Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate
- CAS No.
- 2134-36-3
- Chemical Name:
- Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate
- Synonyms
- Ethyl 4-chloro-2-Methylpy...;Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate;Ethyl 4-chloro-2-methyl-5-pyrimidinecarboxylate;methyl 4-chloro-2-methylpyrimidine-5-carboxylate;4-Chloro-2-Methyl-pyriMidine-5-carboxylic acid ethyl ester;5-Pyrimidinecarboxylic acid, 4-chloro-2-methyl-, ethyl ester;ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE ISO 9001：2015 REACH
- CBNumber:
- CB8712031
- Molecular Formula:
- C8H9ClN2O2
- Molecular Weight:
- 200.62
- MDL Number:
- MFCD08275064
- MOL File:
- 2134-36-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405 |
Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | CAA13436 | Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate | 2134-36-3 | 5g | $413 | 2026-06-04 | Buy |
| Matrix Scientific | 112409 | Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate | 2134-36-3 | 1.00g | $605 | 2026-05-18 | Buy |
| Matrix Scientific | 112409 | Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate | 2134-36-3 | 5.00g | $1647 | 2026-05-18 | Buy |
| Synthonix | E7683 | Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate 97.0% | 2134-36-3 | 1g | $40 | 2026-05-06 | Buy |
| Synthonix | E7683 | Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate 97.0% | 2134-36-3 | 5g | $150 | 2026-05-06 | Buy |
Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate Chemical Properties,Uses,Production
Synthesis
53135-24-3
2134-36-3
General procedure for the synthesis of ethyl 4-chloro-2-methylpyrimidine-5-carboxylate from ethyl 2-methyl-4-hydroxypyrimidine-5-carboxylate: Phosphoryl chloride (50 mL, 23.33 mmol) was slowly added to ethyl 2-methyl-6-oxo-1,6-dihydropyrimidine-5-carboxylate (Intermediate 174, 4.25 g, 23.33 mmol). The resulting insoluble mixture was heated to reflux for 30 min. During the reaction, the product gradually dissolved in phosphoryl chloride while the feedstock remained insoluble. Upon completion of the reaction, the excess phosphoryl chloride was evaporated under reduced pressure. The residue was evaporated to dryness, redissolved in ethyl acetate (100 mL) and washed sequentially with water (75 mL) and saturated saline (75 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to give the crude product. The crude product was purified by fast silica gel column chromatography with an eluent of 10% to 30% ethyl acetate/isohexane gradient. The purified grades were collected and concentrated to dryness to afford ethyl 4-chloro-2-methylpyrimidine-5-carboxylate (2.70 g, 57.7% yield) as a colorless oil.1H NMR (400.132 MHz, CDCl3) δ 1.42 (3H, t), 2.78 (3H, s), 4.44 (2H, q), 9.05 (1H, s). Mass spectrum (ESI+) m/z (M + H)+ = 201; HPLC retention time tR = 2.17 min.
References
[1] Patent: US2009/264401, 2009, A1. Location in patent: Page/Page column 117-118
[2] Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 25, p. 435
[3] Shionogi Kenkyusho Nenpo, 1952, # 2, p. 76,78
[4] Chem.Abstr., 1957, p. 10008
[5] Journal of the Chemical Society, 1937, p. 367
Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6746 | 52 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Atop-Pharma (Shanghai) Technology Co., Ltd. | +86 (21) 5196-9732 | China | 996 | 57 | |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
View Lastest Price from Ethyl 4-chloro-2-methylpyrimidine-5-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE
2134-36-3
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-05-23 | ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE
2134-36-3
|
$50.00-100.00 | 1kg | 99% | 20 tons | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2020-02-04 | ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE
2134-36-3
|
$1.00 | 1KG | 98% HPLC | 10 tons | Career Henan Chemical Co |
-
- ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE
2134-36-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE
2134-36-3
- $50.00-100.00
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- ETHYL 4-CHLORO-2-METHYLPYRIMIDINE-5-CARBOXYLATE
2134-36-3
- $1.00
- 98% HPLC
- Career Henan Chemical Co
