FMOC-SER(AC)-OH
- CAS No.
- 171778-17-9
- Chemical Name:
- FMOC-SER(AC)-OH
- Synonyms
- FMOC-SER(AC)-OH;FMOC-SERINE(AC)-OH;FMOC-O-ACETYL-L-SERINE;O-Acetyl-N-Fmoc-L-serine;Fmoc-O-acetyl-L-serine99%;N-ALPHA-FMOC-O-ACETYL-L-SERINE;(9H-Fluoren-9-yl)MethOxy]Carbonyl Ser(Ac)-OH;O-Acetyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-ACETYL-L-SERINE;L-Serine, O-acetyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
- CBNumber:
- CB8732446
- Molecular Formula:
- C20H19NO6
- Molecular Weight:
- 369.37
- MDL Number:
- MFCD00077070
- MOL File:
- 171778-17-9.mol
| Boiling point | 611.2±55.0 °C(Predicted) |
|---|---|
| Density | 1.322 |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.27±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| optical activity | -19.4°(C=0.01g/ml ETOH) |
| InChI | InChI=1S/C20H19NO6/c1-12(22)26-11-18(19(23)24)21-20(25)27-10-17-15-8-4-2-6-13(15)14-7-3-5-9-16(14)17/h2-9,17-18H,10-11H2,1H3,(H,21,25)(H,23,24)/t18-/m0/s1 |
| InChIKey | HSGIKRPBGCJRDB-SFHVURJKSA-N |
| SMILES | C(O)(=O)[C@H](COC(C)=O)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
FMOC-SER(AC)-OH price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F861043 | Fmoc-Ser(Ac)-OH | 171778-17-9 | 100mg | $45 | 2021-12-16 | Buy |
| TRC | F861043 | Fmoc-Ser(Ac)-OH | 171778-17-9 | 500mg | $65 | 2021-12-16 | Buy |
| Usbiological | 238590 | Fmoc-O-acetyl-L-serine 99+% | 171778-17-9 | 1g | $222 | 2021-12-16 | Buy |
| Usbiological | 277042 | Fmoc-O-acetyl-L-serine | 171778-17-9 | 500mg | $333 | 2021-12-16 | Buy |
| Chem-Impex | 03771 | Fmoc-O-acetyl-L-serine,98%(HPLC) 98%(HPLC) | 171778-17-9 | 25G | $380.8 | 2021-12-16 | Buy |
FMOC-SER(AC)-OH Chemical Properties,Uses,Production
Uses
Fmoc-Ser(Ac)-OH (Fmoc-O-acetyl-L-serine) is a Serine derivative. Fmoc-Ser(Ac)-OH can be used for the preparation of broad-spectrum coronavirus membrane fusion inhibitor[1].
Synthesis
5147-00-2
82911-69-1
171778-17-9
General procedure for the synthesis of Fmoc-O-acetyl-L-serine from O-acetyl-L-serine and 9-fluorenylmethyl-N-succinimidyl carbonate: O-acetyl-L-serine (337 g, 1.0 mol) was dissolved in 10% aqueous sodium carbonate solution and stirred until completely dissolved. 9-Fluorenylmethyl-N-succinimidyl carbonate dissolved in ethyl acetate (340 to 3400 ml) was slowly added dropwise at 20-30°C for 30-60 minutes. After the dropwise addition was completed, the reaction was continued with stirring for 1-8 hours. After completion of the reaction, the excess 9-fluorenylmethyl-N-succinimidyl carbonate was separated and removed. The aqueous phase was acidified with hydrochloric acid to pH=1-2 and then extracted with ethyl acetate (30,000 ml). The organic phase was washed with water to remove residual hydrochloric acid and concentrated to give an oil. White crystals were precipitated from ethyl acetate by crystallization, filtered and dried to give 273.0 g of Nα-9-fluorenylmethoxycarbonyl-O-acetyl-L-serine in 74.0% overall yield. The product was 99.56% pure by HPLC, with a melting point of 161.5-162.2°C and specific optical rotation [α]D=-22.6 (c=1, DMF).
References
[1] Patent: CN107501127, 2017, A. Location in patent: Paragraph 0014; 0028; 0029; 0030
FMOC-SER(AC)-OH Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8617390183901 | cynthia@enlaibio.com | China | 1100 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 | |
| GL Biochem(Binhai) Ltd. | +86-021-61263370 +8615301650015 | wuqiuyan@glschina.com | China | 2975 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9629 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
View Lastest Price from FMOC-SER(AC)-OH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-15 | Fmoc-Ser(Ac)-OH
171778-17-9
|
US $0.00-0.00 / kg | 1kg | 99+ | 1T | Sichuan HongRi Pharma-Tech Co.,Ltd | |
 |
2025-05-01 | Fmoc-Ser(Ac)-OH
171778-17-9
|
US $34.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Fmoc-Ser(Ac)-OH
171778-17-9
- US $0.00-0.00 / kg
- 99+
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Fmoc-Ser(Ac)-OH
171778-17-9
- US $34.00 / mg
- TargetMol Chemicals Inc.
