Meptazinol
- CAS No.
- 54340-58-8
- Chemical Name:
- Meptazinol
- Synonyms
- Meptalol;MeptaMizol;MEPTAZINOL;Meptazinol A;Meptazinol-13C-d3;Meptazinol USP/EP/BP;MEPTAZINOL 54340-58-8;3-(3-ethyl-1-Methylazepan-3-yl)phenol;3-(1-Methyl-3-ethylhexahydro-1H-azepine-3-yl)phenol;3-(3-ethylhexahydro-1-methyl-1h-azepin-3-yl)-phenol
- CBNumber:
- CB8841562
- Molecular Formula:
- C15H23NO
- Molecular Weight:
- 233.35
- MDL Number:
- MFCD00864339
- MOL File:
- 54340-58-8.mol
| Melting point | 127-133°C |
|---|---|
| Boiling point | 354.8±35.0 °C(Predicted) |
| Density | 0.997 |
| pka | 9.95±0.10(Predicted) |
| FDA UNII | 18Y7S5JKZD |
| ATC code | N02AX05 |
Meptazinol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0008709 | MEPTAZINOL 95.00% | 54340-58-8 | 1MG | $460 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008709 | MEPTAZINOL 95.00% | 54340-58-8 | 5MG | $518 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008709 | MEPTAZINOL 95.00% | 54340-58-8 | 10MG | $574 | 2021-12-16 | Buy |
| Chemenu | CM200523 | 3-(3-ethyl-1-methylazepan-3-yl)phenol 97% | 54340-58-8 | 5g | $505 | 2021-12-16 | Buy |
Meptazinol Chemical Properties, Uses, Production
Originator
Meptid,Wyeth,UK,1983
Uses
Analgesic.
Definition
ChEBI: 3-(3-ethyl-1-methyl-3-azepanyl)phenol is a member of azepanes.
Manufacturing Process
2-(m-Methoxyphenyl)butyronitrile in dry ether was added to a stirred suspension of sodium amide in liquid ammonia. The mixture was stirred for 30 minutes then ethyl-4-iodobutyrate (99.25 g, 0.4 mol) in dry ether (200 ml) was added dropwise. The mixture was stirred at the temperature of refluxing liquid ammonia for 5 hours. Ammonium chloride (10 g) was added and the mixture allowed to warm to room temperature. Water (300 ml) was added, the organic layer separated, washed with water, 2 N sulfuric acid and water. After drying over magnesium sulfate and removing the ether, the product was distilled yielding ethyl 5-cyano-5-(mmethoxyphenyl)heptanoate.
That material was hydrogenated in cyclohexane using a Raney nickel catalyst. The product after distillation was recrystallized from ethyl acetate affording 10.0 g of 6-ethyl-(m-methoxyphenyl)hexahydro-2H-azepin-2one, MP 87°C to 88°C.
The azepinone (9.1 g) in dry tetrahydrofuran (50 ml) and ether (50 ml) was added dropwise to a stirred suspension of aluminum lithium hydride (7.5 g) in dry ether (50 ml). After heating under reflux for 3 hours the reaction mixture was worked up and distilled yielding 7.66 g of a compound which was a colorless oil, BP 108°C to 110°C/0.01 mm.
That product was then heated under reflux with 50% hydrobromic acid for 1.5
hours. The reaction mixture was evaporated to dryness and reevaporated with
three portions of propan-2-ol. The oil obtained was dissolved in propan-2-ol
and diluted with ether. 3-Ethyl-3-(m-hydroxyphenyl)hexahydro-1H-azepine
was obtained. That material in turn was reductively methylated by
hydrogenation in the presence of formaldehyde in absolute ethanol solution to
give 3-ethyl-3-(m-methoxyphenyl)-1-methylhexahydro-1H-azepine.
The methoxy group was converted to a hydroxy group by refluxing with 80%
HBr giving meptazinol hydrobromide.
Therapeutic Function
Analgesic
Clinical Use
Opioid analgesic used for moderate to severe pain
Drug interactions
Potentially hazardous interactions with other drugs
Antidepressants: possible CNS excitation or
depression with MAOIs - avoid; possible CNS
excitation or depression with moclobemide; possibly
increased sedative effects with tricyclics.
Antihistamines: increased sedative effects with
sedating antihistamines.
Antipsychotics: enhanced hypotensive and sedative
effects.
Dopaminergics: avoid with selegiline.
Nalmefene: avoid concomitant use.
Sodium oxybate: enhanced effect of sodium oxybate
- avoid
Metabolism
Meptazinol is extensively metabolised in the liver and is excreted mainly in the urine as the glucuronide conjugate. Less than 10% of a dose has been recovered from the faeces.
Meptazinol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9739 | 58 | |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shenzhen Simeiquan Biotechnology Co. Ltd | 18126413629 0755-23311925 2355327053 | abel@ycgmp.com | China | 5101 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shenzhen Sendi Biological Technology Co., Ltd. | 18124570582 TEL：0755-23574479 2355327139 | siliao02@yccreate.com | China | 6102 | 58 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9609 | 60 |
View Latest Price from Meptazinol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Meptazinol USP/EP/BP
54340-58-8
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-12-25 | Meptazinol
54340-58-8
|
1gram | 99% | 10kg | Zhejiang J&C Biological Technology Co.,Limited | ||
 |
2025-12-16 | Meptazinol Impurity
54340-58-8
|
10mg | 95%+ | 10000000 | Moxin Chemicals |
-
- Meptazinol USP/EP/BP
54340-58-8
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Meptazinol
54340-58-8
- $0.00
- 99%
- Zhejiang J&C Biological Technology Co.,Limited
-
- Meptazinol Impurity
54340-58-8
- 95%+
- Moxin Chemicals
