FS increased by 25%, EDD/ESD reduced by 15%), decreased apoptotic cardiomyocytes (TUNEL-positive cells reduced by 40%), and suppressed cleaved caspase-3 and PARP1 expression. Oxidative stress markers (O2-, nitrotyrosine) were reduced by 30-40% in infarcted myocardium.

IC 50

PARP-1

References

[1] Meli E, et al. Differential role of poly (ADP-ribose) polymerase-1in apoptotic and necrotic neuronal death induced by mild or intense NMDA exposure in vitro. Mol Cell Neurosci. 2004;25 (1) :172-180. DOI:10.1016/j.mcn.2003.09.016
[2] Wang G, et al. PARP-1 inhibitor, DPQ, attenuates LPS-induced acute lung injury through inhibiting NF-κB-mediated inflammatory response. PLoS One. 2013 Nov 21;8 (11) :e79757. DOI:10.1371/journal.pone.0079757
[3] Wang J, et al. Inhibition of poly (ADP-ribose) polymerase and inducible nitric oxide synthase protects against ischemic myocardial damage by reduction of apoptosis. Mol Med Rep. 2015 Mar;11 (3) :1768-76. DOI:10.3892/mmr.2014.2977

2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride Suppliers

Global Suppliers ( 48)
Supplier Tel Email Country ProdList Advantage
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Shanghai Han-Xiang Chemical Co., Ltd. 17754423994 candy@biochempartner.com China 3057 58
Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd. 0531-58897130 15508676053 drug_impurity@sdcclh.com China 2526 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Unipharm pharmaceutical industry Co., Ltd 536-8266195 +8613953676784 lee@unipharm-sd.com China 1200 58
Dayang Chem (Hangzhou) Co.,Ltd. +86-0571-88938639 17705817739 info@dycnchem.com China 52451 58
Career Henan Chemica Co +86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
Guangzhou Dreampharm Biotechnology Co., Ltd. 020-36607679; 13502246435 3008233746@qq.com China 9961 12
Jinan blalong chemical co. LTD 2710913286@qq.com 1513643261@qq.com China 14227 58
Supplier Advantage
Amadis Chemical Company Limited 58
Shanghai Han-Xiang Chemical Co., Ltd. 58
Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd. 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Unipharm pharmaceutical industry Co., Ltd 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
Career Henan Chemica Co 58
Guangzhou Dreampharm Biotechnology Co., Ltd. 12
Jinan blalong chemical co. LTD 58

View Latest Price from 2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-PADQZ hydrochloride pictures 2026-05-11 2-PADQZ hydrochloride
84050-22-6
 $70.00-233.00 99.61% 10g TargetMol Chemicals Inc.

2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride Spectrum

2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE(84050-22-6)1HNMR

84050-22-6 (2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride) Related Search:

2-Piperazine-4-amino-6,7-dimethoxyquinazoline Terazosin impurity 1-[4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl]-5-hydroxy-1-pentanone Terazosin IMpurity J Prazosin hydrochloride
Piperazine, 1-[[(2R)-tetrahydro-2-furanyl]carbonyl]- (9CI) Terazosin hydrochloride dihydrate [4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl][(5S)-tetrahydro-5-Methyl-2-furanyl]Methanone 1-(2-Furoyl)piperazine NSC 351869
[4-(4-AMino-7-hydroxy-6-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone Terazosin EP IMpurity D 6,7-DiMethoxy-2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)quinazolin-4(1H)-one 2,2'-(1,4-Piperazinediyl)bis[6,7-diMethoxy-4-quinazolinaMine] (R)-Terazosin
2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-diMethoxybenzoic Acid (Donepezil IMpurity) [4-(4-AMino-6-hydroxy-7-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone Terazosin EP Impurity O

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2-PIPERAZINYL-4-AMINO-6,7-DIMETHOXYQUINAZOLINEHCL 4-Amino-2-piperazin-6,7-dimethoxyquinolinehydrochloride 2-Piperazinyl-6,7-dimethoxyquinazolin-4-amine hydrochlorode Piperazine amino dimethoxy quinaoline hydrochloride 2-Piperazine-4-amino-6,7-dimethoxy quinazoline HCl 2-Piperazinyl-4-amino-6,7-dimethoxyquinazoline Hydrochloride 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINAOLINE HYDROCHLORIDE 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXYQUINAZOLINE(WXG00079) Terazosin-004-HCl Terazosin Impurity5 6,7-dimethoxy-N-(1-piperazinyl)-2-quinolinamine hydrochloride 2-PADQZ hydrochloride 2PADQZ hydrochloride,2 PADQZ hydrochloride 6,7-Dimethoxy-N-(piperazin-1-yl)quinolin-2-amine hydrochloride DPQ (hydrochloride) Terazosin Impurity 6 HCl Terazosin Impurity 3 HCl 2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride 84050-22-6 C14H19N5O2HCl