CHROMECEPTIN
- CAS No.
- 331859-86-0
- Chemical Name:
- CHROMECEPTIN
- Synonyms
- 94G6;CHROMECEPTIN;Chromeceptin, 10 mM in DMSO;2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene;94G6, 2-Amino-3-cyano-7-dimethylamino-4-(3-trifluoromethylphenyl)-4H-chromene;2-Amino-7-(dimethylamino)-4-(3-(trifluoromethyl)phenyl)-4H-chromene-3-carbonitrile;4H-1-Benzopyran-3-carbonitrile, 2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-
- CBNumber:
- CB8973029
- Molecular Formula:
- C19H16F3N3O
- Molecular Weight:
- 359.35
- MDL Number:
- MFCD00815850
- MOL File:
- 331859-86-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 199-200 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Boiling point | 497.2±45.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | H2O: <2mg/mL |
| form | solid |
| pka | 4.23±0.70(Predicted) |
| color | yellow to brown |
| Water Solubility |
H2O: <2mg/mL DMSO: >20mg/mL |
| InChI | 1S/C19H16F3N3O/c1-25(2)13-6-7-14-16(9-13)26-18(24)15(10-23)17(14)11-4-3-5-12(8-11)19(20,21)22/h3-9,17H,24H2,1-2H3 |
| InChIKey | GVINXTXGDDSXFQ-UHFFFAOYSA-N |
| SMILES | CN(C)c1ccc2C(c3cccc(c3)C(F)(F)F)C(C#N)=C(N)Oc2c1 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
CHROMECEPTIN price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C0868 | Chromeceptin ≥98% (HPLC), solid | 331859-86-0 | 5mg | $214 | 2026-04-30 | Buy |
| Sigma-Aldrich | C0868 | Chromeceptin ≥98% (HPLC), solid | 331859-86-0 | 25mg | $801 | 2022-05-15 | Buy |
| ChemScene | CS-0086988 | Chromeceptin 99.80% | 331859-86-0 | 5mg | $97 | 2026-06-04 | Buy |
| ChemScene | CS-0086988 | Chromeceptin 99.80% | 331859-86-0 | 10mg | $152 | 2026-06-04 | Buy |
| ChemScene | CS-0086988 | Chromeceptin 99.80% | 331859-86-0 | 25mg | $314 | 2026-06-04 | Buy |
CHROMECEPTIN Chemical Properties,Uses,Production
Uses
Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR[1].
Biochem/physiol Actions
Chromeceptin inhibits Insulin-like growth factor 2 (IGF2) signaling by a process that begins with chromeceptin binding to multifunctional protein 2 (MFP-2). This interaction stimulates the expression of IGF binding protein 1 (IGFBP-1) and suppressor of cytokine signaling-3 (SOCS-3), both of which activate signal transducers and activators of transcription 6 (STAT6) to attenuate IGF signals.
References
[1] Seol HS, et al. Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma. Sci Rep. 2020 Dec 8;10(1):21412. DOI:10.1038/s41598-020-77960-9
CHROMECEPTIN Preparation Products And Raw materials
Raw materials
Preparation Products
CHROMECEPTIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19684 | 58 |
| Wuxi Donghe Pharmaceutical Technology Co., Ltd. | 63313187 15358055255 | 63313187@qq.com | China | 1982 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
View Lastest Price from CHROMECEPTIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Chromeceptin
331859-86-0
|
$30.00-100.00 | 99.85% | 10g | TargetMol Chemicals Inc. |
-
- Chromeceptin
331859-86-0
- $30.00-100.00
- 99.85%
- TargetMol Chemicals Inc.
