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| | K-Ras ligand-Linker Conjugate 1 Basic information |
| Product Name: | K-Ras ligand-Linker Conjugate 1 | | Synonyms: | K-Ras ligand-Linker Conjugate 1;1-Piperazinecarboxylic acid, 2-(cyanomethyl)-4-[2-[[(2R,4S)-4-[2-[2-[2-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy]ethoxy]ethoxy]ethoxy]-1-methyl-2-pyrrolidinyl]methoxy]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-, phenylmethyl ester, (2R)-rel- | | CAS: | 2749492-84-8 | | MF: | C43H54N8O9 | | MW: | 826.94 | | EINECS: | | | Product Categories: | | | Mol File: | 2749492-84-8.mol |  |
| | K-Ras ligand-Linker Conjugate 1 Chemical Properties |
| Boiling point | 952.898±75.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.362±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 7.980±0.60(predicted) |
| | K-Ras ligand-Linker Conjugate 1 Usage And Synthesis |
| Uses | K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1]. | | References | [1] CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2. |
| | K-Ras ligand-Linker Conjugate 1 Preparation Products And Raw materials |
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