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ChemicalBook >> CAS DataBase List >>(R)-1-BOC-3-(Hydroxymethyl)piperazine

(R)-1-BOC-3-(Hydroxymethyl)piperazine

(R)-1-BOC-3-(Hydroxymethyl)piperazine Structure
(R)-1-BOC-3-(Hydroxymethyl)piperazine structure
CAS No.
278788-66-2
Chemical Name:
(R)-1-BOC-3-(Hydroxymethyl)piperazine
Synonyms
tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate;tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate;(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate;H57159;(3R)-3-(hydroxymethyL;PIPERAZINE-1-CARBOXYLIC;(R)-4-N-Boc-2-hydroxyMeth...;(3R)-3-(Hydroxymethyl)piperazine;(R)-4-Boc-2-hydroxymethyl-piperazine
CBNumber:
CB9715509
Molecular Formula:
C10H20N2O3
Molecular Weight:
216.28
MDL Number:
MFCD05863888
MOL File:
278788-66-2.mol
MSDS File:
SDS
Last updated:2026-06-04 16:00:12
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(R)-1-BOC-3-(Hydroxymethyl)piperazine Properties

Melting point 68-70°C
Boiling point 322.9±22.0 °C(Predicted)
Density 1.085±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 14.97±0.10(Predicted)
color White to Off-White
optical activity Consistent with structure
InChI InChI=1S/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1
InChIKey NSILYQWHARROMG-MRVPVSSYSA-N
SMILES N1(C(OC(C)(C)C)=O)CCN[C@@H](CO)C1
CAS DataBase Reference 278788-66-2(CAS DataBase Reference)
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H315-H319
Precautionary statements  P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405
Hazard Codes  Xi
Risk Statements  41-52
Safety Statements  26-39
RIDADR  UN3259
HazardClass  8
HS Code  2933599590
Storage Class 11 - Combustible Solids
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

(R)-1-BOC-3-(Hydroxymethyl)piperazine price More Price(62)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SYX00408 (R)-1-BOC-3-(Hydroxymethyl)piperazine 278788-66-2 1g $506 2026-04-30 Buy
TRC TRC-B662275-1G (R)-1-Boc-3-hydroxymethylpiperazine 278788-66-2 1g $80 2026-06-03 Buy
AstaTech 58754 (R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE 97% 278788-66-2 1G $68 2026-04-30 Buy
AstaTech 58754 (R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE 97% 278788-66-2 5G $205 2026-04-30 Buy
AstaTech 58754 (R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE 97% 278788-66-2 25G $680 2026-04-30 Buy
Product number Packaging Price Buy
SYX00408 1g $506 Buy
TRC-B662275-1G 1g $80 Buy
58754 1G $68 Buy
58754 5G $205 Buy
58754 25G $680 Buy

(R)-1-BOC-3-(Hydroxymethyl)piperazine Chemical Properties, Uses, Production

Uses

(R)-1-Boc-3-hydroxymethylpiperazine is a used as a building block for the preparation of PI3K inhibitors for rheumatoid arthritis treatment,benzoxaborole derivatives as antimalarial agents and anti-tuberculosis agents.

Synthesis

1,4-bis-Boc-2-hydroxymethylpiperazine (13.9 kg) and 95% ethanol (30 kg) were added to the reactor, followed by the addition of an aqueous solution (water 21 kg) of configured sodium hydroxide (3.5 kg). The reaction mixture was then heated to reflux. Once the reaction was completed, ethanol was concentrated under reduced pressure. Subsequently, 30 kg of dichloromethane was added and the mixture was separated into liquid and aqueous phases. The aqueous phase was extracted three times with 3 × 20 kg of dichloromethane, and the organic phases were combined. The resulting solution was washed once with 40 kg of a 15% aqueous sodium chloride solution and dried with anhydrous sodium sulfate. Further purification was carried out to obtain (R)-1-BOC-3-(Hydroxymethyl)piperazine.
(R)-1-BOC-3-(Hydroxymethyl)piperazine

References

[1] Patent: EP1140904, 2005, B1. Location in patent: Page/Page column 35

(R)-1-BOC-3-(Hydroxymethyl)piperazine synthesis

1159598-21-6
278788-66-2
Synthesis of (R)-1-BOC-3-(Hydroxymethyl)piperazine from (R)-1,4-(Di-Boc)-2-(hydroxymethyl)piperazine

(R)-1-BOC-3-(Hydroxymethyl)piperazine Preparation Products And Raw materials

Raw materials

3H-Oxazolo[3,4-a]pyrazine-7(1H)-carboxylic acid, tetrahydro-1,3-dioxo-, 1,1-dimethylethyl ester, (8aR)- (R)-1,4-(Di-Boc)-2-(hydroxymethyl)piperazine Ethanol Sodium borohydride

Preparation Products

(R)-1-BOC-3-(Hydroxymethyl)piperazine Suppliers

Global Suppliers ( 257)
Supplier Tel Email Country ProdList Advantage
Chongqing Zhicheng Pharmaceutical Technology Co., Ltd. 13957683608 sales@zyscin.com China 62 58
Chengdu Firster Pharmaceutical Co., Ltd. 028-87078428 028-87074958 chengzhenyong@cdfirster.com China 2580 60
Sichuan Lancent Medical Devices Co., Ltd. 18111675298 stochem@aliyun.com China 215 58
Chengdu Aminotp Pharmaceutical Technology Co.,Ltd. 028-85755578 18140172005 sales@aminotp.com China 296 58
Chengdu Firster Pharmaceutical Co., Ltd. 19138996873 670603485@qq.com China 196 58
Chongqing Longsheng Pharmaceutical Co., Ltd 17791355738 sales@cqlonghoo.com China 105 58
Jiaxing Deyi Chemical Co., Ltd. 86-0573-85866609 18367600069 945717149@qq.com China 9506 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Supplier Advantage
Chongqing Zhicheng Pharmaceutical Technology Co., Ltd. 58
Chengdu Firster Pharmaceutical Co., Ltd. 60
Sichuan Lancent Medical Devices Co., Ltd. 58
Chengdu Aminotp Pharmaceutical Technology Co.,Ltd. 58
Chengdu Firster Pharmaceutical Co., Ltd. 58
Chongqing Longsheng Pharmaceutical Co., Ltd 58
Jiaxing Deyi Chemical Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
Wuhan Chemwish Technology Co., Ltd 56

View Latest Price from (R)-1-BOC-3-(Hydroxymethyl)piperazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-1-BOC-3-(Hydroxymethyl)piperazine pictures 2026-08-25 (R)-1-BOC-3-(Hydroxymethyl)piperazine
278788-66-2
 $98.00-990.00 5g 98% 50 Zibo Hangyu Biotechnology Development Co., Ltd
(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER pictures 2019-08-06 (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
278788-66-2
 $8.80 1KG 97%-99% 100kg Career Henan Chemical Co

(R)-1-BOC-3-(Hydroxymethyl)piperazine Spectrum

(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(278788-66-2)1HNMR(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(278788-66-2)FT-IR

278788-66-2 ((R)-1-BOC-3-(Hydroxymethyl)piperazine) Related Search:

(S)-1-Boc-3-hydroxymethyl-piperazine exo-3-Boc-3-azabicyclo[3.1.0]hexane-6-methanol (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester (R)-N-Boc-piperazine-2-carboxylic acid methyl ester tert-butyl (3S)-3-(hydroxymethyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate
3-N-Boc-Cis-Tetrahydrofuran-3,4-Diamine rel-(3r,4r)-3-(boc-amino)-5-fluoropiperidine (2S,4R)-4-hydroxy-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester tert-butyl ((3R,4R)-4-hydroxytetrahydro-2H-pyran-3-yl)carbamate tert-butyl (3R,4S)-3-amino-4-methylpyrrolidine-1-carboxylate
tert-butyl (3R)-3-aMino-4-(hydroxyMethyl)pyrrolidine-1-carboxyla (R)-tert-butyl 4-(1-aminoethyl)piperidine-1-carboxylate 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(R)-(9CI) (R)-3-Aminomethyl-1-N-Boc-pyrrolidine (R)-1-Boc-3-(Cyanomethyl)Piperidine
(6R,7S)-2-Boc-2-aza-bicyclo[2.2.1]hept-5-en-3-one N-Boc-(3S,4S)-3,4-pyrrolidinediol tert-butyl (2R,3S)-2-(3-aminopropyl)-3-((tert-butyldimethylsilyl)oxy)piperidine-1-carboxylate

1of4

(3R)-3-(Hydroxymethyl)piperazine, N1-BOC protected 98% tert-Butyl (3R)-3-(hydroxymethyl)-1-piperazinecarboxylate (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE (R)-1-Boc-3-hydroxymethyl-piperazine (R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate H57159 (R)-4-Boc-2-hydroxymethyl-piperazine 1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)- (R)-1-Boc-3-(Hydroxymethyl)piperazine ,98% (R)-4-N-Boc-2-hydroxyMeth... (R)-1-Boc-3-(hyroxyMethyl)piperazine (3R)-3-(Hydroxymethyl)piperazine, N1-BOC protected tert-Butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate, (3R)-1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperazine (3R)-1-Boc-3-(hydroxyMethyl)-piperazine (3R)-3-(hydroxymethyL (3R)-3-(Hydroxymethyl)piperazine ert-butyl(3R)-3-(hydroxymethyl)piperazine-1-carboxylate PIPERAZINE-1-CARBOXYLIC (3R)-3-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester (R)-1-BOC-3-(Hydroxymethyl)piperazine tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate tert-butyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate 278788-66-2 pharmacetical Piperaizine 1