Benzamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-4-[[2-(4-morpholinyl)-2-oxoethyl]amino]-
![Benzamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-4-[[2-(4-morpholinyl)-2-oxoethyl]amino]- Structure](CAS/20210305/GIF/2073059-82-0.gif)
- CAS No.
- 2073059-82-0
- Chemical Name:
- Benzamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-4-[[2-(4-morpholinyl)-2-oxoethyl]amino]-
- Synonyms
- Benzamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-4-[[2-(4-morpholinyl)-2-oxoethyl]amino]-
- CBNumber:
- CB89834550
- Molecular Formula:
- C23H24N4O4S
- Molecular Weight:
- 452.53
- MDL Number:
- MOL File:
- 2073059-82-0.mol
- MSDS File:
- SDS
| Density | 1.352±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 4°C, protect from light |
| solubility | DMSO : 100 mg/mL (220.98 mM; ultrasonic and warming and heat to 60°C) |
| form | Solid |
| pka | 7.55±0.50(Predicted) |
| color | White to off-white |
Benzamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-4-[[2-(4-morpholinyl)-2-oxoethyl]amino]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0088282 | SBI-993 98.79% | 2073059-82-0 | 5mg | $271 | 2026-06-04 | Buy |
| ChemScene | CS-0088282 | SBI-993 98.79% | 2073059-82-0 | 10mg | $455 | 2026-06-04 | Buy |
| ChemScene | CS-0088282 | SBI-993 98.79% | 2073059-82-0 | 25mg | $997 | 2026-06-04 | Buy |
| ChemScene | CS-0088282 | SBI-993 98.79% | 2073059-82-0 | 50mg | $1625 | 2026-06-04 | Buy |
| ChemScene | CS-0088282 | SBI-993 98.79% | 2073059-82-0 | 100mg | $2112 | 2026-06-04 | Buy |
Benzamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-4-[[2-(4-morpholinyl)-2-oxoethyl]amino]- Chemical Properties, Uses, Production
Uses
SBI-993 is a SBI-477 analog with improved potency and suitable pharmacokinetic properties for in vivo bioavailability. SBI-993 stimulates insulin signaling by deactivating the transcription factor MondoA[1].
in vivo
SBI-993 (50 mg/kg; s.c.; daily; for 7 days) treatment reduces the expression of triacylglyceride synthesis and lipogenic genes in both muscle and liver. SBI-993 also reduces Txnip and Arrdc4 expression. And ccupation of both ChREBP and MondoA on the Txnip and pyruvate kinase (Pklr) gene promoters is reduced in liver by SBI-993[1].
SBI-993 improves insulin signaling in both muscle and liver following an acute insulin challenge[1].
| Animal Model: | Mice are fed a 60% high-fat diet (HFD)[1] |
| Dosage: | 50 mg/kg |
| Administration: | s.c.; daily; for 7 days |
| Result: | Reduced the expression of triacylglyceride synthesis and lipogenic genes in both muscle and liver. |
References
[1] Byungyong Ahn, et al. MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest. 2016 Sep 1;126(9):3567-79. DOI:10.1172/JCI87382
Benzamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-4-[[2-(4-morpholinyl)-2-oxoethyl]amino]- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-4-[[2-(4-morpholinyl)-2-oxoethyl]amino]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 9995 | 58 |
| Zhejiang Huida Biotech Co., Ltd. | 0571-89903022 18679456698 | zilong@hizyme.com | China | 7853 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 58 |
| Zhejiang Huida Biotech Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
