Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-Chloro-5-thiophenecarboxaldehyde

2-Chloro-5-thiophenecarboxaldehyde

2-Chloro-5-thiophenecarboxaldehyde Structure
2-Chloro-5-thiophenecarboxaldehyde structure
CAS No.
7283-96-7
Chemical Name:
2-Chloro-5-thiophenecarboxaldehyde
Synonyms
BUTTPARK 29\08-47;TIMTEC-BB SBB004100;2-Chloro-5-thiophene;oro-2-thiophenecarboxaL;Rivaroxaban Impurity 125;Rivaroxaban Impurity 100;Chlorothiophene Aldehyde;Rivaroxaban Impurity RC30;2-CHLORO-5-FORMYLTHIOPHENE;5-CHLORO-2-FORMYLTHIOPHENE
CBNumber:
CB8737416
Molecular Formula:
C5H3ClOS
Molecular Weight:
146.59
MDL Number:
MFCD00047090
MOL File:
7283-96-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:23:44
Request For Quotation

2-Chloro-5-thiophenecarboxaldehyde Properties

Boiling point 99 °C/21 mmHg (lit.)
Density 1.376 g/mL at 25 °C (lit.)
refractive index n20/D 1.604(lit.)
Flash point 208 °F
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Crystalline Powder or Solid
color White to tan
Sensitive Air Sensitive
InChI InChI=1S/C5H3ClOS/c6-5-2-1-4(3-7)8-5/h1-3H
InChIKey VWYFITBWBRVBSW-UHFFFAOYSA-N
SMILES C1(C=O)SC(Cl)=CC=1
CAS DataBase Reference 7283-96-7(CAS DataBase Reference)
FDA UNII DPU4RVB7PT
NIST Chemistry Reference 2-Thiophenecarboxaldehyde, 5-chloro-(7283-96-7)
EPA Substance Registry System 2-Thiophenecarboxaldehyde, 5-chloro- (7283-96-7)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335-H302-H312-H332
Precautionary statements  P261-P264-P270-P271-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501-P280-P280a-P304+P340-P305+P351+P338-P405-P501a
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-43-36-36/37/38
Safety Statements  36-36/37/39-26-24-37/39
RIDADR  2810
WGK Germany  3
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29124990
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
NFPA 704
0
2 0

2-Chloro-5-thiophenecarboxaldehyde price More Price(89)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 443239 5-Chloro-2-thiophenecarboxaldehyde 97% 7283-96-7 1g $36 2023-06-20 Buy
Sigma-Aldrich 443239 5-Chloro-2-thiophenecarboxaldehyde 97% 7283-96-7 5g $96.5 2023-06-20 Buy
TCI Chemical C1722 5-Chlorothiophene-2-carboxaldehyde >95.0%(GC) 7283-96-7 1g $24 2026-04-30 Buy
TCI Chemical C1722 5-Chlorothiophene-2-carboxaldehyde >95.0%(GC) 7283-96-7 5g $74 2026-04-30 Buy
Usbiological 436114 5-Chloro-2-thiophenecarboxaldehyde 7283-96-7 500mg $305 2026-06-03 Buy
Product number Packaging Price Buy
443239 1g $36 Buy
443239 5g $96.5 Buy
C1722 1g $24 Buy
C1722 5g $74 Buy
436114 500mg $305 Buy

2-Chloro-5-thiophenecarboxaldehyde Chemical Properties,Uses,Production

Chemical Properties

clear yellow liquid

Uses

5-Chloro-2-thiophenecarboxaldehyde is used in the evaluation of 2-benzylidene-1-tetralone derivative as antagonists of A1 and A2A adenosine receptors.

Uses

5-Chloro-2-thiophenecarboxaldehyde may be used for synthesis of 2-heteroaryl-α-methyl-5-benzoxazoleacetic acids and N,N′-bis[(E)-(5-chloro-2-thienyl)methylidene]ethane-1,2-diamine

General Description

5-Chloro-2-thiophenecarboxaldehyde is a thiophene derivative.

Synthesis

2-Chloro-5-methylthiophene

17249-82-0

2-Chloro-5-thiophenecarboxaldehyde

7283-96-7

GENERAL METHOD: 2-chloro-5-methylthiophene (200 mmol) was dissolved in anhydrous DMF (43.86 g, 600 mmol) under anhydrous conditions, cooled in an ice-water bath and stirred. POCl3 (46.00 g, 300 mmol) was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was continued to be stirred at the temperature of the ice-water bath for 30 min, and then warmed up to 100 °C for 5 h. The reaction was carried out at the temperature of the ice-water bath. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into ice water (300 mL). The aqueous phase was extracted with dichloromethane (300 mL × 3) and the organic phase was combined. The organic phase was washed sequentially with 5% brine (200 mL), 10% aqueous K2CO3 (200 mL), and 5% brine (200 mL), and then dried with anhydrous Na2SO4. The solvent was evaporated under reduced pressure to obtain the crude product. Purification of the crude product by column chromatography afforded the target compound 5-chlorothiophene-2-carbaldehyde (10ha): a colorless oil in 22.00 g (75%) yield.1H-NMR (DMSO-d6, 400 MHz) δ: 9.82 (s, 1H), 7.95 (d, J = 4.0 Hz, 1H), 7.39 (d, J = 4.0 Hz, 1H). The obtained 1H-NMR data are in agreement with literature reports [53].

References

[1] Molecules, 2018, vol. 23, # 2,
[2] Journal of the American Chemical Society, 1953, vol. 75, p. 988

2-Chloro-5-thiophenecarboxaldehyde Preparation Products And Raw materials

Raw materials

2-Chlorothiophene N,N-Dimethylformamide Phosphorus oxitrichloride N-Methylformanilide 2-Thiophenemethanol
2-Chloro-5-methylthiophene trichlorophosphate

1of2

Preparation Products

5-Methylthiophene-2-carboxaldehyde 3-(5-chlorothiophen-2-yl)acrylic acid 5-cyclopropyl-2-thiophenecarboxaldehyde tert-Butyl N-[(5-formylthiophen-2-yl)methyl]carbamate

2-Chloro-5-thiophenecarboxaldehyde Suppliers

Global( 315)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan zhijingcheng Pharmaceutical Technology Co.，Ltd 13871097899 chemistry888@126.com China 71 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
New Energy Chemicals 0515-82159099 13770142076 info@njuchem.com China 251 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Wuhan zhijingcheng Pharmaceutical Technology Co.，Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
New Energy Chemicals 65
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

View Lastest Price from 2-Chloro-5-thiophenecarboxaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Rivaroxaban Impurity 91 pictures 2026-03-12 Rivaroxaban Impurity 91
7283-96-7
 10mg 98% 500mg ShenZhen H&D Pharmaceutical Technology Co., LTD
2-Chloro-5-thiophenecarboxaldehyde pictures 2026-02-02 2-Chloro-5-thiophenecarboxaldehyde
7283-96-7
 1kg 99% 2000tons Shaanxi Dideu Medichem Co. Ltd
2-Chloro-5-thiophenecarboxaldehyde pictures 2025-04-04 2-Chloro-5-thiophenecarboxaldehyde
7283-96-7
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

2-Chloro-5-thiophenecarboxaldehyde Spectrum

2-Chloro-5-thiophenecarboxaldehyde(7283-96-7)1HNMR2-Chloro-5-thiophenecarboxaldehyde(7283-96-7)IR

7283-96-7(2-Chloro-5-thiophenecarboxaldehyde)Related Search:

Rivaroxaban Impurity 48 Rivaroxaban Impurity 44 (S)-2-(3-chloro-2-hydroxypropyl)isoindoline-1,3-dione 2-Thiophenecarboxylic acid Rivaroxaban Impurity 38
AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- Rivaroxaban iMpurity 5 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Rivaroxaban Impurity 43 Rivaroxaban Impurity 34
5-Chloro-2-thiophenecarboxylic Acid Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- Rivaroxaban Impurity 52 Rivaroxaban Impurity 41 Rivaroxaban Impurity 45
(S)-2-(2-(5-chloro-N-(4-(5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)thiophene-2-carboxamido)ethoxy)acetic acid Rivaroxaban Impurity 53 4-(4-Aminophenyl)morpholin-3-one

1of4

5-CHLOROTHIOPHENE-2-CARBALDEHYDE 5-CHLOROTHIOPHENE-2-CARBOXALDEHYDE 5-CHLORO-2-THIOPHENECARBALDEHYDE 5-CHLORO-2-THIOPHENECARBOXALDEHYDE 5-CHLORO-2-FORMYLTHIOPHENE 2-CHLORO-5-FORMYLTHIOPHENE 2-CHLOROTHIOPHENE-5-CARBOXALDEHYDE 2-CHLORO-5-THIOPHENECARBOXALDEHYDE BUTTPARK 29\08-47 TIMTEC-BB SBB004100 2-Chloro-5-thiophenecarboxalde 5-CHLORO-2-THIOPHENECARBOXALDEHYDE,97% 5-Chloro-2-thiophenaldehyde 5-chloro-2-thiophenecarboxaldehyd 5-Chlorothiophene-2-aldehyde 5-Chlorothiophene-2-carboxaldehyde,97% 5-Chlorothiophene-2-carboxaldehyde, GC 97% 2-Chloro-5-thiophene 5-Chloro-2-thiophenecarboxaldehyde, 97% 5GR 5-Chlorothiophene-2-carba... 2-Chloro-5-formylthiophene, 5-Chloro-2-thenaldehyde Rivaroxaban Impurity 125 5-Chlorothiophene-2-carboxaldehyde > oro-2-thiophenecarboxaL 2-Thiophenecarboxaldehyde, 5-chloro- Rivaroxaban Impurity 100 Rivaroxaban Impurity RC30 Chlorothiophene Aldehyde 7283-96-7 Thiophenes Heterocyclic Building Blocks Halogenated Heterocycles Building Blocks Heterocycle-oher series Thiophene&Benzothiophene Miscellaneous CHIRAL CHEMICALS Halogenated Heterocycles Heterocyclic Building Blocks Thiophenes ThiophenesBuilding Blocks Azoles blocks Aldehydes