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1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine

1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine Structure
1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine structure
CAS No.
99735-30-5
Chemical Name:
1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine
Synonyms
(R)-1-Benzyl-3-(Boc-amino)pyrrolidine;tert-Butyl N-(1-benzylpyrrolidin-3-yl)carbamate;1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine;1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine >N-benzyl-3-(R)-((1,1-dimethylethoxycarbonyl)amino)pyrrolidine;N-[1-(phenylmethyl)-3-pyrrolidinyl]carbamic acid tert-butyl ester;Carbamic acid,N-[1-(phenylmethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester
CBNumber:
CB8695855
Molecular Formula:
C16H24N2O2
Molecular Weight:
276.37
MDL Number:
MFCD00059039
MOL File:
99735-30-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:51
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1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine Properties

Melting point 113 °C
Boiling point 385.142±31.00 °C(Press: 760.00 Torr)(predicted)
Density 1.089±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. Sealed in dry,Room Temperature
form powder to crystal
pka 12.315±0.20(predicted)
color White to Almost white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
HS Code  9999999999

1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical B1357 1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine >98.0%(GC)(T) 99735-30-5 10g $52 2022-04-27 Buy
Apolloscientific OR311199 tert-Butyl N-(1-benzylpyrrolidin-3-yl)carbamate 98% 99735-30-5 1g $47 2026-06-04 Buy
Apolloscientific OR311199 tert-Butyl N-(1-benzylpyrrolidin-3-yl)carbamate 98% 99735-30-5 5g $70 2026-06-04 Buy
Apolloscientific OR311199 tert-Butyl N-(1-benzylpyrrolidin-3-yl)carbamate 98% 99735-30-5 25g $230 2026-06-04 Buy
Chem-Impex 43812 1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine ≥98%(GC) 99735-30-5 10G $70.41 2026-05-19 Buy
Product number Packaging Price Buy
B1357 10g $52 Buy
OR311199 1g $47 Buy
OR311199 5g $70 Buy
OR311199 25g $230 Buy
43812 10G $70.41 Buy

1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine Chemical Properties,Uses,Production

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

1-Benzyl-3-aminopyrrolidine

18471-40-4

1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE

99735-30-5

General procedure for the synthesis of 1-benzyl-3-(Boc-amino)pyrrolidine from di-tert-butyl dicarbonate and 1-benzylpyrrolidin-3-amine: 1-benzylpyrrolidin-3-amine (10 g, 57 mmol) was dissolved in 3M aqueous sodium hydroxide (21 ml) and tertiary butyl alcohol (114 ml) in a 500 ml reaction vessel. Di-tert-butyl dicarbonate (Boc2O; 13.07 g, 59.9 mmol) was slowly added to the above solution under stirring conditions. The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (2×). The organic layers were combined and washed sequentially with 0.1 N hydrochloric acid solution and saturated brine, then dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The crude product obtained was purified by silica gel column chromatography to afford 15.25 g of 1-benzyl-3-(Boc-amino)pyrrolidine as a white solid (97% yield). The structure of the product was confirmed by 1H-NMR (200 MHz, CDCl3) and LC/MS (M+H: 277).

References

[1] Patent: WO2008/54154, 2008, A1. Location in patent: Page/Page column 76; 80-81; 162-163; 168
[2] Patent: WO2007/52938, 2007, A1. Location in patent: Page/Page column 22-23

1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate 1-Benzyl-3-aminopyrrolidine tert-Butanol Sodium hydroxide

Preparation Products

1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine Suppliers

Global( 88)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Maya High Purity Chemicals +86 (573) 82222445 (0)18006601000 452520369 sales@maya-r.com China 11693 57
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489 Sales-JP@TCIchemicals.com Japan 28364 80
TCI Europe 320-37350700 sales@tcieurope.eu Europe 23654 75
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66
Maya High Purity Chemicals 57
T&W GROUP 58
Shanghai T&W Pharmaceutical Co., Ltd. 58
TOKYO CHEMICAL INDUSTRY CO., LTD. 80
TCI Europe 75

View Lastest Price from 1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE pictures 2019-07-12 1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE
99735-30-5
 $1.00 1KG 99% 25kg Career Henan Chemical Co

1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine Spectrum

1-BENZYL-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE(99735-30-5)1HNMR

99735-30-5(1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine)Related Search:

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(R)-1-Benzyl-3-(Boc-amino)pyrrolidine Carbamic acid,N-[1-(phenylmethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester tert-Butyl N-(1-benzylpyrrolidin-3-yl)carbamate N-benzyl-3-(R)-((1,1-dimethylethoxycarbonyl)amino)pyrrolidine N-[1-(phenylmethyl)-3-pyrrolidinyl]carbamic acid tert-butyl ester 1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine > 1-Benzyl-3-(tert-butoxycarbonylamino)pyrrolidine 99735-30-5 3-Aminopyrrolidines 3-Aminopyrrolidines (Racemic) 3-Aminopyrrolidines 3-Aminopyrrolidines (Racemic)