6-Methylcoumarin
- CAS No.
- 92-48-8
- Chemical Name:
- 6-Methylcoumarin
- Synonyms
- 6-Methyl;2H-1-BENZOPYRAN-2-ONE, 6-METHYL-;FEMA 2699;Toncarine;METHYL COUMARIN;6-METHYL-2H-CHROMEN-2-ONE;6-MC;6-methyl-coumari;6-Methyl-2-oxochronene;pralina
- CBNumber:
- CB8691534
- Molecular Formula:
- C10H8O2
- Molecular Weight:
- 160.17
- MDL Number:
- MFCD00006875
- MOL File:
- 92-48-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 73-76 °C (lit.) |
|---|---|
| Boiling point | 303 °C/725 mmHg (lit.) |
| Density | 1.0924 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| FEMA | 2699 | 6-METHYLCOUMARIN |
| FLAVIS Number | 13.012 | 6-Methylcoumarin |
| Flash point | 303°C/725mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO : ≥ 125 mg/mL (780.42 mM) |
| form | powder to crystal |
| color | White to Almost white |
| Odor | at 1.00 % in dipropylene glycol. coconut creamy powdery coumarinic tonka cinnamyl vanilla floral earthy |
| Odor Type | coconut |
| biological source | synthetic |
| JECFA Number | 1172 |
| BRN | 4222 |
| Major Application | flavors and fragrances |
| Cosmetics Ingredients Functions |
PERFUMING FRAGRANCE |
| InChI | 1S/C10H8O2/c1-7-2-4-9-8(6-7)3-5-10(11)12-9/h2-6H,1H3 |
| InChIKey | FXFYOPQLGGEACP-UHFFFAOYSA-N |
| SMILES | Cc1ccc2OC(=O)C=Cc2c1 |
| LogP | 1.85 |
| CAS DataBase Reference | 92-48-8(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | 6-METHYLCOUMARIN |
| FDA UNII | EHP8W0L01A |
| NIST Chemistry Reference | 2H-1-Benzopyran-2-one, 6-methyl-(92-48-8) |
| EPA Substance Registry System | 6-Methylcoumarin (92-48-8) |
| UNSPSC Code | 85151701 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H317-H334 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-42/43 | |||||||||
| Safety Statements | 22-36/37-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GN7792000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29321900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Resp. Sens. 1 Skin Sens. 1 |
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| Hazardous Substances Data | 92-48-8(Hazardous Substances Data) | |||||||||
| Toxicity | The acute oral LD50 value in rats was reported to be 1.68 g/kg (1.43-1.93 g/kg) (Moreno, 1973). The acute dermal LD50 value in rabbits exceeded 5 g/kg (Moreno, 1973). | |||||||||
| NFPA 704 |
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6-Methylcoumarin price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W269905 | 6-Methylcoumarin ≥99%, FCC, FG | 92-48-8 | 1 each | $57.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | W269905 | 6-Methylcoumarin ≥99%, FCC, FG | 92-48-8 | 1kg | $230 | 2026-04-30 | Buy |
| Sigma-Aldrich | W269905 | 6-Methylcoumarin ≥99%, FCC, FG | 92-48-8 | 5kg | $923 | 2026-04-30 | Buy |
| Sigma-Aldrich | M36203 | 6-Methylcoumarin ≥99% | 92-48-8 | 5g | $43.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | W269905 | 6-Methylcoumarin ≥99%, FCC, FG | 92-48-8 | 1 unit | $55.5 | 2025-07-31 | Buy |
6-Methylcoumarin Chemical Properties, Uses, Production
Chemical Properties
6-methylcoumarin is a white to almost white crystalline powder with has a somewhat coconut-like odor. the odor is also characterized as having a delicate fig or date sweetness. it has an almost bitter taste above 50 ppm, turning sweet and vanilla-like at lower levels. soluble in benzene, hot ethanol and non-volatile oil, insoluble in hot water.
Occurrence
Has apparently not been reported to occur in nature
Uses
6-Methylcoumarin is a synthetic fragrance in cosmetics, toiletries and soaps. It mainly used to prepare flavors such as coconut, vanilla and caramel.
Preparation
6-methylcoumarin is synthesized from p-cresol and fumaric acid. Preheat 72% sulfuric acid to 80 °C, add a mixture of fumaric acid and p-cresol, keep the reaction at 160-170 °C for 3-4 hours, cool, pour into crushed ice to precipitate a precipitate, and filter. The filtrate was extracted with benzene, and after adding benzene, the obtained crude product was subjected to vacuum distillation to obtain 6-methylcoumarin.
synthesis of 6-methylcoumarin: By heating 6-methyl coumarin-3-carboxylic acid to 300 to 340°C; by condensation of p-cresol-disulfonic acid with fumaric acid in the presence of H2SO4; by condensation of p-homosalicyclic aldehyde with malonic acid in the presence of aniline, followed by heating for the lactone; from salicylaldehyde with propionic acid anhydride and sodium propionate.
Definition
ChEBI: 6-methylcoumarin is a member of the class of coumarins that is coumarin in which the hydrogen at position 6 is replaced by a methyl group. It has a role as a fragrance and an allergen.
Aroma threshold values
Aroma characteristics at 1.0%: sweet vanilla cake, creamy, coconut, coumarin-like and powdery, with herbaceous hay and tonka-like nuances.
Taste threshold values
Taste characteristics at 5 ppm: coconut, sweet vanilla, dairy creamy, hay-like with anisic and coumarin nuances.
Synthesis Reference(s)
Tetrahedron, 62, p. 6918, 2006 DOI: 10.1016/j.tet.2006.04.080
General Description
6-methylcoumarin appears as white crystals with a flavor of vanilla. Insoluble in water. (NTP, 1992)
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Ketones, such as 6-Methylcoumarin, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.
Fire Hazard
6-Methylcoumarin is combustible.
Biochem/physiol Actions
Taste at 5 ppm
Safety Profile
Poison by subcutaneous route. Moderately toxic by ingestion. A skin irritant. Mutation data reported. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.
6-Methylcoumarin Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Taijilin Industrial Co., Ltd. | 02150630626 17717886015 | kate@tajilin.com | China | 1341 | 58 |
| Wuhan haorong Biotechnology Co., Ltd | 18186132299 18186132299 | 489527785@qq.com | China | 2606 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from 6-Methylcoumarin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 6-Methylcoumarin
92-48-8
|
$2.20-8.80 | 1kg | 99%min | 1000kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-07-24 | 6-Methylcoumarin
92-48-8
|
$29.00 | 99.87% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-28 | 6-Methylcoumarin
92-48-8
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 6-Methylcoumarin
92-48-8
- $2.20-8.80
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 6-Methylcoumarin
92-48-8
- $29.00
- 99.87%
- TargetMol Chemicals Inc.
-
- 6-Methylcoumarin
92-48-8
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
