TAPSO
- CAS No.
- 68399-81-5
- Chemical Name:
- TAPSO
- Synonyms
- APSO;TAPSO;TAPSO Buffer;TAPSO FREE ACID;TAPSO ULTRAPURE;TAPSO,BIOLOGICALBUFFER;TAPSO, for biochemistry;Tapso≥ 99.9% (titration);TAPSO ISO 9001：2015 REACH;TAPSO FREE ACID SIGMAULTRA
- CBNumber:
- CB9105092
- Molecular Formula:
- C7H17NO7S
- Molecular Weight:
- 259.28
- MDL Number:
- MFCD00038352
- MOL File:
- 68399-81-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 224-229 °C (dec.) |
|---|---|
| Density | 1.07607 g/cm3(Temp: 25.00 °C) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | H2O: 1 M at 20 °C, clear, colorless |
| form | Powder |
| color | Off-white to yellow |
| pka | 7.6(at 25℃) |
| PH | 7.0-8.2 |
| PH Range | 7.0 - 8.2 |
| Water Solubility | soluble |
| Merck | 13,9148 |
| BRN | 2113949 |
| Major Application | diagnostic assay manufacturing |
| InChI | InChI=1S/C7H17NO7S/c9-3-7(4-10,5-11)8-1-6(12)2-16(13,14)15/h6,8-12H,1-5H2,(H,13,14,15) |
| InChIKey | RZQXOGQSPBYUKH-UHFFFAOYSA-N |
| SMILES | C(S(O)(=O)=O)C(O)CNC(CO)(CO)CO |
| CAS DataBase Reference | 68399-81-5(CAS DataBase Reference) |
| FDA UNII | 45Q4J0071U |
| EPA Substance Registry System | 1-Propanesulfonic acid, 2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]- (68399-81-5) |
| UNSPSC Code | 12161700 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29221990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
TAPSO price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T9269 | TAPSO ≥99% (titration) | 68399-81-5 | 100g | $98.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | T9269 | TAPSO ≥99% (titration) | 68399-81-5 | 25g | $24.3 | 2023-06-20 | Buy |
| TCI Chemical | T1364 | 3-[N-Tris(hydroxymethyl)methylamino]-2-hydroxypropanesulfonic Acid [Good's buffer component for biological research] >99.0%(T) | 68399-81-5 | 25g | $29 | 2026-04-30 | Buy |
| Usbiological | T1010 | TAPSO Free Acid ≥99% | 68399-81-5 | 100g | $99 | 2026-06-04 | Buy |
| Usbiological | T1010 | TAPSO Free Acid ≥99% | 68399-81-5 | 250g | $213 | 2026-06-04 | Buy |
TAPSO Chemical Properties, Uses, Production
Chemical Properties
white powder
Uses
TAPSO is a zwitterionic biological buffer often used as a buffering agent in biological and biochemical research. It has a pKa value of 7.635 (I=0, 25°C) and can be used to make buffer solutions in the pH range 7.0-8.2. As an Good'buffer, TAPSO contains Tris groups and exhibits quite reactive activity with zwitterionic glycine peptides[1]. TAPSO can serve as good stabilizers for the globular protein BSA, in the aqueous solutions[2].The solubilities of TAPSO increase with increasing concentration of the salts (salting-in effect)[3].
Synthesis
N-Tris(hydroxymethyl)methane-2-hydroxypropanesulfonic acid was prepared as follows: a mixture of 242.28 g (2 mol) of tris(hydroxymethyl)aminomethane, 500 ml of water and 196.5 g (1 mol) of sodium 3-chloro-2-hydroxypropanesulphonate was charged into a 1-liter 2-necked flask fitted with a stirrer and condenser. The mixture was stirred vigorously at reflux for 3 hours. After cooling to 25C, the solution was allowed to pass through a Dowex 50, hydrogen form cation exchange resin column to remove the sodium cation and form a free acid. The eluate from the column was evaporated under vacuum to a thick oil. After dilution with alcohol, the product was crystallized from the solution, filtered and washed with alcohol and dried. 160 g of the white product N-tris(hydroxymethyl)methionine-2-hydroxypropanesulfonic acid was obtained.
References
[1] Gupta B, et al. Stability Constants for the Equilibrium Models of Iron(III) with Several Biological Buffers in Aqueous Solutions. Journal of Solution Chemistry, 2013; 42: 2296–2309.
[2] Gupta ;B, et al. Interactions of bovine serum albumin with biological buffers, TES, TAPS, and TAPSO in aqueous solutions. Process Biochemistry, 2013; 48: 1686-1696.
[3] Taha M, et al. New Insights into Buffer-Ionic Salt Interactions: Solubilities, Transfer Gibbs Energies, and Transfer Molar Volumes of TAPS and TAPSO from Water to Aqueous Electrolyte Solutions. Journal of Solution Chemistry, 2010; 39:1665–1680.
TAPSO Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hu' nan Yunbang Pharmaceutical Co., Ltd. | 0731-88532326 13319508186 | yunbang@yunbangapi.com | China | 8516 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 45000 | 61 |
| Nanjing Search Biotech Co., Ltd | +86-025-81682922 +86-13515111588 | sales@searchbio.com.cn | China | 137 | 68 |
| Adamas Reagent, Ltd. | 4006009262 13023226327 | hmj@titansci.com | China | 14098 | 59 |
| Beijing Isomersyn Technology CO;LTD | 010-82954736 13391601435 | sales@isomersyn.com | China | 3294 | 57 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
View Latest Price from TAPSO manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-21 | TAPSO
68399-81-5
|
1KG | 99% | 3500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-22 | TAPSO
68399-81-5
|
1kg | 99% | 20MT | Watson Biotechnology Co.,Ltd | ||
![2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propanesulphonic acid (TAPSO) pictures](/ProductImageEN2/2026-03/Small/89caa340-4368-4ca5-9455-774444588428.gif) |
2026-04-21 | 2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propanesulphonic acid (TAPSO)
68399-81-5
|
25kg | ≥99 % | 300tons/year | Wuhan Hugarise New Material Co.,Ltd |
-
- TAPSO
68399-81-5
- $0.00
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- TAPSO
68399-81-5
- 99%
- Watson Biotechnology Co.,Ltd
-
- 2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propanesulphonic acid (TAPSO)
68399-81-5
- $0.00
- ≥99 %
- Wuhan Hugarise New Material Co.,Ltd
