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(R)-1-N-Boc-2-(hydroxymethyl)piperazine

(R)-1-N-Boc-2-(hydroxymethyl)piperazine structure

CAS No.: 169448-87-7

Chemical Name:: (R)-1-N-Boc-2-(hydroxymethyl)piperazine

Synonyms: tert-butyl (R)-2-(hydroxymethyl)piperazine-1-carboxylate;Nicotinamide Impurity 202;(R)-1-Boc-2-Hydroxymethyl-piperazine;(R)-1-Boc-2-(hyroxyMethyl)piperazine;(R)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE HCl;(S)-1-Boc-2-Hydroxymethyl-piperazine ,98%;(R)-1-Boc-2-Hydroxymethyl-piperazine ,98%;(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate;tert-Butyl (2R)-2-(hydroxymethyl)piperazin-1-carboxylate;tert-Butyl (2R)-2-(hydroxymethyl)piperazine-1-carboxylate

CBNumber:: CB8948025

Molecular Formula:: C10H20N2O3

Molecular Weight:: 216.28

MDL Number:: MFCD07772092

MOL File:: 169448-87-7.mol

MSDS File:: SDS

Last updated:2026-05-28 03:59:17

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(R)-1-N-Boc-2-(hydroxymethyl)piperazine Properties

Boiling point	324.0±17.0 °C(Predicted)
Density	1.085±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
pka	14.97±0.10(Predicted)
Appearance	White to off-white Solid
optical activity	Consistent with structure
InChI	InChI=1S/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-6-8(12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1
InChIKey	BCPPNDHZUPIXJM-MRVPVSSYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCNC[C@@H]1CO

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
HS Code	2933599590

(R)-1-N-Boc-2-(hydroxymethyl)piperazine price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	56773	(R)-1-BOC-2-HYDROXYMETHYLPIPERAZINE 97%	169448-87-7	0.25G	$93	2026-04-30	Buy
AstaTech	56773	(R)-1-BOC-2-HYDROXYMETHYLPIPERAZINE 97%	169448-87-7	1G	$277	2026-04-30	Buy
AstaTech	56773	(R)-1-BOC-2-HYDROXYMETHYLPIPERAZINE 97%	169448-87-7	5G	$997	2026-04-30	Buy
Apolloscientific	OR308074	tert-Butyl (2R)-2-(hydroxymethyl)piperazine-1-carboxylate 97%	169448-87-7	100mg	$21	2026-06-04	Buy
Apolloscientific	OR308074	tert-Butyl (2R)-2-(hydroxymethyl)piperazine-1-carboxylate 97%	169448-87-7	250mg	$24	2026-06-04	Buy

Product number	Packaging	Price	Buy
56773	0.25G	$93	Buy
56773	1G	$277	Buy
56773	5G	$997	Buy
OR308074	100mg	$21	Buy
OR308074	250mg	$24	Buy

(R)-1-N-Boc-2-(hydroxymethyl)piperazine Chemical Properties,Uses,Production

Uses

(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate is used in preparation of novel substituted quinoline-8-carbonitrile derivatives with androgen receptor degradation activity and uses thereof.

Synthesis

Lithium aluminum hydride (1M in THF, 26 ml) was added to a solution of L-TERT- butyl 2-methyl (2R)-piperazine-1, 2-dicarboxylate (2. 55 g) in THF (70 ml) at-40°C, and then the reaction was warmed to room temperature. After stirring for 1 h, this reaction system was cooled to 0°C and quenched by sequential addition of water (1 ml), sodium hydroxide (2N, 1 ml), and then water (2 ml). The resulting slurry was filtered and concentrated in vacuo to give (R)-1-N-Boc-2-(hydroxymethyl)piperazine.

References

[1] Patent: WO2005/26152, 2005, A1. Location in patent: Page/Page column 136

(R)-1-N-Boc-2-(hydroxymethyl)piperazine synthesis

Synthesis of (R)-1-N-Boc-2-(hydroxymethyl)piperazine from (R)-N-Boc-piperazine-2-carboxylic acid methyl ester

(R)-1-N-Boc-2-(hydroxymethyl)piperazine Preparation Products And Raw materials

Raw materials

(R)-N-Boc-piperazine-2-carboxylic acid methyl ester Tetrahydrofuran Lithium Aluminum Hydride

Preparation Products

(R)-1-N-Boc-2-(hydroxymethyl)piperazine Suppliers

Global( 135)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Pharmavoyager	15351203386	2592141051@qq.com	China	93	55
ForeChem (Nantong) Technology Co.,Ltd.	513-85982855 18921614129	sales@xianxingpharm.com	China	2712	61
Chengdu Firster Pharmaceutical Co., Ltd.	19138996873	670603485@qq.com	China	196	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Sichuan Guanghan Bio-Tech Co., Ltd	+86-28-86127071	info@sino-produce.com	China	400	66
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Boc Chemical Co.,Ltd	021-34975603-808 18721111801	sales@bocpharma.com	China	991	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66

Supplier	Advantage
Pharmavoyager	55
ForeChem (Nantong) Technology Co.,Ltd.	61
Chengdu Firster Pharmaceutical Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Sichuan Guanghan Bio-Tech Co., Ltd	66
Adamas Reagent, Ltd.	59
Accela ChemBio Co.,Ltd.	64
Shanghai Boc Chemical Co.,Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
China DongFan Chemical Co.,LTD	66

View Lastest Price from (R)-1-N-Boc-2-(hydroxymethyl)piperazine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-27	(R)-1-N-Boc-2-(hydroxymethyl)piperazine 169448-87-7	$6.60	1KG	97%-99%	1kg-1000kg	Career Henan Chemical Co

(R)-1-N-Boc-2-(hydroxymethyl)piperazine
169448-87-7
$6.60
97%-99%
Career Henan Chemical Co

(R)-1-N-Boc-2-(hydroxymethyl)piperazine Spectrum

(R)-1-N-Boc-2-(hydroxymethyl)piperazine(169448-87-7)¹HNMR

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(R)-1-Boc-2-Hydroxymethyl-piperazine 1-Piperazinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2R)- (R)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE HCl 2-Methyl-2-propanyl(2R)-2-(hydroxymethyl)-1-piperazinecarboxylate (R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate (R)-1-Boc-2-Hydroxymethyl-piperazine ,98% (S)-1-Boc-2-Hydroxymethyl-piperazine ,98% tert-Butyl (2R)-2-(hydroxymethyl)piperazine-1-carboxylate (R)-1-Boc-2-(hyroxyMethyl)piperazine (R)-1-N-Boc-2-(hydroxymethyl)piperazine###(R)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (2R)-2-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester tert-Butyl (2R)-2-(hydroxymethyl)piperazin-1-carboxylate Nicotinamide Impurity 202 tert-butyl (R)-2-(hydroxymethyl)piperazine-1-carboxylate 169448-87-7 16944-87-7 169448-87-8 Piperaizine