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methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate

methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate Structure
methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate structure
CAS No.
1601-18-9
Chemical Name:
methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate
Synonyms
Indomethacin Methyl Ester;L 588983;Indometacin Impurity H;Indapamide EP Impurity H;Indometacin EP Impurity H;Indomethacin EP Impurity H;Methyl 2-(1-(4-chlorobenzoyl);Methyl [1-(4-Chlorobenzoyl)-5-metho;Indomethacin Impurity 8(Indomethacin EP Impurity H);Methyl N-(p-Chlorobenzoyl)-2-Methyl-5-Methoxy-3-indolylacetate
CBNumber:
CB8912958
Molecular Formula:
C20H18ClNO4
Molecular Weight:
371.81
MDL Number:
MFCD01719291
MOL File:
1601-18-9.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:40
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methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate Properties

Melting point 99-100 °C
Boiling point 463.4±45.0 °C(Predicted)
Density 1.26±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
form Solid
color Pale Yellow to Light Green
FDA UNII V7N8G32K46
NIST Chemistry Reference Indomethacin, methyl ester(1601-18-9)

methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 280435 Indomethacin methyl ester 1601-18-9 5mg $403 2026-06-03 Buy
Usbiological 280435 Indomethacin methyl ester 1601-18-9 10mg $602 2026-06-03 Buy
Usbiological 280435 Indomethacin methyl ester 1601-18-9 25mg $904 2026-06-03 Buy
Usbiological 280435 Indomethacin methyl ester 1601-18-9 50mg $1396 2026-06-03 Buy
Usbiological 280435 Indomethacin methyl ester 1601-18-9 100mg $2232 2026-06-03 Buy
Product number Packaging Price Buy
280435 5mg $403 Buy
280435 10mg $602 Buy
280435 25mg $904 Buy
280435 50mg $1396 Buy
280435 100mg $2232 Buy

methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate Chemical Properties, Uses, Production

Chemical Properties

Pale Green Solid

Uses

Selective COX-2 inhibitor

Synthesis

Methanol

67-56-1

Indometacin

53-86-1

methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate

1601-18-9

GENERAL METHOD: 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid (1 eq.) and BOP-Cl (1 eq.) were suspended in dichloromethane (20 mL/g of acid), triethylamine (2 eq.) was added slowly and the mixture was stirred for 10 minutes. Methanol (4 eq.) was then added and the reaction mixture continued to be stirred for at least 12 hours. Upon completion of the reaction, the solvent was removed by evaporation and the resulting solid was purified by column chromatography with the eluent being a solvent mixture of hexane and ethyl acetate (3:1, v/v) at a boiling range of 80-100°C. Finally, the solvent was removed under reduced pressure to give methyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate as a light yellow solid.

References

[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 15, p. 4830 - 4837
[2] Pharmazie, 2003, vol. 58, # 2, p. 99 - 103
[3] Patent: CN105418480, 2016, A. Location in patent: Paragraph 0031
[4] Bioorganic and Medicinal Chemistry, 2001, vol. 9, # 3, p. 745 - 762
[5] European Journal of Pharmaceutical Sciences, 2001, vol. 14, # 4, p. 301 - 311

methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate Preparation Products And Raw materials

Raw materials

Methanol Indometacin Dichloromethane Triethylamine

Preparation Products

methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate Suppliers

Global Suppliers ( 82)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412 3001272453@qq.com China 5000 50
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Taian Jiaye Biotechnology Co.Ltd 15318151873;13127280945 285424065@qq.com China 9961 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Chemsky（shanghai）International Co.,Ltd. 50
BOC Sciences 65
S.Z. PhyStandard Bio-Tech. Co., Ltd. 50
Hangzhou Sage Chemical Co., Ltd. 58
Bide Pharmatech Ltd. 60
Quality Control Solutions Ltd. 56
BOC Sciences 65
Amadis Chemical Company Limited 58
Taian Jiaye Biotechnology Co.Ltd 55

View Latest Price from methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate pictures 2024-10-22 methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate
1601-18-9
 1KG 95%-99% 1kg; 5kg; 10kg Career Henan Chemica Co

1601-18-9 (methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate) Related Search:

5-Methoxy-2-methyl-3-indoleacetic acid Methanone, (4-chlorophenyl)[2,6-dichloro-4-(hydroxymethyl)phenyl]- Indometacin Impurity 17 Indometacin Impurity 16 Indomethacin-d4
Indometacin 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-, ethyl ester 4-Chloro-2-(4-chlorobenzoyl)-1-(4-Methoxyphenyl)hydrazide Benzoic Acid 4-Chloro-N-(4-Methoxyphenyl)benzaMide, 97% IndoMethacin DiaMide
4-Chlorobenzoic acid Indometacin EP Impurity G 1H-Indole-3-aceticacid,1-(3-chlorobenzoyl)-5-methoxy-2-methyl 2-(4-Methoxyphenyl)hydrazinesulfonic acid sodium salt monohydrate Benzoic acid, 4-chloro-, 2,3-dihydroxypropyl ester
1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-hydroxypropyl ester 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-,2,3-d ihydroxypropyl ester Indometacin Impurity 18

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methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate [1-(4-Chlorobenzoyl)-2-methyl-5-methoxy-1H-indole-3-yl]acetic acid methyl ester 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid methyl ester 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetic acid methyl ester methyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate methyl 2-[1-(4-chlorophenyl)carbonyl-5-methoxy-2-methyl-indol-3-yl]ethanoate 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-, Methyl ester L 588983 Methyl N-(p-Chlorobenzoyl)-2-Methyl-5-Methoxy-3-indolylacetate Methyl 2-(1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-1H-indol-3-yl)acetate Methyl 2-(1-(4-chlorobenzoyl) Indometacin EP Impurity H Indomethacin Impurity 8(Indomethacin EP Impurity H) Indomethacin impurity 7/Indomethacin EP Impurity H/methyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate Indomethacin EP Impurity H Indapamide EP Impurity H Methyl [1-(4-Chlorobenzoyl)-5-metho Methyl [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate Indometacin Impurity H Indomethacin (Indometacin) EP Impurity H (Indomethacin Methyl Ester) Methyl 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl]acetate Methyl [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate (Indomethacin Methyl Ester) Indometacin Imp.H (EP): methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-ylacetate Indomethacin Methyl Ester 1601-18-9 Aromatics Indole Derivatives Inhibitors Intermediates & Fine Chemicals Pharmaceuticals