Chlorobutanol
- CAS No.
- 57-15-8
- Chemical Name:
- Chlorobutanol
- Synonyms
- HCP;Chlorbutanol;CHLORETONE;1,1,1-TRICHLORO-2-METHYL-2-PROPANOL;Methaform;Chloreton;2-Propanol, 1,1,1-trichloro-2-methyl-;HRC;HCPH;PTN6
- CBNumber:
- CB8715683
- Molecular Formula:
- C4H7Cl3O
- Molecular Weight:
- 177.46
- MDL Number:
- MFCD00004461
- MOL File:
- 57-15-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Chlorobutanol European Pharmacopoeia (EP) Reference Standard | Y0002037 | 50 mg | $166 |
| SHP-1 Active human recombinant, expressed in E. coli, ≥90% (SDS-PAGE) | SRP0216 | 50 μg | $514 |
| PTPN6, active, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | SRP5076 | 10 μg | $431 |
| SHP-1 Active human recombinant, expressed in E. coli, ≥90% (SDS-PAGE) | SRP0216 | 20 μg | $531 |
| SHP-1 Active human recombinant, expressed in E. coli, ≥90% (SDS-PAGE) | SRP0216 | 1 unit | $480 |
| More product size | |||
| Melting point | ~78 °C |
|---|---|
| Boiling point | 173 °C |
| Density | 1.3170 (estimate) |
| Flash point | >110°C |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Slightly soluble in water, very soluble in ethanol (96 per cent), soluble in glycerol (85 per cent). |
| form | Solid |
| pka | 12.87±0.29(Predicted) |
| color | Hydrated crystals |
| Odor | camphor odor |
| biological source | rabbit |
| Water Solubility | 8g/L(20 ºC) |
| Specific Activity | 820-1110nmol/min·mg |
| Stability | Stable. Generates toxic fumes on combustion. |
| Cosmetics Ingredients Functions | PRESERVATIVE |
| InChI | 1S/C4H7Cl3O/c1-3(2,8)4(5,6)7/h8H,1-2H3 |
| InChIKey | OSASVXMJTNOKOY-UHFFFAOYSA-N |
| SMILES | ClC(Cl)(Cl)C(O)(C)C |
| LogP | 2.030 |
| CAS DataBase Reference | 57-15-8(CAS DataBase Reference) |
| FDA UNII | HM4YQM8WRC |
| NCI Dictionary of Cancer Terms | HCP |
| NIST Chemistry Reference | 2-(Trichloromethyl)-2-propanol(57-15-8) |
| EPA Substance Registry System | 1,1,1-Trichloro-2-methyl-2-propanol (57-15-8) |
| UNSPSC Code | 41116107 |
| NACRES | NA.41 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Hazardous Substances Data | 57-15-8(Hazardous Substances Data) |
| Toxicity | MLD orally in dogs, rabbits (mg/kg): 238, 213 (Impens) |
Chlorobutanol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0002037 | Chlorobutanol European Pharmacopoeia (EP) Reference Standard | 57-15-8 | 50 mg | $166 | 2026-03-19 | Buy |
| Sigma-Aldrich | SRP0216 | SHP-1 Active human recombinant, expressed in E. coli, ≥90% (SDS-PAGE) | 50 μg | $514 | 2026-03-19 | Buy | |
| Sigma-Aldrich | SRP5076 | PTPN6, active, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution | 10 μg | $431 | 2026-03-19 | Buy | |
| Sigma-Aldrich | SRP0216 | SHP-1 Active human recombinant, expressed in E. coli, ≥90% (SDS-PAGE) | 20 μg | $531 | 2026-03-19 | Buy | |
| Sigma-Aldrich | SRP0216 | SHP-1 Active human recombinant, expressed in E. coli, ≥90% (SDS-PAGE) | 1 unit | $480 | 2025-07-31 | Buy |
Chlorobutanol Chemical Properties,Uses,Production
Chemical Properties
White or almost white, crystalline powder or colourless crystals, sublimes readily
Chemical Properties
Volatile, colorless or white crystals with a musty, camphoraceous odor.
Originator
Chlorobutanol,Narchem
Uses
Chlorobutanol is used as a preservative and sedative. It has also been shown to exhibit antibacterial properties.
Uses
Plasticizer for cellulose esters and ethers, preservative for biological fluids and solutions, antimicrobial agent, anesthetic in dentistry.
Production Methods
Chlorobutanol is prepared by condensing acetone and chloroform in the presence of solid potassium hydroxide.
Definition
ChEBI: Chlorobutanol is a tertiary alcohol.
Manufacturing Process
33 g (0.59 mol) of powdered potassium hydroxide was added in small amounts to a solution of 50 g (0.86 mol) of acetone in 100 g (0.84 mol) of chloroform to form a reaction mixture containing approximately 0.7 mol of KOH per mol of chloroform. The mixture was chilled to a temperature below 0°C, thoroughly agitated, and than allowed to stand at temperature of about 0°C for 24 hours. The mixture was then filtered and the filtrate was distilled. The fraction boiling within the range of 165-175°C was poured into an equal amount of water to precipitate the 1,1,1-trichloro-tert-butyl alcohol. The precipitated 1,1,1-trichloro-tert-butyl alcohol was filtered and recrystallized from an ethanol-water mixture and air dried. The yield of 1,1,1-trichloro-tertbutyl alcohol was 6 g, that is, somewhat less than 4% of the theoretical yield based on chloroform charged. When calculated on the basis of chloroform consumed the yield was about 15%.
Therapeutic Function
Hypnotic, Anesthetic, Antiseptic, Pharmaceutic aid, Ophthalmologic
Synthesis Reference(s)
Journal of the American Chemical Society, 70, p. 1189, 1948 DOI: 10.1021/ja01183a092
Hazard
Action similar to chloral hydrate. Combustible.
Pharmaceutical Applications
Chlorobutanol is primarily used in ophthalmic or parenteral dosage forms as an antimicrobial preservative at concentrations up to 0.5% w/v. It is commonly used as an antibacterial agent for epinephrine solutions, posterior pituitary extract solutions, and ophthalmic preparations intended for the treatment of miosis. It is especially useful as an antibacterial agent in nonaqueous formulations. Chlorobutanol is also used as a preservative in cosmetics ; as a plasticizer for cellulose esters and ethers; and has been used therapeutically as a mild sedative and local analgesic in dentistry.
Biological Activity
In mammary epithelial cells, protein tyrosine phosphatase, non-receptor type 6 (PTPN6) controls EGFR (epidermal growth factor receptor) signaling. It participates in the JAK/ST at (janus kinase/signal transducers and activators of transcription) signaling pathway. PTPN6 regulates cytokine receptors like interleukin- 3 (IL-3) and erythropoietin.
Safety Profile
Poison by ingestion. A narcotic. A skin and eye irritant. Mutation data reported. See also CHLORAL HYDRATE, whch acts similarly. Dangerous; can react with oxidizing materials. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl-. See also PHOSGENE.
Safety
Chlorobutanol is widely used as a preservative in a number of
pharmaceutical formulations, particularly ophthalmic preparations.
Although animal studies have suggested that chlorobutanol
may be harmful to the eye, in practice the widespread use of
chlorobutanol as a preservative in ophthalmic preparations has
been associated with few reports of adverse reactions. A study of the
irritation potential of a local anesthetic on the murine cornea
indicated significant corneal surface damage in the presence of
0.5% w/v chlorobutanol, which may be related to the preservative’s
effective concentration. Reported adverse reactions to chlorobutanol
include: cardiovascular effects following intravenous
administration of heparin sodium injection preserved with chlorobutanol; neurological effects following administration of a
large dose of morphine infusion preserved with chlorobutanol;
and hypersensitivity reactions, although these are regarded as
rare.
The lethal human dose of chlorobutanol is estimated to be
50–500 mg/kg.
LD50 (dog, oral): 0.24 g/kg
LD50 (mouse, oral): 0.99 g/kg
LD50 (rabbit, oral): 0.21 g/kg
storage
Chlorobutanol is volatile and readily sublimes. In aqueous solution,
degradation to carbon monoxide, acetone and chloride ion is
catalyzed by hydroxide ions. Stability is good at pH 3 but becomes
progressively worse with increasing pH. The half-life at pH 7.5
for a chlorobutanol solution stored at 258℃ was determined to be
approximately 3 months. In a 0.5% w/v aqueous chlorobutanol
solution at room temperature, chlorobutanol is almost saturated
and may crystallize out of solution if the temperature is reduced.
Losses of chlorobutanol also occur owing to its volatility, with
appreciable amounts being lost during autoclaving; at pH 5 about
30% of chlorobutanol is lost. Porous containers result in losses
from solutions, and polyethylene containers result in rapid loss.
Losses of chlorobutanol during autoclaving in polyethylene
containers may be reduced by pre-autoclaving the containers in a
solution of chlorobutanol; the containers should then be used
immediately. There is also appreciable loss of chlorobutanol
through stoppers in parenteral vials.
The bulk material should be stored in an airtight container at a
temperature of 8–158℃.
Incompatibilities
Owing to problems associated with sorption, chlorobutanol is incompatible with plastic vials, rubber stoppers, bentonite, magnesium trisilicate, polyethylene, and polyhydroxyethylmethacrylate, which has been used in soft contact lenses. To a lesser extent, carboxymethylcellulose and polysorbate 80 reduce antimicrobial activity by sorption or complex formation.
Toxics Screening Level
The ITSL for chlorobutanol has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time.
Regulatory Status
Included in the FDA Inactive Ingredients Database (IM, IV, and SC
injection; inhalations; nasal, otic, ophthalmic, and topical preparations).
Labeling must state ‘contains chlorobutanol up to 0.5%.’
Included in nonparenteral and parenteral medicines licensed in the
UK. Included in the Canadian List of Acceptable Non-medicinal
Ingredients.
In the UK, the maximum concentration of chlorobutanol
permitted for use in cosmetics, other than foams, is 0.5%. It is
not suitable for use in aerosols.
Chlorobutanol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangxi Alpha Hi-tech Pharmaceutical Co., Ltd | 510-85010237 | overseamarketing@alphahi-tech.com | CHINA | 41 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 | hbjbtech@163.com | China | 1000 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18633929156 | admin@hblongbang.com | China | 972 | 58 |
| HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 | L18532138899@163.com | China | 939 | 58 |
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +15184799099 | lbaochemicals@gmail.com | China | 671 | 58 |
View Lastest Price from Chlorobutanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-16 | Chlorobutanol
57-15-8
|
US $0.00 / kg | 1kg | 98% | Customise | Hefei Lbao Physical & Chemical Science Co.,Ltd | |
 |
2026-04-16 | Chlorobutanol
57-15-8
|
US $43.00 / mL | 99.51% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-16 | Chlorobutanol
57-15-8
|
US $43.00 / mL | 99.51% | 10g | TargetMol Chemicals Inc. |
-
- Chlorobutanol
57-15-8
- US $0.00 / kg
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- Chlorobutanol
57-15-8
- US $43.00 / mL
- 99.51%
- TargetMol Chemicals Inc.
-
- Chlorobutanol
57-15-8
- US $43.00 / mL
- 99.51%
- TargetMol Chemicals Inc.
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