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17(R)-HDOHE

CAS No.
155976-53-7
Chemical Name:
17(R)-HDOHE
Synonyms
17(R)-HDHA;17(R)-HDOHE;17(R)-HDoHE Exclusive;SWTYBBUBEPPYCX-NGHKTGSUSA-N;17(R)-HYDROXY DOCOSAHEXAENOIC ACID;17(R)-Hydroxy-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA;17R-HYDROXY-4Z,7Z,10Z,13Z,15E,17R,19Z-DOCOSAHEXAENOIC ACID;17(R)-hydroxy-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid;4,7,10,13,15,19-Docosahexaenoic acid, 17-hydroxy-, (4Z,7Z,10Z,13Z,15E,17R,19Z)-
CBNumber:
CB8699499
Molecular Formula:
C22H32O3
Molecular Weight:
344.49
MDL Number:
MFCD08062145
MOL File:
155976-53-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:09:10

17(R)-HDOHE Properties

Boiling point 505.1±50.0 °C(Predicted)
Density 0.995±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
pka 4.58±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Health Hazard (GHS08)
GHS02,GHS08
Signal word  Danger
Hazard statements  H225-H350
Precautionary statements  P201-P202-P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P308+P313-P370+P378-P403+P235-P405-P501
NFPA 704
3
0 0

17(R)-HDOHE price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10005099 17(R)-HDHA ≥98% 155976-53-7 25μg $134 2026-04-30 Buy
Cayman Chemical 10005099 17(R)-HDHA ≥98% 155976-53-7 50μg $253 2026-04-30 Buy
Cayman Chemical 10005099 17(R)-HDHA ≥98% 155976-53-7 100μg $477 2026-04-30 Buy
Cayman Chemical 10005099 17(R)-HDHA ≥98% 155976-53-7 250μg $1058 2026-04-30 Buy
Product number Packaging Price Buy
10005099 25μg $134 Buy
10005099 50μg $253 Buy
10005099 100μg $477 Buy
10005099 250μg $1058 Buy

17(R)-HDOHE Chemical Properties, Uses, Production

Description

Resolvins are a group of polyhydroxylated metabolites of docosahexaenoic acid (DHA) found in the inflammatory exudates of aspirin-treated experimental animals. 17(R)-HDHA is the primary oxygenation product of DHA when exposed to aspirin-inhibited cyclooxygenase-2. 17(R)-HDHA serves as a precursor to resolvins and has intrinsic biological activity, such as the inhibition of TNFα-induced IL-1β expression in human glioma cells.

Uses

17(R)-HDHA (17(R)-HDoHE) is a pro-resolving mediator (SPM). 17(R)-HDHA enhances the differentiation of B cells toward the CD27(+)CD38(+) antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells. 17(R)-HDHA does not affect cell proliferation and is non-toxic to cells[1].

Definition

ChEBI: 17(R)-HDoHE is a polyunsaturated fatty acid that is (4Z,7Z,10Z,13Z,15E,19Z)-docosa-4,7,10,13,15,19-hexaenoic acid carrying a hydroxy substituent at the 17R-position. It has a role as a human xenobiotic metabolite and a mouse metabolite. It is a conjugate acid of a 17(R)-HDoHE(1-). It is an enantiomer of a 17(S)-HDoHE.

References

[1] Ramon S, et al. Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells. J Immunol. 2012 Jul 15;189(2):1036-42. DOI:10.4049/jimmunol.1103483

17(R)-HDOHE Preparation Products And Raw materials

Raw materials

Preparation Products

17(R)-HDOHE Suppliers

Global Suppliers ( 27)
Supplier Tel Email Country ProdList Advantage
Yichang Zhongyitai Trading Co., Ltd. 0717-6449896 13886658719 root@zhongyitai.com China 1978 58
Alfa Chemistry 1-516-6625404 support@alfa-chemistry.com United States 9170 60
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol 400-821-0310 15002144251 xuexiang.shao@tsbiochem.com China 29128 58
17(R)-HDOHE 17R-HYDROXY-4Z,7Z,10Z,13Z,15E,17R,19Z-DOCOSAHEXAENOIC ACID 17(R)-HYDROXY DOCOSAHEXAENOIC ACID SWTYBBUBEPPYCX-NGHKTGSUSA-N 17(R)-HDHA 17(R)-HDoHE Exclusive 4,7,10,13,15,19-Docosahexaenoic acid, 17-hydroxy-, (4Z,7Z,10Z,13Z,15E,17R,19Z)- 17(R)-hydroxy-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid 17(R)-Hydroxy-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA 155976-53-7