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(R)-1-BOC-3-(Hydroxymethyl)piperazine

(R)-1-BOC-3-(Hydroxymethyl)piperazine structure

CAS No.: 278788-66-2

Chemical Name:: (R)-1-BOC-3-(Hydroxymethyl)piperazine

Synonyms: tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate;(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate;H57159;(3R)-3-(hydroxymethyL;PIPERAZINE-1-CARBOXYLIC;(R)-4-N-Boc-2-hydroxyMeth...;(3R)-3-(Hydroxymethyl)piperazine;(R)-4-Boc-2-hydroxymethyl-piperazine

CBNumber:: CB9715509

Molecular Formula:: C10H20N2O3

Molecular Weight:: 216.28

MDL Number:: MFCD05863888

MOL File:: 278788-66-2.mol

MSDS File:: SDS

Last updated:2026-06-04 16:00:12

Product description	Number	Pack Size	Price
(R)-1-BOC-3-(Hydroxymethyl)piperazine	SYX00408	1g	$506
(R)-1-Boc-3-hydroxymethylpiperazine	TRC-B662275-1G	1g	$80
(R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE 97%	58754	1G	$68
(R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE 97%	58754	5G	$205
(R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE 97%	58754	25G	$680
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(R)-1-BOC-3-(Hydroxymethyl)piperazine Properties

Melting point	68-70°C
Boiling point	322.9±22.0 °C(Predicted)
Density	1.085±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	14.97±0.10(Predicted)
color	White to Off-White
optical activity	Consistent with structure
InChI	InChI=1S/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1
InChIKey	NSILYQWHARROMG-MRVPVSSYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCN[C@@H](CO)C1
CAS DataBase Reference	278788-66-2(CAS DataBase Reference)
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301+H311+H331-H315-H319
Precautionary statements	P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405
Hazard Codes	Xi
Risk Statements	41-52
Safety Statements	26-39
RIDADR	UN3259
HazardClass	8
HS Code	2933599590
Storage Class	11 - Combustible Solids
Limited Quantities	5.0 kg (11 lbs) (solid)
Excepted Quantities	Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

(R)-1-BOC-3-(Hydroxymethyl)piperazine price More Price(76)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SYX00408	(R)-1-BOC-3-(Hydroxymethyl)piperazine	278788-66-2	1g	$506	2026-04-30	Buy
TRC	TRC-B662275-1G	(R)-1-Boc-3-hydroxymethylpiperazine	278788-66-2	1g	$80	2026-06-03	Buy
AstaTech	58754	(R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE 97%	278788-66-2	1G	$68	2026-04-30	Buy
AstaTech	58754	(R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE 97%	278788-66-2	5G	$205	2026-04-30	Buy
AstaTech	58754	(R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE 97%	278788-66-2	25G	$680	2026-04-30	Buy

Product number	Packaging	Price	Buy
SYX00408	1g	$506	Buy
TRC-B662275-1G	1g	$80	Buy
58754	1G	$68	Buy
58754	5G	$205	Buy
58754	25G	$680	Buy

(R)-1-BOC-3-(Hydroxymethyl)piperazine Chemical Properties,Uses,Production

Uses

(R)-1-Boc-3-hydroxymethylpiperazine is a used as a building block for the preparation of PI3K inhibitors for rheumatoid arthritis treatment,benzoxaborole derivatives as antimalarial agents and anti-tuberculosis agents.

Synthesis

1,4-bis-Boc-2-hydroxymethylpiperazine (13.9 kg) and 95% ethanol (30 kg) were added to the reactor, followed by the addition of an aqueous solution (water 21 kg) of configured sodium hydroxide (3.5 kg). The reaction mixture was then heated to reflux. Once the reaction was completed, ethanol was concentrated under reduced pressure. Subsequently, 30 kg of dichloromethane was added and the mixture was separated into liquid and aqueous phases. The aqueous phase was extracted three times with 3 × 20 kg of dichloromethane, and the organic phases were combined. The resulting solution was washed once with 40 kg of a 15% aqueous sodium chloride solution and dried with anhydrous sodium sulfate. Further purification was carried out to obtain (R)-1-BOC-3-(Hydroxymethyl)piperazine.

References

[1] Patent: EP1140904, 2005, B1. Location in patent: Page/Page column 35

(R)-1-BOC-3-(Hydroxymethyl)piperazine synthesis

Synthesis of (R)-1-BOC-3-(Hydroxymethyl)piperazine from (R)-1,4-(DI-BOC)-2-(HYDROXYMETHYL)PIPERAZINE

(R)-1-BOC-3-(Hydroxymethyl)piperazine Preparation Products And Raw materials

Raw materials

3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxylic acid, tetrahydro-1,3-dioxo-, 1,1-dimethylethyl ester, (8aR)- (R)-1,4-(DI-BOC)-2-(HYDROXYMETHYL)PIPERAZINE Ethanol Sodium borohydride

Preparation Products

(R)-1-BOC-3-(Hydroxymethyl)piperazine Suppliers

Global( 255)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boc Chemical Co., Ltd.	021-34975602; +8618721111801	shangli@bocchem.com	China	138	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58

Supplier	Advantage
Shanghai Boc Chemical Co., Ltd.	58
Labnetwork lnc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from (R)-1-BOC-3-(Hydroxymethyl)piperazine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-06	(R)-1-BOC-3-(Hydroxymethyl)piperazine 278788-66-2	$98.00-990.00	5g	98%	50	Zibo Hangyu Biotechnology Development Co., Ltd
	2019-08-06	(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 278788-66-2	$8.80	1KG	97%-99%	100kg	Career Henan Chemical Co

(R)-1-BOC-3-(Hydroxymethyl)piperazine
278788-66-2
$98.00-990.00
98%
Zibo Hangyu Biotechnology Development Co., Ltd

(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
278788-66-2
$8.80
97%-99%
Career Henan Chemical Co

(R)-1-BOC-3-(Hydroxymethyl)piperazine Spectrum

(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(278788-66-2)¹HNMR (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(278788-66-2)FT-IR

278788-66-2((R)-1-BOC-3-(Hydroxymethyl)piperazine)Related Search:

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(3R)-3-(Hydroxymethyl)piperazine, N1-BOC protected 98% tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE (R)-1-Boc-3-hydroxymethyl-piperazine (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate H57159 (R)-4-Boc-2-hydroxymethyl-piperazine 1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)- (R)-1-Boc-3-(Hydroxymethyl)piperazine ,98% (R)-4-N-Boc-2-hydroxyMeth... (R)-1-Boc-3-(hyroxyMethyl)piperazine (3R)-3-(Hydroxymethyl)piperazine, N1-BOC protected tert-Butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate, (3R)-1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine (3R)-1-Boc-3-(hydroxyMethyl)-piperazine (3R)-3-(hydroxymethyL (3R)-3-(Hydroxymethyl)piperazine ert-butyl(3R)-3-(hydroxymethyl)piperazine-1-carboxylate PIPERAZINE-1-CARBOXYLIC (3R)-3-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester (R)-1-BOC-3-(Hydroxymethyl)piperazine tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate 278788-66-2 pharmacetical Piperaizine 1