CARNOSOL
- CAS No.
- 5957-80-2
- Chemical Name:
- CARNOSOL
- Synonyms
- carnol;CARNOSOL;BCL6-IN-13;D-α-Alanine;Carnosol-RM;CARNOSOL(RG);CARNOSOL USP/EP/BP;Carnosol (Standard);Carnosol, 10 mM in DMSO;Carnosol(P)(Request Quote)
- CBNumber:
- CB8736565
- Molecular Formula:
- C20H26O4
- Molecular Weight:
- 330.42
- MDL Number:
- MFCD02752467
- MOL File:
- 5957-80-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 240~242℃ |
|---|---|
| Boiling point | 524.8±50.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO:66.0(Max Conc. mg/mL);199.74(Max Conc. mM) |
| form | Solid |
| pka | 8.91±0.40(Predicted) |
| color | White |
| biological source | Rosemarinus officinalis L. leaves |
| Major Application | food and beverages |
| InChI | InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1 |
| InChIKey | XUSYGBPHQBWGAD-PJSUUKDQSA-N |
| SMILES | C1(C)(C)[C@@]2([H])[C@]3(C(=O)O[C@@]([H])(C2)C2=C3C(O)=C(O)C(C(C)C)=C2)CCC1 |
| LogP | 2.832 (est) |
| FDA UNII | 483O455CKD |
| UNSPSC Code | 85151701 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P280-P302+P352 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29322090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Skin Sens. 1 |
| Hazardous Substances Data | 5957-80-2(Hazardous Substances Data) |
CARNOSOL price More Price(85)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL80150 | Carnosol phyproof® Reference Substance | 5957-80-2 | 10 mg | $524 | 2026-04-30 | Buy |
| Sigma-Aldrich | C9617 | Carnosol | 5957-80-2 | 5mg | $417 | 2026-04-30 | Buy |
| Sigma-Aldrich | 49702 | Carnosol analytical standard | 5957-80-2 | 10mg | $810 | 2026-04-30 | Buy |
| Cayman Chemical | 89800 | Carnosol ≥98% | 5957-80-2 | 1mg | $47 | 2026-04-30 | Buy |
| Cayman Chemical | 89800 | Carnosol ≥98% | 5957-80-2 | 5mg | $208 | 2026-04-30 | Buy |
CARNOSOL Chemical Properties, Uses, Production
Description
Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.
Description
Carnosol is a phenol that has been found in rosemary (R. officinalis) and has diverse biological activities. It decreases nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at concentrations ranging from 6 to 25 μM. Carnosol scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays. It inhibits 5-lipoxygenase (5-LO; IC50 = 0.1 μM for the recombinant human enzyme) and the synthesis of leukotrienes in human polymorphonuclear leukocytes (PMNs; IC50 = 7 μM). In vivo, carnosol (200 mg/kg) reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis.
Chemical Properties
White powder
Uses
Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen.
Definition
ChEBI: Carnosol is a diterpenoid.
Cytotoxicity
IC50 (μg/mL): 65 (HL-60), 58 (K562), 50(Hep G2), 48 (MCF-7), 53 (MOLT-4)(Farimani et al. 2012)
IC50 (μg/mL): 61.46 (AGS) (Areche et al.2009)
IC50 (μg/mL): 2 (P388) (Aoyagi et al.2006)
IC50 (μg/mL): 1.19 (A2780), 3.30(SW1573), 8.59 (WiDr), 7.93 (T-47D),1.29 (HBL-100) (Guerrero et al. 2006).
Synthesis
Take 2000g of dried rosemary branches and leaves, add 14L of petroleum ether, reflux extraction for 3 times, 3 hours each time, merge the 3 extracts, concentrate and recover the petroleum ether, get the extract; dissolve the extract with 40% ethanol, filter to remove insoluble matter, get 1000ml of mother liquor as adsorbent, adsorb the adsorbent with 500ml of D101 large pore adsorbent resin, adsorb and then elute the eluent with 1000ml of purified water, and then elute with 1500ml of 90% ethanol. Elution, and then eluted with 1500 ml of 90% ethanol solution, the eluent is divided into 6 sections, combined with the middle 4; combined eluent concentrated to 100 ml under reduced pressure, add 200 ml of water, stir to precipitate, and leave for 3 hours; centrifuged to get the precipitate containing sage bitter endolipids; precipitate dissolved with 200 ml of ethyl acetate, to which 200 ml of petroleum ether was added, stirring, precipitate precipitate; filtered to get the Sage bitter endolipid crude product, the crude product with 800 ml of anhydrous ethanol crystallization, to get the sage bitter endolipid crystals; filtration, drying, to get the crystals 13.6 g, HPLC detection of sage bitter endolipid content of 96.1%.
References
[1] MARION MAN-YING CHAN Hsing I H Chi Tang Ho. Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production[J]. Cancer letters, 1995, 96 1: Pages 23-29. DOI: 10.1016/0304-3835(95)03913-h
[2] O I ARUOMA. Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid.[J]. Xenobiotica, 1992, 22 2: 257-268. DOI: 10.3109/00498259209046624
[3] DANIEL POECKEL . Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes[J]. Biochemical pharmacology, 2008, 76 1: Pages 91-97. DOI: 10.1016/j.bcp.2008.04.013
[4] KEITH SINGLETARY Matthew W Christopher MacDonald. Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation[J]. Cancer letters, 1996, 104 1: Pages 43-48. DOI: 10.1016/0304-3835(96)04227-9
CARNOSOL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Ltd. | 82633860 18982077548 | cwb1@biopurify.cn | China | 4630 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Shenzhen Sungening Bio-Tech Co., Ltd | +86-0755-89668383 | sales@sungening.com | China | 1319 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
View Latest Price from CARNOSOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | CARNOSOL
5957-80-2
|
20mg | ≥98% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | ||
 |
2026-07-27 | Carnosol
5957-80-2
|
$39.00-113.00 | 99.51% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-22 | Carnosol
5957-80-2
|
1kg | 99.8% | 1000 kg | BINBOBIO CO., LTD. |
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