Clostebol
- CAS No.
- 1093-58-9
- Chemical Name:
- Clostebol
- Synonyms
- Chlortestosterone;CLOSTEBOL;Cholostebol;17β-Clostebol;Clostebol VETRANAL;Clostebol Standard;Clostebol USP/EP/BP;C11691600 Clostebol;ClostebolAcetateBase;4-CHLOROTESTOSTERONE
- CBNumber:
- CB8730750
- Molecular Formula:
- C19H27ClO2
- Molecular Weight:
- 322.87
- MDL Number:
- MFCD00198396
- MOL File:
- 1093-58-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Clostebol ≥98% | 21168 | 1mg | $49 |
| Clostebol ≥98% | 21168 | 5mg | $120 |
| Clostebol (1 mg/ml in Acetonitrile) | TRC-KIT3790-5X1ML | 5x1mL | $887 |
| Clostebol | 4111CA | 1mg | $147 |
| CLOSTEBOL 95.00% | SHG0004763 | 10MG | $750.75 |
| More product size | |||
| Melting point | 188-190° |
|---|---|
| alpha | D20 +148° (CHCl3) |
| Boiling point | 448.4±45.0 °C(Predicted) |
| Density | 1.0514 (estimate) |
| solubility | DMF: 20 mg/mL; DMSO: 30 mg/mL; DMSO:PBS (pH 7.2) (1:10): 0.09 mg/mL; Ethanol: 20 mg/mL |
| form | A crystalline solid |
| pka | 14.99±0.70(Predicted) |
| CAS DataBase Reference | 1093-58-9(CAS DataBase Reference) |
| FDA UNII | Z7D4G976SH |
| NIST Chemistry Reference | 4-Chloro-17beta-hydroxyandrost-4-en-3-one(1093-58-9) |
Clostebol price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21168 | Clostebol ≥98% | 1093-58-9 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 21168 | Clostebol ≥98% | 1093-58-9 | 5mg | $120 | 2026-04-30 | Buy |
| TRC | TRC-KIT3790-5X1ML | Clostebol (1 mg/ml in Acetonitrile) | 1093-58-9 | 5x1mL | $887 | 2026-06-03 | Buy |
| AK Scientific | 4111CA | Clostebol | 1093-58-9 | 1mg | $147 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0004763 | CLOSTEBOL 95.00% | 1093-58-9 | 10MG | $750.75 | 2021-12-16 | Buy |
Clostebol Chemical Properties,Uses,Production
Description
Clostebol (Item No. 21168) is an analytical reference standard that is categorized as an androgenic anabolic steroid. Clostebol is a chlorinated form of testosterone (Item Nos. 15645 | ISO60154) that has been used as an athletic performance enhancer and to fatten cattle. It is also detectible in urine. Formulations containing clostebol have been used to treat osteoporosis, anorexia, and certain types of liver disease. Clostebol is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.
Uses
Clostebol is an anabolic steroid. This is a controlled substance.
Definition
ChEBI: Clostebol is a 3-hydroxy steroid. It has a role as an androgen.
Synthesis
Clostebol can be synthesized from 4,5-Epoxy-androstan-17β-ol-3-one by acidification with 25% hydrochloric acid.
Procedure：8.50 g epoxide (4,5-Epoxy-androstan-17β-ol-3-one) was dissolved in 150 ml Acetone and treated with 14 ml of 25% hydrochloric
acid. An immediate color shift of the reaction mixture from light yellow to deep blue can be
observed. After stirring for 30 h at room temperature, a complete conversion of the epoxide (4,5-Epoxy-androstan-17β-ol-3-one)
can be monitored by TLC. The reaction mixture was diluted with 400 ml water, leading to the
formation of a blue-black solid precipitating from the solution. After evaporation of acetone, the remaining aqueous solution was extracted several times with
200 ml dichloromethane. The combined organic extracts were washed with saturated sodium
bicarbonate solution and sodium chloride solution before drying over magnesium sulfate.
The crude product was chromatographed on silica gel by using hexane-ethyl acetat (1:1) and
followed by a recrystallization from acetone. The isolated product Clostebol was obtained as
yellowish crystals (4.50 g; 51%).
References
[1] JIANGHAI LU. New clostebol metabolites in human urine by liquid chromatography time-of-flight tandem mass spectrometry and their application for doping control[J]. Journal of Mass Spectrometry, 2015, 50 1: 191-197. DOI: 10.1002/jms.3517
[2] G DEBRUYCKERE C V P R de Sagher. Clostebol-positive urine after consumption of contaminated meat.[J]. Clinical chemistry, 1992, 38 9: 1869-1873.
[3] HENRIQUE M G PEREIRA. Incidental clostebol contamination in athletes after sexual intercourse.[J]. Clinical chemistry, 2004, 50 2: 456-457. DOI: 10.1373/clinchem.2003.022210
[4] WILLI SCHNZER Manfred D. Metabolism of anabolic steroids in man: synthesis and use of reference substances for identification of anabolic steroid metabolites[J]. Analytica Chimica Acta, 1993, 275 1: Pages 23-48. DOI: 10.1016/0003-2670(93)80274-o
[5] L CALDERóN-GARCIDUEAS. 8-hydroxy-2’-deoxyguanosine, a major mutagenic oxidative DNA lesion, and DNA strand breaks in nasal respiratory epithelium of children exposed to urban pollution.[J]. Environmental Health Perspectives, 1999, 107 6: 469-474. DOI: 10.1289/ehp.107-1566580
[6] PATRICIA CRABBE. Influence of the Hapten Conjugation Site on the Characteristics of Antibodies Generated against Metabolites of Clostebol Acetate[J]. Journal of Agricultural and Food Chemistry, 2000, 48 8: 3633-3638. DOI: 10.1021/jf9906984
Clostebol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32288 | 55 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| ShangHai Anpel Co, Ltd. | 18502138905 | shanpel@anpel.com.cn | China | 9604 | 58 |
| Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 13120558703 | sales@scrbio.com | China | 9881 | 58 |
| Shanghai Kaisen Biotechnology Co., Ltd | 17558870519 | sales02@chemsoon.com | China | 1924 | 58 |
| Shanghai Weiyite Biotechnology Co., Ltd | 15317051735 | zhaojing@wytsci.com | China | 10000 | 58 |
| Shanghai Titan Scientific Co.,Ltd | 18616708014 | yhx@titansci.com | China | 9999 | 58 |
| Hubei Yangxin Medical Technology Co., Ltd. | 07143299675 13092790750 | 3003355938@qq.com | China | 9541 | 58 |
