Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI)
- CAS No.
- 185619-66-3
- Chemical Name:
- Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI)
- Synonyms
- N-Boc-3-ethynylaniline;tert-butyl 3-ethynylphenylcarbamate;tert-butyl N-(3-ethynylphenyl)carbamate;tert-Butyl (3-ethynylphenyl)carbamate - [B56910];Carbamic acid, N-(3-ethynylphenyl)-, 1,1-dimethylethyl ester;Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI)
- CBNumber:
- CB91054814
- Molecular Formula:
- C13H15NO2
- Molecular Weight:
- 217.26
- MDL Number:
- MFCD14585306
- MOL File:
- 185619-66-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2924297099 |
Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI) price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR322882 | tert-Butyl 3-ethynylphenylcarbamate 98% | 185619-66-3 | 1g | $90 | 2026-06-04 | Buy |
| Apolloscientific | OR322882 | tert-Butyl 3-ethynylphenylcarbamate 98% | 185619-66-3 | 5g | $368 | 2026-06-04 | Buy |
| Activate Scientific | AS47149 | N-Boc-3-ethynylaniline 97% | 185619-66-3 | 1g | $73 | 2026-06-04 | Buy |
| Apolloscientific | OR322882 | tert-Butyl 3-ethynylphenylcarbamate 98% | 185619-66-3 | 25g | $1503 | 2026-06-04 | Buy |
| Activate Scientific | AS47149 | N-Boc-3-ethynylaniline 97% | 185619-66-3 | 5g | $362 | 2026-06-04 | Buy |
Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI) Chemical Properties, Uses, Production
Synthesis
24424-99-5
54060-30-9
185619-66-3
Step a) Synthesis of tert-butyl (3-ethynylphenyl)carbamate: 3-ethynylaniline (25.0 g, 213 mmol) and di-tert-butyl dicarbonate (93.1 g, 427 mmol) were dissolved in THF (427 mL) and the reaction was heated at 70 °C overnight. After the reaction was completed, it was cooled to room temperature, 3-dimethylamino-1-propylamine (32.1 g, 320 mmol) was added and stirred at room temperature for 1 hour. The reaction mixture was concentrated, extracted with ether and washed sequentially with 1N HCl, saturated saline, saturated sodium bicarbonate solution and saturated saline. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product tert-butyl (3-alkynylphenyl)carbamate (45.0 g, 97% yield). The structure of the product was confirmed by NMR and mass spectrometry.
References
[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 20, p. 4232 - 4235
[2] Patent: US2009/48320, 2009, A1. Location in patent: Page/Page column 39-40
[3] Patent: WO2005/60970, 2005, A1. Location in patent: Page/Page column 148
[4] Patent: WO2017/210471, 2017, A1. Location in patent: Paragraph 001146; 001147
[5] Patent: WO2008/61236, 2008, A2. Location in patent: Page/Page column 71
Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2304 | 55 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4534 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 400-867-5858;400-867-5858 | info@amateksci.com | China | 28760 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| 3A Chemicals | 400-668-9898 | service@3achem.com | China | 20535 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Aishilun biotechnology (Shanghai) co., LTD | 021-50676523 18019098996 | info@acelybio.com | China | 3950 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +86-18530059196 | sale04@alfachem.cn | China | 9745 | 58 |
View Latest Price from Carbamic acid, (3-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-25 | TERT-BUTYL (3-ETHYNYLPHENYL)CARBAMATE
185619-66-3
|
$100.00 | 1KG | 98% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | tert-butyl N-(3-ethynylphenyl)carbamate
185619-66-3
|
$100.00 | 1Kg/Bag | 98% | 10KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | TERT-BUTYL (3-ETHYNYLPHENYL)CARBAMATE
185619-66-3
|
$100.00 | 1KG | 99% | 10kg | Hong Kong Tiansheng New Material Trading Co., Ltd |
-
- TERT-BUTYL (3-ETHYNYLPHENYL)CARBAMATE
185619-66-3
- $100.00
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- tert-butyl N-(3-ethynylphenyl)carbamate
185619-66-3
- $100.00
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- TERT-BUTYL (3-ETHYNYLPHENYL)CARBAMATE
185619-66-3
- $100.00
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
