3-Chloroisonicotinic acid ethyl ester
- CAS No.
- 211678-96-5
- Chemical Name:
- 3-Chloroisonicotinic acid ethyl ester
- Synonyms
- ethyl 3-chloropyridine-4-carboxylate;3-CHLOROPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER;Ethyl 3-chloronicotinate;Ethyl 3-chloroisonicotinate;3-Chloroisonicotinic acid ethyl ester;4-Pyridinecarboxylic acid, 3-chloro-, ethyl ester;4-Pyridinecarboxylicacid,3-chloro-,ethylester(9CI)
- CBNumber:
- CB8729462
- Molecular Formula:
- C8H8ClNO2
- Molecular Weight:
- 185.61
- MDL Number:
- MFCD03411706
- MOL File:
- 211678-96-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| HS Code | 2933399990 |
3-Chloroisonicotinic acid ethyl ester price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR950143 | 3-Chloropyridine-4-carboxylic acid ethyl ester >98% | 211678-96-5 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR950143 | 3-Chloropyridine-4-carboxylic acid ethyl ester >98% | 211678-96-5 | 5g | $32 | 2026-06-04 | Buy |
| Apolloscientific | OR950143 | 3-Chloropyridine-4-carboxylic acid ethyl ester >98% | 211678-96-5 | 25g | $142 | 2026-06-04 | Buy |
| Apolloscientific | OR950143 | 3-Chloropyridine-4-carboxylic acid ethyl ester >98% | 211678-96-5 | 100g | $519 | 2026-06-04 | Buy |
| Apolloscientific | OR950143 | 3-Chloropyridine-4-carboxylic acid ethyl ester >98% | 211678-96-5 | 500g | $2488 | 2026-06-04 | Buy |
3-Chloroisonicotinic acid ethyl ester Chemical Properties, Uses, Production
Synthesis
64-17-5
211678-96-5
General procedure for the synthesis of ethyl 3-chloroisonicotinate from ethanol: 3-chloroisonicotinate (1.0 g, 6.35 mmol) was suspended in thionyl chloride (10 ml) and heated to reflux for 2.5 hours. Upon completion of the reaction, the solution was cooled to room temperature, concentrated to dryness and subsequently azeotropized with toluene (10 ml) to give an oil. The resulting oily substance was slowly added dropwise to a cooled mixture of ethanol (15 ml) and diisopropylethylamine (DIPEA) at 0°C, the dropwise process was controlled to be completed within 10 minutes. The reaction mixture was stirred at room temperature for 18 hours. At the end of the reaction, the reaction solution was concentrated in vacuum, diluted with water (20 ml) and extracted with ethyl acetate (30 ml). The organic phase was dried over anhydrous sodium sulfate and concentrated to give ethyl 3-chloroisonicotinate as an orange oil (1.1 g, 94% yield). The product was characterized by 1H NMR (CDCl3, 400MHz): δ 8.72 (s, 1H), 8.59 (d, J = 4.9Hz, 1H), 7.63 (dd, J = 4.9Hz, 0.5Hz, 1H), 4.44 (q, J = 7.3Hz, 2H), 1.42 (t, J = 7.3Hz, 3H).
References
[1] Patent: WO2008/24724, 2008, A1. Location in patent: Page/Page column 68-69
3-Chloroisonicotinic acid ethyl ester Preparation Products And Raw materials
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