HEXESTROL | 84-16-2

HEXESTROL Properties

Melting point	186 °C
Boiling point	353.48°C (rough estimate)
Density	1.093
refractive index	1.4800 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	almost transparency in Methanol
form	Solid
pka	9.80±0.26(Predicted)
color	White to Almost white
Merck	14,4701
BRN	3209460
Major Application	forensics and toxicology pharmaceutical (small molecule) veterinary
InChI	InChI=1/C18H22O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,17-20H,3-4H2,1-2H3/t17-,18+
InChIKey	PBBGSZCBWVPOOL-HDICACEKNA-N
SMILES	[C@@H](C1=CC=C(O)C=C1)(CC)[C@@H](C1=CC=C(O)C=C1)CC \|&1:0,10,r\|
CAS DataBase Reference	84-16-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	10BI795R7D
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H350
Precautionary statements	P201-P202-P280-P308+P313-P405-P501
PPE	Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes	T
Risk Statements	45
Safety Statements	53-45
WGK Germany	2
RTECS	SL0560850
HS Code	2907.29.9000
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Carc. 1B
Hazardous Substances Data	84-16-2(Hazardous Substances Data)

HEXESTROL price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H7753	Hexestrol analytical standard	84-16-2	1g	$73.9	2022-05-15	Buy
Sigma-Aldrich	H7753	Hexestrol analytical standard	84-16-2	5g	$353	2022-05-15	Buy
TCI Chemical	D0494	Hexestrol >98.0%(GC)	84-16-2	1g	$45	2026-04-30	Buy
TCI Chemical	D0494	Hexestrol >98.0%(GC)	84-16-2	10g	$215	2026-04-30	Buy
Cayman Chemical	29003	Hexestrol ≥98%	84-16-2	500mg	$36	2026-04-30	Buy

Product number	Packaging	Price	Buy
H7753	1g	$73.9	Buy
H7753	5g	$353	Buy
D0494	1g	$45	Buy
D0494	10g	$215	Buy
29003	500mg	$36	Buy

HEXESTROL Chemical Properties, Uses, Production

Chemical Properties

Crystalline Solid

Originator

Estra Plex,Rowell,US,1956

Uses

Nonsteroidal synthetic estrogen

Uses

Estrogen; antineoplastic (hormonal).

Manufacturing Process

50 parts by weight of p-hydroxypropiophenone are dissolved in 200 parts by weight of a 12.5% solution of caustic soda and shaken with 350 parts by weight of 3% sodium amalgam. The sodium salt of the pinacol thereby precipitating is reacted with glacial acetic acid, whereby the free pinacol is obtained (MP 205°C to 210°C, after purification 215°C to 217°C). The yield amounts to 95% of the theoretical. The pinacol is suspended in ether and gaseous hydrogen chloride introduced, whereby water separates and the pinacolin formed is dissolved in the ether, from which it is obtained by evaporation as a viscous oil (diacetate of MP 91°C). The yield is quantitative.
40 parts by weight of pinacolin are dissolved in ethyl alcohol and gradually treated with 80 parts by weight of sodium under reflux. The solution is decomposed with water and the pinacolin alcohol formed extracted from the neutalized solution with ether. The pinacolin alcohol is a viscous oil which is characterized by a dibenzoate of MP 172°C. The yield is 95% of the theoretical.
30 parts by weight of pinacolin alcohol are dissolved in 25 parts by weight of glacial acetic acid and heated for 30 minutes to 135°C to 140°C after having added 20 parts by weight of hydroiodic acid (specific gravity = 1.94) and 5 parts by weight of red phosphorus. The whole is filtered, the solution poured into water, extracted with ether and the ether solution washed with bicarbonate. The oil remaining after distilling off the ether is taken up in chloroform, whereby hexoestrol [α,β-(p,p-dihydroxy-diphenyl)-α,β-diethylethane] crystallizes out. MP after recrystallization from benzene: 185°C. Yield: 20%.

Therapeutic Function

Estrogen

Biological Activity

The carcinogen hexestrol is a nonsteroidal synthetic estrogen. Metabolic activation of hexestrol to its quinone, which reacts with DNA to form analogous depurinating adducts, may be a primary critical event leading to oncogenic mutations and cancer initiation.

Purification Methods

Crystallise meso-Hexestero from *benzene or aqueous EtOH (m 185-188o). The meso-dibenzoyl derivative has m 236-237o. The 3RS,4RS(±)-racemate [5776-72-7] crystallises from pet ether, *C6H6/pet ether, Et2O/pet ether, or MeOH/H2O and has m 128-129o . The (±)-dibenzoyl derivative has m 123-124o . The 3R,4R(+)-isomer [26614-21-1] and 3S,4S(-)-isomer [26614-22-2] crystallise from Et2O/pet ether with m 80 -80.5o and have [] D (+) and (-) 17.7o (c 5, EtOH). Their dibenzoyl derivatives have m 116.5o .[Beilstein 6 III 5503, 6 IV 6761.] They have estrogenic activity where optically active forms are more potent and they have antineoplastic activity. [Aboul-Enein et al. Anal Profiles Drug Subst 11 347 1982, J Am Chem Soc 65 4911941.]

HEXESTROL Preparation Products And Raw materials

Raw materials

cis-Anethol Phosphorus 4'-Hydroxypropiophenone Hydriodic acid Hydrochloric acid

SODIUM MERCURY AMALGAM

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Preparation Products

HEXESTROL Suppliers

Global Suppliers ( 180)

Supplier	Tel	Email	Country	ProdList	Advantage
Improve Medical Technology(Nanxiong) Co.,Ltd	0751-3836997 13711621707	2571405487@qq.com	China	22	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
Sichuan Kulinan Technology Co., Ltd	400-1166-196 18981987031	cdhxsj@163.com	China	11674	57
Maya High Purity Chemicals	+86 (573) 82222445 (0)18006601000 452520369	sales@maya-r.com	China	11693	57
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65

Supplier	Advantage
Improve Medical Technology(Nanxiong) Co.,Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Chemsky（shanghai）International Co.,Ltd.	50
Syntechem Co.,Ltd	57
Sichuan Kulinan Technology Co., Ltd	57
Maya High Purity Chemicals	57
BOC Sciences	65

View Latest Price from HEXESTROL manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-09	Hexestrol 84-16-2		1KG	≥99.9%(HPLC)	10000KGS	Improve Medical Technology(Nanxiong) Co.,Ltd
2021-11-02	HEXESTROL 84-16-2	$1300.00	1G	USP	100KGS	Baoji Guokang Healthchem co.,ltd
2021-07-13	HEXESTROL 84-16-2	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

Hexestrol
84-16-2
$0.00
≥99.9%(HPLC)
Improve Medical Technology(Nanxiong) Co.,Ltd

HEXESTROL
84-16-2
$1300.00
USP
Baoji Guokang Healthchem co.,ltd

HEXESTROL
84-16-2
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

HEXESTROL Spectrum

HEXESTROL(84-16-2)¹HNMR

84-16-2 (HEXESTROL) Related Search:

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Hexanoestrol Solution, 100ppm Hexestrol solution,100ppm Hexoestrol Hexestrol(Bibenzyl) 4,4'-(hexane-3,4-diyl)diphenol Phenol,4,4'-[(1R,2S)-1,2-diethyl-1,2-ethanediyl]bis-, rel- 4,4’-(1,2-diethyl-1,2-ethanediyl)bis-,(r*,s*)-pheno 4,4’-(1,2-diethyl-1,2-ethanediyl)bis-phenol 4,4’-(1,2-diethyl-1,2-ethylenediyl)bis-,(r*,s*)-pheno 4,4’-dihydroxy-alpha,beta-diethyldiphenylethane 4,4’-dihydroxy-gamma,delta-diphenylhexane 4,4'-Dihydroxy-alpha,beta-diethyldiphenylethane 4,4'-Dihydroxy-gamma,delta-diphenylhexane 4’-(1,2-diethylethylene)di-meso-pheno alpha,alpha’-diethyl-4,4’-dihydroxy-bibenzy 3,4-bis(p-hydroxyphenyl)-hexan 4,4'-(1,2-DIETHYLETHYLENE)DIPHENOL MESO-3,4-BIS[4-HYDROXYPHENYL]-HEXANE DIHYDRODIETHYLSTILBESTROL HEXOESTROLUM (R*,S*)-4,4'-(1,2-diethylethylene)bis(phenol) HEXESTEROL VETRANAL, 250 MG DL-HEXESTROL MESO-HEXOESTROL 4,4''-(1,2-DIETHYLETHYLENE)DIPHENOL 98+% rel-4,4'-[(1R,2S)-1,2-Diethyl-1,2-ethanediyl]bisphenol 4,4μ-(1,2-Diethylethylene)diphenol, meso-3,4-Bis(4-hydroxyphenyl)hexane, Dihydrodiethylstilbestrol [CH(C2H5)C6H4OH]2 2-(1-hydroxycyclohexyl)acetic acid butyl ester 3,4-BIS-(P-HYDROXYPHENYL)-HEXANE 3,4-DI(P-HYDROXYPHENYL)HEXANE alpha,alpha’-diethyl-4,4’dihydroxy-bibenzy Bibenzyl, alpha,alpha'-diethyl-4,4'-dihydroxy- Cycloestrol dihydro-stilbestro Dihydrostilbestrol Estra-Plex Estrifar Estronal Extra-Plex gamma,delta-Di(p-hydroxyphenyl)-hexane Hexane, 3,4-bis(p-hydroxyphenyl)- Hexanoestrol Hexestrofen Hexron Hormoestrol meso-3,4-Bis(p-hydroxyphenyl)-n-hexane meso-3,4-Di(p-hydroxyphenyl)-n-hexane meso-Hexestrol NSC-9894 Phenol, 4,4'-(1,2-diethyl-1,2-ethanediyl)bis-, (R*,S*)- Phenol, 4,4'-(1,2-diethyl-1,2-ethylenediyl)bis-, (R*,S*)- Phenol, 4,4'-(1,2-diethylethylene)di- Phenol, 4,4'-(1,2-diethylethylene)di-, meso- Sinestrol Stilbestrol, dihydro- Synestrol Synoestrol