K-Ras ligand-Linker Conjugate 1

K-Ras ligand-Linker Conjugate 1 structure

CAS No.: 2749492-84-8

Chemical Name:: K-Ras ligand-Linker Conjugate 1

Synonyms: K-Ras ligand-Linker Conjugate 1;1-Piperazinecarboxylic acid, 2-(cyanomethyl)-4-[2-[[(2R,4S)-4-[2-[2-[2-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]ethoxy]ethoxy]ethoxy]-1-methyl-2-pyrrolidinyl]methoxy]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-, phenylmethyl ester, (2R)-rel-

CBNumber:: CB89733741

Molecular Formula:: C43H54N8O9

Molecular Weight:: 826.94

MDL Number:

MOL File:: 2749492-84-8.mol

Last updated:2025-05-19 13:47:27

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K-Ras ligand-Linker Conjugate 1 Properties

Boiling point	952.898±75.00 °C(Press: 760.00 Torr)(predicted)
Density	1.362±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	7.980±0.60(predicted)

K-Ras ligand-Linker Conjugate 1 Chemical Properties, Uses, Production

Uses

K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].

References

[1] CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

K-Ras ligand-Linker Conjugate 1 Preparation Products And Raw materials

Raw materials

Preparation Products

K-Ras ligand-Linker Conjugate 1 Suppliers

Global Suppliers ( 2)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
Henan Mengtai Pharmaceutical Technology Co., Ltd	17634413542	1959525201@qq.com	China	9011	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Henan Mengtai Pharmaceutical Technology Co., Ltd	58

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K-Ras ligand-Linker Conjugate 1 1-Piperazinecarboxylic acid, 2-(cyanomethyl)-4-[2-[[(2R,4S)-4-[2-[2-[2-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]ethoxy]ethoxy]ethoxy]-1-methyl-2-pyrrolidinyl]methoxy]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-, phenylmethyl ester, (2R)-rel- 2749492-84-8