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3-chloro-4-nitrophenol

3-chloro-4-nitrophenol Structure
3-chloro-4-nitrophenol structure
CAS No.
491-11-2
Chemical Name:
3-chloro-4-nitrophenol
Synonyms
3-Chlor-4-nitrophenol;Lenvatinib Impurity 44;Phenol, 3-chloro-4-nitro-;2-Chloro-4-hydroxynitrobenzene;3-chloro-4-nitrophenol CAS NO.491-11-2
CBNumber:
CB8934842
Molecular Formula:
C6H4ClNO3
Molecular Weight:
173.55
MDL Number:
MFCD00466090
MOL File:
491-11-2.mol
MSDS File:
SDS
Last updated:2026-05-28 03:50:46
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3-chloro-4-nitrophenol Properties

Melting point 120-121℃
Boiling point 330.5±27.0 °C(Predicted)
Density 1.554
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka 6.32±0.10(Predicted)
form Solid
color Pale Yellow to Light Beige
EPA Substance Registry System Phenol, 3-chloro-4-nitro- (491-11-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H315-H302-H335
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HS Code  2908990000

3-chloro-4-nitrophenol price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-C350275-500MG 3-Chloro-4-nitrophenol 491-11-2 500mg $84 2026-06-03 Buy
TRC TRC-C350275-250MG 3-Chloro-4-nitrophenol 491-11-2 250mg $59 2026-06-03 Buy
TRC TRC-C350275-1G 3-Chloro-4-nitrophenol 491-11-2 1g $109 2026-06-03 Buy
Biosynth FC140090 3-Chloro-4-nitrophenol 491-11-2 1g $183.44 2026-06-04 Buy
Biosynth FC140090 3-Chloro-4-nitrophenol 491-11-2 2g $293.48 2026-06-04 Buy
Product number Packaging Price Buy
TRC-C350275-500MG 500mg $84 Buy
TRC-C350275-250MG 250mg $59 Buy
TRC-C350275-1G 1g $109 Buy
FC140090 1g $183.44 Buy
FC140090 2g $293.48 Buy

3-chloro-4-nitrophenol Chemical Properties, Uses, Production

Uses

3-Chloro-4-nitrophenol was used as a reactant in the synthetic preparation of highly potent BTK and JAK3 dual inhibitors and it may also have antifungal activity.

Synthesis

3-Chlorophenol

108-43-0

3-chloro-4-nitrophenol

491-11-2

GENERAL METHOD: A suspension of 3-chlorophenol (18.5 mmol, 1.0 eq.) and Cu(NO3)2-3H2O (27.7 mmol, 1.5 eq.) in THF was formed by magnetic stirring or refluxing for several hours at 60 °C. The reaction was carried out under reduced pressure and the solvent was extracted with ethyl acetate (3 x 30 mL). Upon completion of the reaction, the solvent was removed under reduced pressure and the mixture was subsequently extracted with ethyl acetate (3 × 30 mL). The organic phases were combined, washed with saturated saline (5 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography to afford the target compound 3-chloro-4-nitrophenol in 67-90% yield.

References

[1] Journal of Chemical Sciences, 2011, vol. 123, # 1, p. 63 - 67
[2] Arkivoc, 2014, vol. 2014, # 5, p. 64 - 71
[3] Research on Chemical Intermediates, 2018, vol. 44, # 10, p. 6023 - 6038
[4] International Journal of Chemical Kinetics, 2017, vol. 49, # 8, p. 622 - 632
[5] Helvetica Chimica Acta, 1963, vol. 46, p. 727 - 741

3-chloro-4-nitrophenol Preparation Products And Raw materials

Raw materials

3-Chlorophenol 2-Chloro-4-methoxynitrobenzene Tetrahydrofuran Cupric nitrate trihydrate

Preparation Products

Chlorthion tert-Butyl(3-chloro-4-nitrophenoxy)dimethylsilane

3-chloro-4-nitrophenol Suppliers

Global Suppliers ( 116)
Supplier Tel Email Country ProdList Advantage
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 28-83379370 13880556291 tcy@tcypharm.com China 509 57
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chembon Pharmaceutical Co., Ltd. 028-84252981 18583719936 sales@chembon.com.cn China 854 64
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
SuZhou ShiYa Biopharmaceuticals, Inc. 86(512)5235 8471 17715136450 sales@shiyabiopharm.com China 4167 58
Shanghai JONLN Reagent Co., Ltd. 400-0066400 13621662912 422131432@qq.com China 9970 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
Tianjin Anhao Biological Technology Co., Ltd. sales@ahpharmatech.com China 5734 55
Supplier Advantage
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 57
Adamas Reagent, Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Chembon Pharmaceutical Co., Ltd. 64
Shanghai Topbiochem Technology Co., Ltd 58
SuZhou ShiYa Biopharmaceuticals, Inc. 58
Shanghai JONLN Reagent Co., Ltd. 55
Bide Pharmatech Ltd. 60
Quality Control Solutions Ltd. 56
Tianjin Anhao Biological Technology Co., Ltd. 55

View Latest Price from 3-chloro-4-nitrophenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Chloro-4-nitrophenol pictures 2026-08-25 3-Chloro-4-nitrophenol
491-11-2
 $2.00-5.00 99% ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
3-chloro-4-nitrophenol pictures 2022-02-19 3-chloro-4-nitrophenol
491-11-2
 1KG 98.4% 100 tons Honest Joy Holdings Limited
3-chloro-4-nitrophenol pictures 2019-07-14 3-chloro-4-nitrophenol
491-11-2
 $1.00 1KG 99% 100kg Career Henan Chemical Co

3-chloro-4-nitrophenol Spectrum

3-chloro-4-nitrophenol(491-11-2)1HNMR

491-11-2 (3-chloro-4-nitrophenol) Related Search:

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Phenol, 3-chloro-4-nitro- 2-Chloro-4-hydroxynitrobenzene 3-Chlor-4-nitrophenol 3-chloro-4-nitrophenol CAS NO.491-11-2 Lenvatinib Impurity 44 491-11-2