Tauroursodeoxycholic Acid-d4 (sodium salt)
- CAS No.
- 2410279-95-5
- Chemical Name:
- Tauroursodeoxycholic Acid-d4 (sodium salt)
- Synonyms
- D4-Tauroursodeoxycholic Acid Sodium Salt;Taurine ursodeoxycholic acid-d4 sodium salt;Tauroursodeoxycholic Acid-[d4] Sodium Salt in Methanol;Tauroursodeoxycholic acid, sodium salt (2,2,4,4-D?, 98%);TAUROURSODEOXYCHOLICACID,SODIUMSALT(2,2,4,4-D4) IN METHANOL;Tauroursodeoxycholic acid, sodium salt (2,2,4,4-D?, 98%) 100 μg/mL in methanol;Tauroursodeoxycholic Acid-[d4] Sodium Salt/Tauroursodeoxycholic acid-[d4] sodium
- CBNumber:
- CB88571049
- Molecular Formula:
- C26H46NNaO6S
- Molecular Weight:
- 523.7
- MDL Number:
- MOL File:
- 2410279-95-5.mol
Tauroursodeoxycholic Acid-d4 (sodium salt) Chemical Properties,Uses,Production
Description
Tauroursodeoxycholic acid-d4 (TUDCA-d4) is intended for use as an internal standard for the quantification of tauroursodeoxycholic acid by GC- or LC-MS. TUDCA is a taurine-conjugated form of the secondary bile acid ursodeoxycholic acid .1,2 TUDCA is found in small quantities in human bile but at a higher concentration in the bile of black bears.2 It demonstrates anti-apoptotic activity in rodent models of tauopathy, Huntington's disease, ischemic brain injury, and retinal disorders.3,2
Uses
Tauroursodeoxycholate-d4 (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
References
1. Beuers, U. Effects of bile acids on hepatocellular signaling and secretion Yale J. Biol. Med. 70(4),341-346(1997).
2. Boatright, J.H., Nickerson, J.M., Moring, A.G., et al. Bile acids in treatment of ocular disease J. Ocul. Biol. Dis. Infor. 2(3),149-159(2009).
3. Vang, S., Longley, K., Steer, C.J., et al. The unexpected uses of urso-
Tauroursodeoxycholic Acid-d4 (sodium salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Tauroursodeoxycholic Acid-d4 (sodium salt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Artis Biotech Co. Ltd. | 19138486554 18582380095 | sales@artisbio.com | China | 1910 | 58 |
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6973 | 58 |
| PureChemland Co.,Ltd. | 13540909846 13882008651 | 3848291069@qq.com | China | 3001 | 58 |
| Reer Technology (Shanghai) Co., LTD | 021-64400900 15800436310 | bessey@reertech.com | China | 4105 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| SHANGHAI ZZBIO CO., LTD. | 15102117276 19921389125 | tech@zzbioco.com | China | 12064 | 58 |
| Tanmo Quality Inspection Technology Co., Ltd. | 4008-099-669 | 23419001name@qq.com | CHINA | 6043 | 58 |
| BePure (Beijing) Biotechnology Co. | 58896805 | 7993601name@qq.com | CHINA | 6620 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 13308200041 | 2851167782@qq.com | China | 11146 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
