N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide
![N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide Structure](CAS/20210305/GIF/2409140-12-9.gif)
- CAS No.
- 2409140-12-9
- Chemical Name:
- N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide
- Synonyms
- HRX-0233;N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide;1-Propanesulfonamide, N-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,6-difluorophenyl]-
- CBNumber:
- CB89382536
- Molecular Formula:
- C24H21F2N5O3S
- Molecular Weight:
- 497.52
- MDL Number:
- MOL File:
- 2409140-12-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| HRX-0233 98.92% | CS-1174532 | 5mg | $379 |
| HRX-0233 98.92% | CS-1174532 | 10mg | $617 |
| HRX-0233 98.92% | CS-1174532 | 25mg | $1246 |
| HRX-0233 98.92% | CS-1174532 | 50mg | $1993 |
| HRX-0233 98.92% | CS-1174532 | 100mg | $3196 |
N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1174532 | HRX-0233 98.92% | 2409140-12-9 | 5mg | $379 | 2026-06-04 | Buy |
| ChemScene | CS-1174532 | HRX-0233 98.92% | 2409140-12-9 | 10mg | $617 | 2026-06-04 | Buy |
| ChemScene | CS-1174532 | HRX-0233 98.92% | 2409140-12-9 | 25mg | $1246 | 2026-06-04 | Buy |
| ChemScene | CS-1174532 | HRX-0233 98.92% | 2409140-12-9 | 50mg | $1993 | 2026-06-04 | Buy |
| ChemScene | CS-1174532 | HRX-0233 98.92% | 2409140-12-9 | 100mg | $3196 | 2026-06-04 | Buy |
N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide Chemical Properties,Uses,Production
Uses
HRX-0233 is a small-molecule MAP2K4 inhibitor. HRX-0233 results in strong tumor shrinkage without any apparent toxicity in H358 KRASG12C-mutant non-small cell lung cancers (NSCLC) in vivo. HRX-0233 efficiently prevents feedback activation of receptor tyrosine kinases (RTKs) upon monotherapy KRAS inhibitor Sotorasib (HY-114277) and causes a more sustained and complete inhibition of MAPK signaling. HRX-0233 is promising for research of AR-negative prostate cancer, lung and colon cancers[1][2].
References
[1] Jansen RA, et al. Small-molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS-mutant cancers. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2319492121. DOI:10.1073/pnas.2319492121
[2] Tipayasri P. Development of Rational Combination Therapies for Patients with Metastatic Prostate Cancer and Loss of the PTEN Tumor Suppressor Gene[D]. , 2024.
N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Rovathin Foreign Trade Co.,Ltd | 0512-65816829 18662214788 | info@rovathin.com.cn | China | 9974 | 58 |
| DC Chemicals | 021-58447131 13564518121 | doncunbiosci@gmail.com | China | 591 | 58 |
| Changzhou Borl Biotechnology Co.,LTD | 13606124132;13656121842 | luyan0021@163.com | China | 261 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29845 | 58 |
| Shenzhen Zuoke Biotechnology Co., Ltd. | 13532174601 | CHINA | 6209 | 58 | |
| Guangzhou New Century Technology Co., Ltd. | 020-13113998854 13113998854 | 1094589719@qq.com | China | 6045 | 58 |
