1-(Benzyloxycarbonyl) azetidine-3-carboxylic acid
- CAS No.
- 97628-92-7
- Chemical Name:
- 1-(Benzyloxycarbonyl) azetidine-3-carboxylic acid
- Synonyms
- 1-Cbz-azetidine-3-carboxylic acid;1-Cbz-azetidine-3-carboxy...;Cbz-3-Azetidinecarboxylic acid;CBZ-AZETIDINE-3-CARBOXYLIC ACID;N-Cbz-azetidine-3-carboxylic acid;N-Carbobenzyloxyazetidine-3-carboxylic acid;1-Cbz-azetidine-3-carboxylic acid - [C1527];1-benzyloxycarbonyl-3-azetidinecarboxylic acid;Azetidine-1,3-dicarboxylic acid 1-benzyl ester;1-(Benzyloxycarbonyl) azetidine-3-carboxylic acid
- CBNumber:
- CB8844563
- Molecular Formula:
- C12H13NO4
- Molecular Weight:
- 235.24
- MDL Number:
- MFCD09027504
- MOL File:
- 97628-92-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
1-(Benzyloxycarbonyl) azetidine-3-carboxylic acid price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-W004868 | 1-Cbz-azetidine-3-carboxylic acid ≥97% | 97628-92-7 | 5g | $15 | 2026-06-04 | Buy |
| ChemScene | CS-W004868 | 1-Cbz-azetidine-3-carboxylic acid ≥97% | 97628-92-7 | 10g | $21 | 2026-06-04 | Buy |
| ChemScene | CS-W004868 | 1-Cbz-azetidine-3-carboxylic acid ≥97% | 97628-92-7 | 25g | $41 | 2026-06-04 | Buy |
| ChemScene | CS-W004868 | 1-Cbz-azetidine-3-carboxylic acid ≥97% | 97628-92-7 | 100g | $159 | 2026-06-04 | Buy |
| Apolloscientific | OR309030 | 1-Benzyloxycarbonyl-3-azetidinecarboxylic acid >96% | 97628-92-7 | 5g | $21 | 2026-06-04 | Buy |
1-(Benzyloxycarbonyl) azetidine-3-carboxylic acid Chemical Properties, Uses, Production
Uses
1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Synthesis
36476-78-5
501-53-1
97628-92-7
General procedure for the synthesis of 1-(benzyloxycarbonyl)azetidine-3-carboxylic acid from 3-acridinecarboxylic acid and benzyl chloroformate: 3-acridinecarboxylic acid (4.0 g, 39.6 mmol) was dissolved in a 1 N sodium hydroxide solution (40 mL) and the solution was cooled to 0 °C. Under stirring, benzyl chloroformate (5.9 mL, 41 mmol) was slowly added, followed by dropwise addition of additional 1 N sodium hydroxide solution (41 mL). The reaction mixture was stirred vigorously at 0 °C for 16 hours. Upon completion of the reaction, the mixture was acidified to a pH of about 2-3 with 2 N hydrochloric acid.The acidified suspension was extracted with dichloromethane (2 x 100 mL) and the organic layers were combined and dried with anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure to afford the white solid product 1-(benzyloxycarbonyl)azetidine-3-carboxylic acid (9.3 g, 39.6 mmol, 100% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.37-7.29 (5H, m, Ar-H), 5.10 (2H, s, CH2Ph), 4.21 (4H, d, J = 7.5 Hz, NCH2), 3.43 (1H, quintuple peak, J = 7.5 Hz, CH).
IC 50
Non-cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
1-(Benzyloxycarbonyl) azetidine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Boc Chemical Co.,Ltd | 021-34975603-808 18721111801 | sales@bocpharma.com | China | 991 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
View Latest Price from 1-(Benzyloxycarbonyl) azetidine-3-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-15 | 1-(BENZYLOXYCARBONYL) AZETIDINE-3-CARBOXYLIC ACID
97628-92-7
|
$1.50 | 1g | 99.0% Min | 100 Tons | Shaanxi Didu New Materials Co. Ltd |
-
- 1-(BENZYLOXYCARBONYL) AZETIDINE-3-CARBOXYLIC ACID
97628-92-7
- $1.50
- 99.0% Min
- Shaanxi Didu New Materials Co. Ltd
