ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide

N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide

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N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide Suppliers list
Company Name: Suzhou Rovathin Foreign Trade Co.,Ltd  
Tel: 0512-65816829 18662214788
Email: info@rovathin.com.cn
Products Intro: Product Name:N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide
CAS:2409140-12-9
Package:100g/;1kg/
Company Name: DC Chemicals  
Tel: 021-58447131 13564518121
Email: doncunbiosci@gmail.com
Products Intro: Product Name:HRX-0233
Purity:98% HPLC Package:100mg,250mg,1g
Company Name: Changzhou Borl Biotechnology Co.,LTD  
Tel: 13606124132;13656121842
Email: luyan0021@163.com
Products Intro: Product Name:N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide
CAS:2409140-12-9
Purity:98% Package:1g
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:HRX-0233
CAS:2409140-12-9
Package:50mg/RMB 21300
Company Name: Biorbyt Ltd.  
Tel: +44 (0)1223 859 353
Email: info@biorbyt.com
Products Intro: Product Name:HRX-0233
CAS:2409140-12-9
N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide Basic information
Product Name:N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide
Synonyms:N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide;1-Propanesulfonamide, N-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,6-difluorophenyl]-;HRX-0233
CAS:2409140-12-9
MF:C24H21F2N5O3S
MW:497.52
EINECS:
Product Categories:
Mol File:2409140-12-9.mol
N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide Structure
N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide Chemical Properties
density 1.485±0.06 g/cm3(Predicted)
pka6.43±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide Usage And Synthesis
UsesHRX-0233 is a small-molecule MAP2K4 inhibitor. HRX-0233 results in strong tumor shrinkage without any apparent toxicity in H358 KRASG12C-mutant non-small cell lung cancers (NSCLC) in vivo. HRX-0233 efficiently prevents feedback activation of receptor tyrosine kinases (RTKs) upon monotherapy KRAS inhibitor Sotorasib (HY-114277) and causes a more sustained and complete inhibition of MAPK signaling. HRX-0233 is promising for research of AR-negative prostate cancer, lung and colon cancers[1][2].
References[1] Jansen RA, et al. Small-molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS-mutant cancers. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2319492121. DOI:10.1073/pnas.2319492121
[2] Tipayasri P. Development of Rational Combination Therapies for Patients with Metastatic Prostate Cancer and Loss of the PTEN Tumor Suppressor Gene[D]. , 2024.
N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide Preparation Products And Raw materials
Tag:N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,6-difluorophenyl)propane-1-sulfonamide(2409140-12-9) Related Product Information