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5-Bromo-4-fluoro-2-methylaniline

5-Bromo-4-fluoro-2-methylaniline structure

CAS No.: 627871-16-3

Chemical Name:: 5-Bromo-4-fluoro-2-methylaniline

Synonyms: 5-Bromo-4-fL;2-Methyl-4-fluoro-5-bromoaniline;BenzenaMine,5-broMo-4-fluoro-2-Methyl-;5-BROMO-4-FLUORO-2-METHYLANILINE ISO 9001：2015 REACH;2-Amino-4-bromo-5-fluorotoluene, 5-Bromo-4-fluoro-o-toluidine;5-Bromo-4-fluoro-2-methylaniline【2-Amino-4-bromo-5-fluorotoluene】;2-AMino-4-broMo-5-fluorotoluene[5-BroMo-4-fluoro-2-Methylaniline]

CBNumber:: CB8972996

Molecular Formula:: C7H7BrFN

Molecular Weight:: 204.04

MDL Number:: MFCD05865218

MOL File:: 627871-16-3.mol

MSDS File:: SDS

Last updated:2026-09-12 18:55:54

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5-Bromo-4-fluoro-2-methylaniline Properties

Melting point	86-90 °C (lit.)
Boiling point	266.3±35.0 °C(Predicted)
Density	1.589±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	3.44±0.10(Predicted)
form	Solid
Appearance	Off-white to light brown Solid
InChI	InChI=1S/C7H7BrFN/c1-4-2-6(9)5(8)3-7(4)10/h2-3H,10H2,1H3
InChIKey	DNCLVDGUXUSPTL-UHFFFAOYSA-N
SMILES	C1(N)=CC(Br)=C(F)C=C1C
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319

Precautionary statements

P264-P270-P280-P301+P312-P302+P352-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

22-36/38

Safety Statements

26-36

WGK Germany

HS Code

2921420090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2

NFPA 704

	1
2		0

5-Bromo-4-fluoro-2-methylaniline price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	639036	5-Bromo-4-fluoro-2-methylaniline 97%	627871-16-3	5g	$110	2026-04-30	Buy
Apolloscientific	PC6623	5-Bromo-4-fluoro-2-methylaniline ≥95%	627871-16-3	5g	$21	2026-06-04	Buy
Apolloscientific	PC6623	5-Bromo-4-fluoro-2-methylaniline ≥95%	627871-16-3	25g	$36	2026-06-04	Buy
Activate Scientific	AS24821	5-Bromo-4-fluoro-2-methylaniline 97%	627871-16-3	1g	$23	2026-06-04	Buy
Activate Scientific	AS24821	5-Bromo-4-fluoro-2-methylaniline 97%	627871-16-3	5g	$40	2026-06-04	Buy

Product number	Packaging	Price	Buy
639036	5g	$110	Buy
PC6623	5g	$21	Buy
PC6623	25g	$36	Buy
AS24821	1g	$23	Buy
AS24821	5g	$40	Buy

5-Bromo-4-fluoro-2-methylaniline Chemical Properties, Uses, Production

Chemical Properties

light brown solid

Uses

5-Bromo-4-fluoro-2-methylaniline is used to prepare 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.

Synthesis

224185-19-7

627871-16-3

The general procedure for the synthesis of 5-bromo-4-fluoro-2-methylaniline from 2-nitro-4-bromo-5-fluorotoluene was as follows: a mixture of iron powder (17.8 g, 318 mmol) and ammonium chloride (5.10 g, 95.4 mmol) in water (100 mL) was heated to reflux for 30 minutes. Subsequently, 4-bromo-3-fluoro-6-nitrotoluene (18.6 g, 79.5 mmol) was slowly added to this hot mixture and the reaction mixture was continued to reflux for 48 hours. Upon completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (3 x 200 mL). The organic phases were combined, washed sequentially with water (3 × 300 mL) and brine (300 mL), dried over anhydrous sodium sulfate and concentrated. The residue was purified by fast column chromatography (silica gel as stationary phase and hexane solution of 20% ethyl acetate as eluent) to afford 11.7 g of 5-bromo-4-fluoro-2-methylaniline as a light yellow solid in 72% yield. The product was characterized by 1H NMR (CDCl3, 300 MHz): δ 6.82 (m, 2H), 3.49 (bs, 2H), 2.11 (s, 3H).

References

[1] Advanced Synthesis and Catalysis, 2012, vol. 354, # 2-3, p. 321 - 327
[2] Patent: WO2003/99824, 2003, A1. Location in patent: Page 32
[3] Patent: WO2003/99275, 2003, A1. Location in patent: Page 65
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 2, p. 457 - 460
[5] Journal of Medicinal Chemistry, 2004, vol. 47, # 26, p. 6603 - 6608

5-Bromo-4-fluoro-2-methylaniline synthesis

Synthesis of 5-Bromo-4-fluoro-2-methylaniline from 4-Bromo-3-fluorotoluene

5-Bromo-4-fluoro-2-methylaniline Preparation Products And Raw materials

Raw materials

4-Bromo-5-fluoro-2-nitrotoluene 4-Bromo-3-fluorotoluene Ammonium chloride Iron

Preparation Products

Acetamide, N-(5-bromo-4-fluoro-2-methylphenyl)-

5-Bromo-4-fluoro-2-methylaniline Suppliers

Global Suppliers ( 164)

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Daolan Biomedical Technology Co., Ltd.	13771737464	sales@dolanchem.com	China	2172	58
Aribo Pharmatech Co., Ltd.	19951442182	sales@aribopharm.com	China	1781	58
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Shanghai Harvest Chemical Industrial Co., Ltd.	15721252604 17321035817	sales@harvest-chem.com	China	2829	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Beijing Eternalchem Co,. Ltd.	010-59484199 18611897322;18611897322;	sales@eternalchem.com	China	1993	60
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66

Supplier	Advantage
Suzhou Daolan Biomedical Technology Co., Ltd.	58
Aribo Pharmatech Co., Ltd.	58
Alfa Aesar	84
Energy Chemical	61
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
Shanghai Harvest Chemical Industrial Co., Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Beijing Eternalchem Co,. Ltd.	60
China DongFan Chemical Co.,LTD	66

View Latest Price from 5-Bromo-4-fluoro-2-methylaniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	5-BROMO-4-FLUORO-2-METHYLANILINE 627871-16-3	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2021-07-13	5-BROMO-4-FLUORO-2-METHYLANILINE 627871-16-3	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	5-BROMO-4-FLUORO-2-METHYLANILINE 627871-16-3	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

5-BROMO-4-FLUORO-2-METHYLANILINE
627871-16-3
$1.10
99.00%
Dideu Industries Group Limited

5-BROMO-4-FLUORO-2-METHYLANILINE
627871-16-3
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

5-BROMO-4-FLUORO-2-METHYLANILINE
627871-16-3
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

5-Bromo-4-fluoro-2-methylaniline Spectrum

5-BROMO-4-FLUORO-2-METHYLANILINE(627871-16-3)¹HNMR

627871-16-3 (5-Bromo-4-fluoro-2-methylaniline) Related Search:

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4-Bromo-5-fluoro-2-nitrotoluene AKOS 91776

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BenzenaMine,5-broMo-4-fluoro-2-Methyl- 2-AMino-4-broMo-5-fluorotoluene[5-BroMo-4-fluoro-2-Methylaniline] 2-Amino-4-bromo-5-fluorotoluene, 5-Bromo-4-fluoro-o-toluidine 2-Methyl-4-fluoro-5-bromoaniline 5-Bromo-4-fL 5-BROMO-4-FLUORO-2-METHYLANILINE ISO 9001：2015 REACH 5-Bromo-4-fluoro-2-methylaniline【2-Amino-4-bromo-5-fluorotoluene】 627871-16-3 Aryl Fluorinated Building Blocks Building Blocks C7-C8 Chemical Synthesis Fluorinated Building Blocks Nitrogen Compounds Organic Building Blocks Organic Fluorinated Building Blocks Other Fluorinated Organic Building Blocks Amines C7 Nitrogen Compounds