ChemicalBook >> CAS DataBase List >>1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]-

1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]-

1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]- structure

CAS No.: 2401892-75-7

Chemical Name:: 1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]-

Synonyms: Lotiglipron;2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl;2-[[4-[(2S)-2-(5-Chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]-1H-benzimidazole-6-carboxylic acid;1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]-;2-((4-((S)-2-(5-chloropyridin-2-yl)-2-methylbenzo(d][1,3]dioxol-4-yl)piperidin-1 -yl)methyl)-1 -(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid

CBNumber:: CB910476205

Molecular Formula:: C31H31ClN4O5

Molecular Weight:: 575.05

MDL Number:

MOL File:: 2401892-75-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:40:06

Request For Quotation

1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]- Properties

Boiling point	752.9±60.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
pka	7.82±0.10(Predicted)
form	Solid
color	White to off-white
FDA UNII	YI10W1K93A

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0865718	Lotiglipron 98.96%	2401892-75-7	1mg	$95	2026-06-04	Buy
ChemScene	CS-0865718	Lotiglipron 98.96%	2401892-75-7	5mg	$191	2026-06-04	Buy
ChemScene	CS-0865718	Lotiglipron 98.96%	2401892-75-7	10mg	$287	2026-06-04	Buy
ChemScene	CS-0865718	Lotiglipron 98.96%	2401892-75-7	25mg	$574	2026-06-04	Buy
ChemScene	CS-0865718	Lotiglipron 98.96%	2401892-75-7	50mg	$747	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0865718	1mg	$95	Buy
CS-0865718	5mg	$191	Buy
CS-0865718	10mg	$287	Buy
CS-0865718	25mg	$574	Buy
CS-0865718	50mg	$747	Buy

1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]- Chemical Properties,Uses,Production

Uses

Lotiglipron (PF-07081532) is an orally active GLP-1R agonist. Lotiglipron reduces glucose and body weight, and can be used for research of Type 2 diabetes mellitus (T2DM)[1].

References

[1] Buckeridge C, et al. Once-daily oral small molecule GLP-1R agonist PF-07081532 reduces glucose and body weight within 4-6 weeks in adults with type 2 diabetes and non-diabetic adults with obesity. Hybrid 58th EASD Annual Meeting; Sept 19–23, 2022 (abstr 114).
[2] Sloop KW, et al., The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron. Sci Transl Med. 2024 Dec 18;16(778):eadp5765. DOI:10.1126/scitranslmed.adp5765

1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]- Suppliers

Global( 28)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4861	55
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
ChengDu TongChuangYuan Pharmaceutical Co.Ltd	028-83379370 13880556291	tcy@tcypharm.com	China	8696	58
Kaixin Chemical (Hong Kong) Limited	010-88886666-01 13112345678	loyson@qq.com	China	589	55
Anhui Enbang Biological Technology Co., Ltd.	0551-68936860-8515 15357955825	15357955825@163.com	China	82	55
Shandong utilizing biological technology co., LTD	18669728830 15966937598	3407650895@qq.com	China	5157	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8491	58
Changzhou Chenhong Biotechnology Co., Ltd.	+86-0519-85788828 +86-13775037613	sales@chemrenpharm.com	China	4058	58
Chunchuang (Wuhan) Technology Co., Ltd	15727060112	yutianchun2007@126.com	China	9867	58

Supplier	Advantage
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Lollane Biological Technology Co.,Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
ChengDu TongChuangYuan Pharmaceutical Co.Ltd	58
Kaixin Chemical (Hong Kong) Limited	55
Anhui Enbang Biological Technology Co., Ltd.	55
Shandong utilizing biological technology co., LTD	58
Jinan Carbotang Biotech Co.,Ltd.	58
Changzhou Chenhong Biotechnology Co., Ltd.	58
Chunchuang (Wuhan) Technology Co., Ltd	58

1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]- Spectrum

1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]-(2401892-75-7)¹HNMR

2401892-75-7(1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]-)Related Search:

1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(4-chloro-2-fluorophenyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]- 1H-Benzimidazole-6-carboxylic acid, 2-[[4-[2-(4-chloro-2-fluorophenyl)-7-fluoro-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]- 1H-Benzimidazole-6-carboxylic acid, 2-[[4-[2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]- 1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2R)-2-(4-chloro-2-fluorophenyl)-7-fluoro-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]- 1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]-

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1H-Benzimidazole-6-carboxylic acid, 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]- 2-((4-((S)-2-(5-chloropyridin-2-yl)-2-methylbenzo(d][1,3]dioxol-4-yl)piperidin-1 -yl)methyl)-1 -(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid 2-[[4-[(2S)-2-(5-chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl Lotiglipron 2-[[4-[(2S)-2-(5-Chloro-2-pyridinyl)-2-methyl-1,3-benzodioxol-4-yl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]-1H-benzimidazole-6-carboxylic acid 2401892-75-7